DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nha2 and Slc9b1

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001167444.1	Gene:	Slc9b1 / 365946	RGDID:	1305087	Length:	519	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	139/444 - (31%)
Similarity:	223/444 - (50%)	Gaps:	32/444 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 LWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVH------LPDMLGMLFFGVLYANLGL 316
            ||.:.|.|:.:...|...:..:..:|..|.:.|.::..:.      ||.:||||..|....|:.:
  Rat    82 LWILLWALIGQEVLPGGNLFGLVVIFYSAFLGGKIIEVIRIPVVPPLPPLLGMLLAGFTIRNVPI 146

  Fly   317 ANFEGYQ------KFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGL 375
            .    |:      .:...||..||..|::.||||||..|.|.|..:.|||:..|.::|..:.|..
  Rat   147 L----YKFVHIPTSWSSALRNTALTIILIRAGLGLDPQALKHLKGVCLRLSFGPCLLEACSAALF 207

  Fly   376 ANLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFG 440
            ::..::.||.||..||.|:.||||.|||..||.|:|:..|:..||.||:.|.::.:|:|||..|.
  Rat   208 SHFIMNFPWQWGFLLGFVLGAVSPAVVVPNMLLLQENGYGVEKGIPTLLVAASSMDDIVAITGFN 272

  Fly   441 VIISVIFSTTSLTQQVLQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVM 505
            ..:|::||:.|:...:|.....:.||::.|.:.|..:||.|||:.......|..|.:.....||:
  Rat   273 TFLSIVFSSGSVISNILSSLRDVLIGVLVGVVMGIFVQYFPSRDQERLTQRRAFLVLSMCVSAVL 337

  Fly   506 GSRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFALI 570
            |.:.||...:|.|..:..:|:|...|             |::...|.|.:...|...:|:.|.|:
  Rat   338 GCQHIGLHGSGGLVTLVLSFMAAKRW-------------AEEKVGVQKLVANTWNIFQPLLFGLV 389

  Fly   571 GKEINFNVLQGHVIGYGALLVLVGSLFRLAFAYLSTYGGNLSRKERAYITISGFPKATVQAALGP 635
            |.|::...|:...||.....:.:..|.|:...::.....|....|:.:|.:|..|||||||.|||
  Rat   390 GTEVSVESLESKTIGMCIATLCLALLVRILATFVLMSFANFRFMEKVFIALSWIPKATVQAVLGP 454

  Fly   636 VALDMARAASVASPEQLALAGNLLIISVLAIIFTAPLGAILMLRLAPYWLKHGD 689
            :||:.||   |.:|.....:.|::.::.|||:.|||.||:::..|.|..|.|.:
  Rat   455 LALETAR---VMAPHLEGYSRNVMTVAFLAILITAPNGALIIGILGPKVLDHSE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	132/418 (32%)
Slc9b1	NP_001167444.1	Na_H_Exchanger	145..496	CDD:294713	119/370 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D406317at33208
OrthoFinder	1	1.000	-	-		FOG0001578
OrthoInspector	1	1.000	-	-		mtm8970
orthoMCL	1	0.900	-	-		OOG6_103025
Panther	1	1.100	-	-	O	PTHR31102
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710