Protein Alignment Nha2 and Nhe1

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_608491.3
• Gene: Nhe1 / 33167
• FlyBaseID: FBgn0026787
• Length: 649
• Species: Drosophila melanogaster
• Alignment Length: 546
• Identity: 115/546 - (21%)
• Similarity: 196/546 - (35%)
• Gaps: 158/546 - (28%)

  Fly   160 PEDEAGADATQNAATIILTPTSLNLTNTTTQNVAANN-----------AGNSSTTTSTNTNYGPG 213
            ||..:|.:..|:..:...|.|..:.:..|..:|..|:           :||:|||...|.:   .
  Fly    20 PESISGQEVPQSKTSSNTTTTDNSSSIHTVSDVFVNSPLGNVTPSISASGNASTTKRGNAS---T 81

  Fly   214 SVSGYPTPNATPGDEYKGPKWWLYIRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQPPTVIMR 278
            .|:..|                 .|.||.|......:|...|:....|..:||
  Fly    82 LVTDPP-----------------LIDSHAVEQEHNSSLSLFFVICVIMLGILL------------ 117

  Fly   279 IAFLFVGAQISGILVT-FVHLPDMLGMLFFGVLYANLGLANFEG----YQKFELFLREMALINIM 338
                     |..:|.| |.:||:.:.::|.|. :..|.|....|    :::.|:| ..|....::
  Fly   118 ---------IHSMLQTGFQYLPESIVVVFLGA-FIGLSLNVMSGQNGSWKREEVF-SPMGFFLVL 171

  Fly   339 L-----LAGLGL-DGDAFKR----LWFMILRLTLLPTIVEVAA-IAGLANLTLSMPWLWGIALGL 392
            |     .:|..| .|:.|:.    |.|.|...|:...::.... :.||..:...:.:....|.|.
  Fly   172 LPPIIFESGYNLHKGNFFQNIGSILVFAIFGTTISALVIGAGIYLLGLGEVAFRLSFSESFAFGS 236

  Fly   393 VITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQV- 456
            :|:||.|...|.:...|..|.:     ::.|::..:..||.::|.:          |.|:||..
  Fly   237 LISAVDPVATVAIFHALDVDPI-----LNMLVFGESILNDAISIVL----------TASITQSAN 286

  Fly   457 --LQGPIG-----------------IGIGLVFGYLYGSMLQYLPSRN-----------ATYANGL 491
              .:...|                 .|||::|..:...:|:::..|.           .|||
  Fly   287 VNAEASTGEAMFSALKTFCAMFFASAGIGVIFALISALLLKHIDLRKHPSLEFAMMLMFTYA--- 348

  Fly   492 RFVLT---ILGGTIAVM--GSRVIGYTSAGALGCV----------TTAFIARIGWRREETRLTPQ 541
            .:||.   .|.|.:|::  |..:..||... |..|          |.||||       ||.:...
  Fly   349 PYVLAEGIHLSGIMAILFCGIVMSHYTHFN-LSTVTQITMQQTMRTLAFIA-------ETCVFAY 405

  Fly   542 QLQAQQIASVPKRLDL---MWKFLKPVSFALIGKEINF-------NVLQGHVIGYGALLVLVGSL 596
            ...|  |.|...:::|   :|    .:...|||:..|.       |..:.|.|......::..|.
  Fly   406 LGLA--IFSFKHQVELSFVIW----AIVLCLIGRACNIFPLAFLVNKFREHKINNKMQFIMWFSG 464

  Fly   597 FRLAFAYLSTYGGNLSRKERAYITIS 622
            .|.|.:|..:...||..:|:.::.|:
  Fly   465 LRGAISYALSLHLNLDSQEKRHVIIT 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	89/416 (21%)
Nhe1	NP_608491.3	Na_H_Exchanger	111..597	CDD:470090	92/435 (21%)