DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nha2 and Slc9a7

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_006256698.1	Gene:	Slc9a7 / 317170	RGDID:	1561385	Length:	727	Species:	Rattus norvegicus

Alignment Length:	538	Identity:	95/538 - (17%)
Similarity:	172/538 - (31%)	Gaps:	154/538 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 WLY--IRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQP------------------PTVIMRI 279
            ||:  .|..:::.:.|..:..:.:|      |:| .|..|                  .|:::.:
  Rat    90 WLFKHRRVRFLHETGLAMIYGLIVG------VIL-RYGTPATSGRDKSLSCTQEDRAFSTLLVNV 147

  Fly   280 AFLF----VGAQISGILVTFVHLPDMLGMLFFGVLYANLGLANFEGYQKFELFLREMALINIMLL 340
            :..|    :..:||...:..|...|||..:.|..                |:|. .:.|..|:..
  Rat   148 SGKFFEYTLKGEISPGKINNVEQNDMLRKVTFDP----------------EVFF-NILLPPIIFH 195

  Fly   341 AGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWG-----------IALGLVI 394
            ||..|....|.|....||....|.|.|....|..|....:.:..:.|           :..|.:|
  Rat   196 AGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFFGAII 260

  Fly   395 TAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQVLQG 459
            :|..|..|:.:..:|..|     ..::.|::..:..||.|||         :.|::.:..|
  Rat   261 SATDPVTVLAIFNELHAD-----VDLYALLFGESVLNDAVAI---------VLSSSIVAYQ---- 307

  Fly   460 PIGI------------GIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVIGY 512
            |.|:            .:|:..|...||.                    .:|....|:.:.|..:
  Rat   308 PAGLNTHAFDAAAFFKSVGIFLGIFSGSF--------------------TMGAVTGVVTALVTKF 352

  Fly   513 TSAGALGCVTTAFIARIGWRR--------------------EETRLTPQQLQAQQIASVPKRLDL 557
            |.......:.||....:.|..                    .:...|...|..:..:...:..::
  Rat   353 TKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRSKQLFEV 417

  Fly   558 MWKFLKPVSFALIGKEINFNVLQGHVIG----YGALLVLVGSLFRLAFAYLSTYGGNLSRKERA- 617
            :....:...|:.:|  :.....|.||..    .||.:.:.  |.|.|..|..::..||.|:.:.
  Rat   418 LHFLAENFIFSYMG--LALFTFQKHVFSPIFIIGAFVAIF--LGRAAHIYPLSFFLNLGRRHKIG 478

  Fly   618 -----YITISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF---TAPLGA 674
                 .:..||.        .|.:|..:|...:.:...|:.....|||:.....:.   |.|:.:
  Rat   479 WNFQHMMMFSGL--------RGAMAFALAIRDTASYSRQMMFTTTLLIVFFTVWVIGGGTTPMLS 535

  Fly   675 ILMLRLAPYWLKHGDAVE 692
            .|.:|:....|...|..|
  Rat   536 WLNIRVGVEELSEEDQNE 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	82/466 (18%)
Slc9a7	XP_006256698.1	Na_H_Exchanger	177..536	CDD:279355	73/425 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900