Protein Alignment Nha2 and Slc9a7

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_001387931.1
• Gene: Slc9a7 / 317170
• RGDID: 1561385
• Length: 727
• Species: Rattus norvegicus
• Alignment Length: 538
• Identity: 95/538 - (17%)
• Similarity: 172/538 - (31%)
• Gaps: 154/538 - (28%)

  Fly   235 WLY--IRSHWVNTSELVALLAIFLGLWAMGWVLLPEYSQP------------------PTVIMRI 279
            ||:  .|..:::.:.|..:..:.:|      |:| .|..|                  .|:::.:
  Rat    90 WLFKHRRVRFLHETGLAMIYGLIVG------VIL-RYGTPATSGRDKSLSCTQEDRAFSTLLVNV 147

  Fly   280 AFLF----VGAQISGILVTFVHLPDMLGMLFFGVLYANLGLANFEGYQKFELFLREMALINIMLL 340
            :..|    :..:||...:..|...|||..:.|..                |:|. .:.|..|:..
  Rat   148 SGKFFEYTLKGEISPGKINNVEQNDMLRKVTFDP----------------EVFF-NILLPPIIFH 195

  Fly   341 AGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWG-----------IALGLVI 394
            ||..|....|.|....||....|.|.|....|..|....:.:..:.|           :..|.:|
  Rat   196 AGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFFGAII 260

  Fly   395 TAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQVLQG 459
            :|..|..|:.:..:|..|     ..::.|::..:..||.|||         :.|::.:..|
  Rat   261 SATDPVTVLAIFNELHAD-----VDLYALLFGESVLNDAVAI---------VLSSSIVAYQ---- 307

  Fly   460 PIGI------------GIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVIGY 512
            |.|:            .:|:..|...||.                    .:|....|:.:.|..:
  Rat   308 PAGLNTHAFDAAAFFKSVGIFLGIFSGSF--------------------TMGAVTGVVTALVTKF 352

  Fly   513 TSAGALGCVTTAFIARIGWRR--------------------EETRLTPQQLQAQQIASVPKRLDL 557
            |.......:.||....:.|..                    .:...|...|..:..:...:..::
  Rat   353 TKLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRSKQLFEV 417

  Fly   558 MWKFLKPVSFALIGKEINFNVLQGHVIG----YGALLVLVGSLFRLAFAYLSTYGGNLSRKERA- 617
            :....:...|:.:|  :.....|.||..    .||.:.:.  |.|.|..|..::..||.|:.:.
  Rat   418 LHFLAENFIFSYMG--LALFTFQKHVFSPIFIIGAFVAIF--LGRAAHIYPLSFFLNLGRRHKIG 478

  Fly   618 -----YITISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF---TAPLGA 674
                 .:..||.        .|.:|..:|...:.:...|:.....|||:.....:.   |.|:.:
  Rat   479 WNFQHMMMFSGL--------RGAMAFALAIRDTASYSRQMMFTTTLLIVFFTVWVIGGGTTPMLS 535

  Fly   675 ILMLRLAPYWLKHGDAVE 692
            .|.:|:....|...|..|
  Rat   536 WLNIRVGVEELSEEDQNE 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	82/466 (18%)
Slc9a7	NP_001387931.1	Na_H_Exchanger	94..>553	CDD:470090	92/532 (17%)