Protein Alignment Nha2 and Slc9a5

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: XP_006531127.1
• Gene: Slc9a5 / 277973
• MGIID: 2685542
• Length: 971
• Species: Mus musculus
• Alignment Length: 605
• Identity: 118/605 - (19%)
• Similarity: 205/605 - (33%)
• Gaps: 201/605 - (33%)

  Fly   197 AGNSSTTTSTNTNYGPGSVSGYPTPNATPGDEYKGPKW-WLYIRSHWVNTSELVALLAIFLGLWA 260
            ||..:|...|..: ||   .|.|.|.....      :| |     |.|....||||
Mouse    15 AGAGATEEPTQES-GP---LGEPPPGLALF------RWQW-----HEVEAPYLVAL--------- 55

  Fly   261 MGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLPD-----MLGMLFFGVLYANLGLANFE 320
              |:|:..       :.:|.| .:..:::.:      :|:     :||::..|::   |.:|...
Mouse    56 --WILVAS-------LAKIVF-HLSRKVTSL------VPESCLLILLGLVLGGIV---LAVAKKA 101

  Fly   321 GYQ----KFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTL--LPTIVEVAAIAGLANLT 379
            .||    .|.|||    |..|:|.:|           :||..||..  |..|:..|.:..|.|..
Mouse   102 EYQLEPGTFFLFL----LPPIVLDSG-----------YFMPSRLFFDNLGAILTYAVVGTLWNAF 151

  Fly   380 LSMPWLWG------------------IALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYA 426
            .:...|||                  :..|.:|:||.|..|:.|.     :.:.:|..:..:|:.
Mouse   152 TTGVALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVF-----EEVHVNQTLFIIIFG 211

  Fly   427 MTTCNDVVAIFMFGVIISVIFSTTSLTQ--QVLQGPI--------GIGIGLVFGYLYGSMLQYLP 481
            .:..||.|.:.::.|..|.:...::..|  ..|:|..        |..:||||.:|.....:: .
Mouse   212 ESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRF-T 275

  Fly   482 SRNATYANGLRFVLTILGGTIAVMG--SRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQ 544
            .|.......|.|:|.......|.|.  |.::..|..| |||               .:.....:.
Mouse   276 KRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCG-LGC---------------KKYVEANIS 324

  Fly   545 AQQIASVPKRLDLMWKFLKPVSFALIGKEINFNVLQGHVIGYGALLVLVGSLFRLAF-------- 601
            .:...:|...:..:....:.|.|.|:|    .:.:......:.:.||| |:||.:.|
Mouse   325 HKSRTAVKYTMKTLASCAETVIFMLLG----ISAVDSSKWAWDSGLVL-GTLFFILFFRALGIAG 384

  Fly   602 ------AYLSTYGG---------------------------NLSRKERAYITISGFPKATVQAAL 633
                  .:||....                           .|::...|.:.:|..|.:.:..||
Mouse   385 ALCSPVPFLSPLAAPHPLSPSSHPHQFPCLPAALTCPDPCQTLAQMLGAGLPVSSTPNSLLPLAL 449

  Fly   634 GPV--------ALDMARAASVASPEQL---------ALAGNLLII---------------SVLAI 666
            .|.        ||:..|...:...:|:         |:|..|:|:               :::.:
Mouse   450 PPAVGVVLQTWALNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVV 514

  Fly   667 IFTAPLGAILMLRLAPYWLK 686
            .||..:..:.:..|.. ||:
Mouse   515 FFTVIVQGLTIKPLVK-WLR 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	98/520 (19%)
Slc9a5	XP_006531127.1	Na_H_Exchanger	44..706	CDD:470090	108/566 (19%)