DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nha2 and Slc9a2

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001106806.1	Gene:	Slc9a2 / 24783	RGDID:	3719	Length:	813	Species:	Rattus norvegicus

Alignment Length:	491	Identity:	93/491 - (18%)
Similarity:	173/491 - (35%)	Gaps:	159/491 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PGSVSGYPTPNATPGDEYKGPKW---------------WLYIRS---------HWVNTSELVALL 252
            |.|.:....|..||.:|.:.|.:               |:.:.|         |.:.|....:.|
  Rat    50 PPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCL 114

  Fly   253 AIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLP-----DMLGMLFF----G 308
            .|.:||...|.:...:...||.:...:.||::...|  :|.....:|     :.||.:|:    |
  Rat   115 LIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPI--VLDAGYFMPTRPFFENLGTIFWYAVVG 177

  Fly   309 VLYANLGLANFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIA 373
            .|:.::|:                         ||.|.|                  |.::.|.
  Rat   178 TLWNSIGI-------------------------GLSLFG------------------ICQIEAF- 198

  Fly   374 GLANLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFM 438
            ||:::||    |..:..|.:|:||.|..|:.|.     :.:.:|..::.|::..:..||.|.:.:
  Rat   199 GLSDITL----LQNLLFGSLISAVDPVAVLAVF-----ENIHVNEQLYILVFGESLLNDAVTVVL 254

  Fly   439 FGVIISVIFSTTSLTQQVLQGPIG---IGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTI--- 497
            :.:..|.....|..|..|..|...   :|||   |.|.|.:|.::.:....:.:.:|.:..:
  Rat   255 YNLFKSFCQMKTIQTVDVFAGIANFFVVGIG---GVLIGILLGFIAAFTTRFTHNIRVIEPLFVF 316

  Fly   498 --------------LGGTIAVMGSRVI------------GYTSAGALGCVTTAFIARIGWRREET 536
                          |.|.:|:....:.            .||        |..:..::.....||
  Rat   317 LYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYT--------TIKYFMKMLSSVSET 373

  Fly   537 RLTPQQLQAQQIASVPKRLDLMWKFL-KPVSFALIGKEINFNVL---------------QGHVIG 585
            .:    .....:::|.|..:..|.|: ..::|.||.:.:...||               ...:|.
  Rat   374 LI----FIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIA 434

  Fly   586 YGALLVLVGSL-FRLAFAYLSTYGGNLSRKERAYIT 620
            ||.|.   |:: |.|.|...:|    :..:::.:||
  Rat   435 YGGLR---GAICFALVFLLPAT----VFPRKKLFIT 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	75/400 (19%)
Slc9a2	NP_001106806.1	b_cpa1	75..631	CDD:273294	86/466 (18%)
		Na_H_Exchanger	85..485	CDD:279355	86/456 (19%)
		NEXCaM_BD	579..685	CDD:293250
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..709
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..813
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900