Protein Alignment Nha2 and SLC9A8

DIOPT Version :9

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: XP_011527038.1
• Gene: SLC9A8 / 23315
• HGNCID: 20728
• Length: 630
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 96/519 - (18%)
• Similarity: 172/519 - (33%)
• Gaps: 189/519 - (36%)

  Fly   282 LFVGAQISGILVTFVH---------LPDMLGMLFFGVLYANL-------GLANFEGYQKFE---L 327
            :|....:..|.:..||         ||:.:.::..|:|...:       .|||::..:.|.   .
Human    62 IFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMF 126

  Fly   328 FLREMALINIMLLAGLGL-DGDAFKRL----------------------------WFMILRLTLL 363
            ||  :.|..|:..:|..| .|:.|:.:                            :|.:.....:
Human   127 FL--LLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQGFFFVCVCVFV 189

  Fly   364 PTIVEVAAIAGLANLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMT 428
            ..|::...|:.| |:|.|      .|.|.:|:||.|...:.:...|..|.:     ::.|::..:
Human   190 CFILQADVISKL-NMTDS------FAFGSLISAVDPVATIAIFNALHVDPV-----LNMLVFGES 242

  Fly   429 TCNDVVAIFM--------------FGVIISVI------------FSTTSLTQQVLQGPIG----- 462
            ..||.|:|.:              ..::|.:|            ..|..||::.:....|
Human   243 ILNDAVSIVLTNTEEKYAPGSCCHLSLVIRIIPGFEEVYFINDHLQTEGLTRKNMSDVSGWQTFL 307

  Fly   463 -------------IGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTI--------------LGG 500
                         ..:|.:.|.:...:|:::..|...   .|.|.:.|              |.|
Human   308 QALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTP---SLEFGMMIIFAYLPYGLAEGISLSG 369

  Fly   501 TIAVMGSRVI--GYTSAGALGCVTTAFIARIGWRREETRLTP--QQLQAQQIASVPKRLDLMWKF 561
            .:|::.|.::  .||                     ...|:|  |.|..|.:.:|        .|
Human   370 IMAILFSGIVMSHYT---------------------HHNLSPVTQILMQQTLRTV--------AF 405

  Fly   562 L-KPVSFALIGK---------EINFNVLQGHVIGYGALLVLVG---SLFRLAFAYLSTYGGNLSR 613
            | :...||.:|.         ||:|.:       :..:|||.|   ::|.|::.........::.
Human   406 LCETCVFAFLGLSIFSFPHKFEISFVI-------WCIVLVLFGRAVNIFPLSYLLNFFRDHKITP 463

  Fly   614 KERAYITISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF-----TAPL 672
            |....:..||...|.      |.||.:  ...:...|:..|.|...|:.||..|.     |.||
Human   464 KMMFIMWFSGLRGAI------PYALSL--HLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	96/519 (18%)
SLC9A8	XP_011527038.1	NhaP	60..533	CDD:223104	96/519 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900