DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nha2 and Slc9c1

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_932774.3	Gene:	Slc9c1 / 208169	MGIID:	2685456	Length:	1175	Species:	Mus musculus

Alignment Length:	510	Identity:	97/510 - (19%)
Similarity:	188/510 - (36%)	Gaps:	121/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 NATPGDEYKGPKWWL-YIRSHWVNT----SELVALLAIFLGLWAMGWVLLPEYSQP-PTVIMRIA 280
            |.|.....|....|| .::|.:::|    .|::.:|::...:.|...:.|.::..| |.::..|.
Mouse     9 NLTASHSIKLTNMWLELLKSVFLSTPQDLPEIILILSLICTVGAFLNMHLKDFPIPLPVILFLIG 73

  Fly   281 FLFVGAQISGILVTFVHL---------PDMLGMLFFGVLYANLGLANFEGYQKFELFLREMA--- 333
            ..|   :|.....|.:.:         ||:...:|..|:..|:.. :.:.|...:||.:.:.
Mouse    74 CCF---EILSFASTQIQIYADAIQWMDPDIFFGIFTPVIIFNVAF-DMDIYMLQKLFWQILVITI 134

  Fly   334 ---LINIMLLAGLGLDGDAFKRLWFM--ILRLTLLPTIVEVAAIAGLANLTLSMPWLWGIALGLV 393
               |||..|:            ||::  :.:|:|                 .::|||   ....|
Mouse   135 PGFLINYTLI------------LWYLQSVNKLSL-----------------KTVPWL---LFSAV 167

  Fly   394 ITAVSPNVVVTVMLKLKEDR-LGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQVL 457
            :.:..|      ||.....| |||:..:..||...:....|:::.::..::.:.|.:.|:...:.
Mouse   168 LISSDP------MLTSASIRDLGLSRSLTNLINGESLLTSVLSLVIYSGVVHIRFKSKSVNHTLA 226

  Fly   458 QGPIG-----IGIGLVFGYLYGSMLQ-YLPSRNATYANGLRFVLTILGGTIAVMGSRVIGYTS-- 514
            ...:.     |....:.|.::..::| ::.:......|.:..:.::|         .:|.|..
Mouse   227 HKVMSTAWSYIVESFITGIVFTKVIQLWMATIFGDDVNHITLIFSVL---------YLIFYVCEL 282

  Fly   515 AGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFALIGK------- 572
            .|..|..|   :|.||.....|...|         .|...|...|..|..:.|.::..
Mouse   283 VGMSGIFT---LATIGLFLNSTSFKP---------GVEAFLLEFWNCLSFIGFLMVFTFIGLLIP 335

  Fly   573 -----EINFNVLQGHVIGYGALLVLVGSLFRLAFAYLSTYGGNLSRKERAYITISGFPKAT---- 628
                 .|:|:.:...:..|..|:||...:|.|....||..|...|.: .|:|.:....|.|
Mouse   336 AHTYLHISFSDVYYSLNIYFTLIVLRLLVFLLMSPILSRLGHGFSWR-WAFIMVWSEMKGTPNIN 399

  Fly   629 --VQAALGPVALDMARAASVASPEQLALAG-NLLIISVLAIIFTAPLGAILMLRL 680
              :..|...::|...|..|     |:...| ::.:|:::...|..|: |:..|.|
Mouse   400 MALLLAYSDISLGSERERS-----QILFHGVSVCVITLIVNRFILPM-AVTKLGL 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	84/447 (19%)
Slc9c1	NP_932774.3	Na_H_Exchanger	40..459	CDD:294713	89/479 (19%)
		Ion transport-like	618..698
		Crp	885..>1035	CDD:223736
		CAP_ED	895..1019	CDD:237999
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1137..1175
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900