Protein Alignment Nha2 and Slc9a1

DIOPT Version :10

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_058677.1
• Gene: Slc9a1 / 20544
• MGIID: 102462
• Length: 820
• Species: Mus musculus
• Alignment Length: 441
• Identity: 92/441 - (20%)
• Similarity: 149/441 - (33%)
• Gaps: 171/441 - (38%)

  Fly   126 APGDNMTQGAAP--QDSQGDI--LPTRPLHTKLDIQKIPEDEAGADATQNAATIILTPTSLNLTN 186
            :|..:..:|:.|  :.|.||:  .|:.|||.       |:|.                   ||||
Mouse    41 SPTASTIRGSEPPRERSIGDVTTAPSEPLHR-------PDDH-------------------NLTN 79

  Fly   187 TTTQNVAANNAGNSSTTTSTNTNYGPGSVSGYPTPNATPGDEYKGPKWWLYIRSHWVNTSELVAL 251
            ...::                        .|.|:..|.|..:...|.         |.|...::|
Mouse    80 LIIEH------------------------GGKPSRKAFPVLDIDYPH---------VRTPFEISL 111

  Fly   252 LAIFLGLWAMGWVLLPEYSQ--PPTVIMRIAFLFVGAQISGILVTFVHLPDMLGMLFFGVLYANL 314
            ..:...|..:|:.::|..|.  |.:.::.:..|.||..|.|:..|   .|.:...:||
Mouse   112 WILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGET---PPFLQSDVFF------- 166

  Fly   315 GLANFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLWFMILR--LTLLPTIVEVAAIAGLAN 377
                        |||    |..|:|.||           :|:.||  ...|.||:..|.:..|.|
Mouse   167 ------------LFL----LPPIILDAG-----------YFLPLRQFTENLGTILIFAVVGTLWN 204

  Fly   378 LTLSMPWLWGIAL-----------------GLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIY 425
            .......|:.:.|                 |.:|:||.|..|:.|.     :.:.:|..:|.|::
Mouse   205 AFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVF-----EEIHINELLHILVF 264

  Fly   426 AMTTCNDVVAIFMF----------GVIISVIFSTTSLTQQVLQGPIGIGIGLVFG---------- 470
            ..:..||.|.:.::          .|.||.||........|..|  |:.:|:|:|
Mouse   265 GESLLNDAVTVVLYHLFEEFASYDSVGISDIFLGFLSFFVVALG--GVFVGVVYGVIAAFTSRFT 327

  Fly   471 -----------YLYGSMLQYLPSRNATYANGLRFVLTILGGTIAVMGSRVI 510
                       :|| |.:.||.:.           |..|.|.:|::.|.|:
Mouse   328 SHIRVIEPLFVFLY-SYMAYLSAE-----------LFHLSGIMALIASGVV 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	NhaP	279..>686	CDD:439796	63/282 (22%)
Slc9a1	NP_058677.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..74		11/39 (28%)
		b_cpa1	99..664	CDD:273294	72/333 (22%)
		Interaction with TESC. /evidence=ECO:0000250|UniProtKB:P19634	507..549
		PI(4,5)P2-binding region. /evidence=ECO:0000250|UniProtKB:P26431	513..520
		Interaction with CHP2. /evidence=ECO:0000250|UniProtKB:P19634	519..549
		Confers pH-dependent PI(4,5)P2 binding. /evidence=ECO:0000250|UniProtKB:P19634	544..549
		PI(4,5)P2-binding region. /evidence=ECO:0000250|UniProtKB:P26431	556..564
		Interaction with CALM1. /evidence=ECO:0000250|UniProtKB:P19634	637..820
		Interaction with TESC. /evidence=ECO:0000250|UniProtKB:P19634	637..820
		Interaction with PPP3CA. /evidence=ECO:0000250|UniProtKB:P19634	688..691
		Interaction with PPP3CA. /evidence=ECO:0000250|UniProtKB:P19634	719..724
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..820