DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nha2 and Slc9a5

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_620213.1	Gene:	Slc9a5 / 192215	RGDID:	620473	Length:	898	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	107/537 - (19%)
Similarity:	189/537 - (35%)	Gaps:	149/537 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 PG----SVSGYPTPNATPGDEYKGP-----KW-WLYIRSHWVNTSELVALLAIFLGLWAMGWVLL 266
            ||    .|.....|...||...:.|     :| |     |.|....||||           |:|:
  Rat    10 PGLPLAGVGATEEPTQEPGPLGEPPGLALFRWQW-----HEVEAPYLVAL-----------WILV 58

  Fly   267 PEYSQPPTVIMRIAFLFVGAQISGILVTFVHLPD-----MLGMLFFGVLYANLGLANFEGYQ--- 323
            ..       :.:|.| .:..:::.:      :|:     :||:...|::   |.:|....||
  Rat    59 AS-------LAKIVF-HLSRKVTSL------VPESCLLILLGLALGGIV---LAVAKKAEYQLEP 106

  Fly   324 -KFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTL--LPTIVEVAAIAGLANLTLSMPWL 385
             .|.|||    |..|:|.:|           :||..||..  |..|:..|.:..|.|...:...|
  Rat   107 GTFFLFL----LPPIVLDSG-----------YFMPSRLFFDNLGAILTYAVVGTLWNAFTTGVAL 156

  Fly   386 WG------------------IALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCND 432
            ||                  :..|.:|:||.|..|:.|.     :.:.:|..:..:::..:..||
  Rat   157 WGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVF-----EEVHVNETLFIIVFGESLLND 216

  Fly   433 VVAIFMFGVIISVIFSTTSLTQ--QVLQGPI--------GIGIGLVFGYLYGSMLQYLPSRNATY 487
            .|...::.|..|.:...::..|  ..|:|..        |..:||||.:|.....:: ..|....
  Rat   217 AVTAVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRF-TKRVRII 280

  Fly   488 ANGLRFVLTILGGTIAVMG--SRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIAS 550
            ...|.|:|.......|.|.  |.::..|..| |||               .:.....:..:...:
  Rat   281 EPLLVFLLAYAAYLTAEMASLSAILAVTMCG-LGC---------------KKYVEANISHKSRTA 329

  Fly   551 VPKRLDLMWKFLKPVSFALIGKEINFNVLQGHVIGYGALLVLVGSLFRLAF-----AYLSTYGGN 610
            |...:..:....:.|.|.|:|    .:.:......:.:.||| |:||.:.|     ..|.|:..|
  Rat   330 VKYTMKTLASSAETVIFMLLG----ISAVDSSKWAWDSGLVL-GTLFFILFFRALGVVLQTWVLN 389

  Fly   611 ------LSRKERAYITISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIFT 669
                  |.:.::..::..|...|...|.:  :.||..:..          |.:..:.:.:.::|.
  Rat   390 QFRLAPLDKIDQVVMSYGGLRGAVAFALV--ILLDRTKVP----------AKDYFVATTIVVVFF 442

  Fly   670 APLGAILMLRLAPYWLK 686
            ..:...|.::....||:
  Rat   443 TVIVQGLTIKPLVKWLR 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	89/458 (19%)
Slc9a5	NP_620213.1	b_cpa1	43..632	CDD:273294	99/504 (20%)
		Na_H_Exchanger	52..457	CDD:279355	93/486 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..692
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..888
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900