Protein Alignment Nha2 and slc-9B.1

DIOPT Version :9

• Sequence 1: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Sequence 2: NP_509724.1
• Gene: slc-9B.1 / 181236
• WormBaseID: WBGene00009617
• Length: 516
• Species: Caenorhabditis elegans
• Alignment Length: 504
• Identity: 125/504 - (24%)
• Similarity: 226/504 - (44%)
• Gaps: 64/504 - (12%)

  Fly   186 NTTTQNVAANNAGNSSTTTSTNTNYGPGSVSGYPTPNATPGDEYKGPKWWLYIRSHWVN----TS 246
            :.|..|...|...||.|||...      .:|.|.:.....|:.:..|     :..| ||    |:
 Worm     8 HNTLHNFFNNREINSITTTILI------FISLYISIITLLGENFLNP-----LADH-VNPVNATN 60

  Fly   247 ELVALLAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLPDMLGMLFFGVLY 311
            |.|.:.:||:                 ..|:.:|.:| .|:||..|    .||.:.|.|..|::.
 Worm    61 EDVTVRSIFV-----------------IFILLVAGIF-AAKISKAL----RLPPLFGCLALGIII 103

  Fly   312 ANLGLANFEGYQKF----ELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAI 372
            .|:.:  |:.:..|    |..:|::||:.|::..||..|.........|.:.:.|:..|.|:.|:
 Worm   104 KNITV--FDQFFVFPPFVETMIRKVALVMIIVRWGLATDIHFLYENALMPVTIGLVTAIGEIIAV 166

  Fly   373 AGLANLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIF 437
            ...:...|::.::..|...|::..|||.|.|..|:..||.:||....|...|.|:...:::..:.
 Worm   167 TIASYFILNISFVMSIFCALILVTVSPAVTVPAMINFKEKQLGSLKRIPENILAICCVDNLFCVI 231

  Fly   438 MFGVIISVIFSTTSLTQQVLQGPIGIGIGLVFGYLYGSMLQYLPSRNATYANGLRFVLTILGGTI 502
            :|.|:.|:||:...:...:|.....|..|.:.|.:.|.:|...|..:|.:....|  :|:| |||
 Worm   232 LFMVLSSIIFTDAPIATTILLNAGSIVFGCIGGIVLGWILWRFPRSDAPHTQFAR--ITLL-GTI 293

  Fly   503 ---AVMGSRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASVPKRLDLMW-KFLK 563
               .|:|:.:|.|:.:|.|..:.|:.::.:.|:.:         ..:::..|......:| .|..
 Worm   294 CIAVVIGTYLIKYSCSGFLAALITSAMSAMQWKAD---------NKEKLECVESTYKYIWDSFAL 349

  Fly   564 PVSFALIGKEINFNVLQGHVIGYGALLVLVGSLFRLAFAYLSTYGGNLSRKERAYITISGFPKAT 628
            |:.|..:|.:.:.:.|...::.....::.:|.|.|.....|.|...:::.||:..:.:|..|:||
 Worm   350 PLLFICLGMKFDCSTLTWEIVFLCIAVIAIGLLVRTILVMLVTLSSHINFKEQIVVALSLLPRAT 414

  Fly   629 VQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIFTAPLGAILM 677
            .||.|.|..|.||    ...|:....|..:|..::|:::.|||:..||:
 Worm   415 FQADLAPTLLLMA----TPFPDMAKDAALILKAAILSVLITAPIFDILL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	104/407 (26%)
slc-9B.1	NP_509724.1	Na_H_Exchanger	68..455	CDD:382399	105/426 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159332
Domainoid	1	1.000	137	1.000	Domainoid score	I3031
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I2955
Isobase	1	0.950	-	0	Normalized mean entropy	S5939
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D406317at33208
OrthoFinder	1	1.000	-	-		FOG0001578
OrthoInspector	1	1.000	-	-		mtm4756
orthoMCL	1	0.900	-	-		OOG6_103025
Panther	1	1.100	-	-	O	PTHR31102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4408
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.740