DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nha2 and SLC9B1

DIOPT Version :9

Sequence 1:	NP_001247251.1	Gene:	Nha2 / 42710	FlyBaseID:	FBgn0263390	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_631912.3	Gene:	SLC9B1 / 150159	HGNCID:	24244	Length:	515	Species:	Homo sapiens

Alignment Length:	553	Identity:	161/553 - (29%)
Similarity:	256/553 - (46%)	Gaps:	65/553 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 LHTKLDIQKIPEDEAGADATQNAATIILTPTSLNLTNTTTQNVAANNAGNSSTTTSTNTNYGPGS 214
            :||.....:..|||....:|        ||.||...|.|.|.       .:.|..|......|
Human     1 MHTTESKNEHLEDENFQTST--------TPQSLIDPNNTAQE-------ETKTVLSDTEEIKP-- 48

  Fly   215 VSGYPTPNATPGDEYKGPKWWLYIRSHWVNTSELVALLAIFL-GLWAMGWVLLPEYSQPPTVIMR 278
                .|...|            ||.........::....:.| .:|.|.|.:|...:.|...:..
Human    49 ----QTKKET------------YISCPLRGVLNVIITNGVILFVIWCMTWSILGSEALPGGNLFG 97

  Fly   279 IAFLFVGAQISGILVTFVH------LPDMLGMLFFGVLYANLGLANFEGY--QKFELFLREMALI 335
            :..:|..|.|.|.::..:.      ||.:||||..|....|:...|...:  ..:...||.:||.
Human    98 LFIIFYSAIIGGKILQLIRIPLVPPLPPLLGMLLAGFTIRNVPFINEHVHVPNTWSSILRSIALT 162

  Fly   336 NIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLANLTLSMPWLWGIALGLVITAVSPN 400
            .|::.||||||..|.:.|..:..||.:.|.::|.:|.|..::..:..||.|...||.|:.||||.
Human   163 IILIRAGLGLDPQALRHLKVVCFRLAVGPCLMEASAAAVFSHFIMKFPWQWAFLLGFVLGAVSPA 227

  Fly   401 VVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGVIISVIFSTTSLTQQVLQGPIGIGI 465
            |||..|:.|:|:..|:..||.||:.|.::.:|::||..|...:|::||:..:....:.....:.|
Human   228 VVVPYMMVLQENGYGVEEGIPTLLMAASSMDDILAITGFNTCLSIVFSSGGILNNAIASIRNVCI 292

  Fly   466 GLVFGYLYGSMLQYLPS---RNATYANGLRFVLTILGGTIAVMGSRVIGYTSAGALGCVTTAFIA 527
            .|:.|.:.|..::|.||   :..|...|. .|||:.  ..||:||:.||...:|.|..:..:|||
Human   293 SLLAGIVLGFFVRYFPSEDQKKLTLKRGF-LVLTMC--VSAVLGSQRIGLHGSGGLCTLVLSFIA 354

  Fly   528 RIGWRREETRLTPQQLQAQQIASVPKRLDLMWKFLKPVSFALIGKEINFNVLQGHVIGYGALLVL 592
            ...|.:|:.:             |.|.:..:|...:|:.|.|:|.|::.:.|:.:::|.....:.
Human   355 GTKWSQEKMK-------------VQKIITTVWDIFQPLLFGLVGAEVSVSSLESNIVGISVATLS 406

  Fly   593 VGSLFRLAFAYLSTYGGNLSRKERAYITISGFPKATVQAALGPVALDMARAASVASPEQLALAGN 657
            :....|:...||.......|.||:.:|.::..|||||||.|||:||:.||   |::|.....|.:
Human   407 LALCVRILTTYLLMCFAGFSFKEKIFIALAWMPKATVQAVLGPLALETAR---VSAPHLEPYAKD 468

  Fly   658 LLIISVLAIIFTAPLGAILMLRLAPYWL-KHGD 689
            ::.::.|||:.|||.||:||..|.|..| :|.|
Human   469 VMTVAFLAILITAPNGALLMGILGPKMLTRHYD 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	133/418 (32%)
SLC9B1	NP_631912.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		11/38 (29%)
SLC9B1	NP_631912.3	Na_H_Exchanger	140..480	CDD:351397	111/358 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D406317at33208
OrthoFinder	1	1.000	-	-		FOG0001578
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103025
Panther	1	1.100	-	-	O	PTHR31102
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4408
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.740