DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nha2 and Slc9a4

DIOPT Version :9

Sequence 1:NP_001247251.1 Gene:Nha2 / 42710 FlyBaseID:FBgn0263390 Length:714 Species:Drosophila melanogaster
Sequence 2:NP_796058.1 Gene:Slc9a4 / 110895 MGIID:105074 Length:797 Species:Mus musculus


Alignment Length:465 Identity:89/465 - (19%)
Similarity:175/465 - (37%) Gaps:122/465 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 LAIFLGLWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTFVHLP-----DMLGMLFFGVLY 311
            |.|.:|....|.:....:..||.:...|.||::...|  :|.:...:|     :.:|.:.:   :
Mouse   102 LLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPI--VLESGYFMPTRPFFENIGSILW---W 161

  Fly   312 ANLGLANFEGYQKFELFLREMALINIMLLAGLGLDGDAFKRLWFMILRLTLLPTIVEVAAIAGLA 376
            |.||                 ||||..   |:||.      |:|          |.::.|. ||.
Mouse   162 AGLG-----------------ALINAF---GIGLS------LYF----------ICQIKAF-GLG 189

  Fly   377 NLTLSMPWLWGIALGLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDVVAIFMFGV 441
            ::.|    |..:..|.:|:||.|   |.|:...:|.|  :|..::.:|:.....||.:::.::.:
Mouse   190 DINL----LHNLLFGSLISAVDP---VAVLAVFEEAR--VNEQLYMMIFGEALLNDGISVVLYNI 245

  Fly   442 IIS-----------VIFSTTSLTQQVLQGPIGIGIGLVFGYLYGSMLQYLPSRNA---------T 486
            :|:           .:.......:.|:.|..|:..|::||::...:.::..:.:|         :
Mouse   246 LIAFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFS 310

  Fly   487 YANGLRFVLTILGGTIAVMGSRVIGYTSAGALGCVTT--AFIARIGWRREETRLTPQQLQAQQIA 549
            |.:.|......|.|.:|:             ..|..|  .::..   ...:|..|..:...:.::
Mouse   311 YLSYLAAETLYLSGILAI-------------TACAVTMKKYVEE---NVSQTSYTTIKYFMKMLS 359

  Fly   550 SVPKRLDLMWKFLKPVSFALIGKEINFNVLQGHVIGYGALLVLVGSLFRLAFAYLSTYGGN---- 610
            ||.:.|..::     :..:.|||...:|      ..:....:|...::|....:...|..|    
Mouse   360 SVSETLIFIF-----MGVSTIGKNHEWN------WAFICFTLLFCQIWRAISVFTLFYVSNQFRT 413

  Fly   611 --LSRKERAYITISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAIIF----T 669
              .|.|::..|..||     |:.| |..:|......|:...::|.:... |:::...:.|    .
Mouse   414 FPFSIKDQFIIFYSG-----VRGA-GSFSLAFLLPLSLFPRKKLFVTAT-LVVTYFTVFFQGITI 471

  Fly   670 APLGAILMLR 679
            .||...|.:|
Mouse   472 GPLVRYLDVR 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nha2NP_001247251.1 Na_H_Exchanger 279..686 CDD:294713 83/438 (19%)
Slc9a4NP_796058.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..52
b_cpa1 63..621 CDD:273294 89/465 (19%)
Na_H_Exchanger 73..476 CDD:279355 87/458 (19%)
NEXCaM_BD 569..667 CDD:293250
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..797
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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