DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and USH2A

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_996816.3	Gene:	USH2A / 7399	HGNCID:	12601	Length:	5202	Species:	Homo sapiens

Alignment Length:	725	Identity:	140/725 - (19%)
Similarity:	218/725 - (30%)	Gaps:	300/725 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NANASGLRKSSQRRNRAPLQMNCPILI---------------------------------VISLG 55
            :|:.:||.|.:......||.:|.|:.:                                 |::|
Human  1813 SASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTRGAVVNL- 1876

  Fly    56 WLLHAHAGSGGFAV--------EAAISNRGSNSRSMSNVQQSAVAASTL---TATLPRFLSRGHT 109
                |...||...|        ::|::.||::|..:...::.:|....|   |..|.|.:: .|.
Human  1877 ----ASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGGLQPFTEYLYRVIA-SHE 1936

  Fly   110 YRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLEISDLEPQDAGD 174
            ..:|..|                 |.||.....|...:.| ..|||.::||::|::..||...|.
Human  1937 GGSVYSD-----------------WSRGRTTGAAPQSVPT-PSRVRSLNGYSIEVTWDEPVVRGV 1983

  Fly   175 YVCQISDKINRDQVHTVEILVPP-----SVRAIPTSG------QLQARKGGPITLE------CKG 222
            ....|....:.|...      ||     |...:.||.      .|...|...:||.      |..
Human  1984 IEKYILKAYSEDSTR------PPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTE 2042

  Fly   223 SGN----------------PV----PS---IYWTKKSGANKSTARIGDGPILTLEKLERQQAGVY 264
            |.:                ||    ||   :.|.....||         .|:|...|......:|
Human  2043 SSHALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKAN---------GIITQYCLYMDGRLIY 2098

  Fly   265 QCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSW---YQNSF 326
            ..:.:|.:...:.|       :.|...:..:..|.|        |       ...||   |....
Human  2099 SGSEENYIVTDLAV-------FTPHQFLLSACTHVG--------C-------TNSSWVLLYTAQL 2141

  Fly   327 PIQSTDRRIMATRANRHMLTIRHIQ---------------------QEDFGNYSCVADNS----- 365
            |.:..|..::....:|   || |||                     ..||..:|.:.:::
Human  2142 PPEHVDSPVLTVLDSR---TI-HIQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQD 2202

  Fly   366 ------LGRSRKYMELSGRPG-------AAEFY----------SPK-WGRSPDSYNLTWKIDSYP 406
                  |..::..::|....|       |:|..          :|| ...||||:|::|....||
Human  2203 HMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYP 2267

  Fly   407 P---------LEEV------RLLYR------------RVQM-------------NETYQQP--GR 429
            .         |:.:      .|.||            |||.             |.|.:.|  |.
Human  2268 NGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGT 2332

  Fly   430 WHDFILTPEHRPAS-------EP---LTHIMSYT-IKNLHP-GGYYEAIVQAKNRYG------WN 476
            .:.|:.|...|.|.       .|   |||.:.:| |..:.| |..|..:...|..|.      |.
Human  2333 VNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWV 2397

  Fly   477 EVSDIFQF------VVATNSQ--------------------------DIGPEDAEVVASSKSRSN 509
            .:..:..|      |..:|||                          ...|...:||.|:.:|:|
Human  2398 LIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNN 2462

  Fly   510 SASIGSLPGS 519
            :      |||
Human  2463 A------PGS 2466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	15/71 (21%)
		IG_like	109..195	CDD:214653	18/85 (21%)
		Ig	118..191	CDD:143165	16/72 (22%)
		IG_like	205..274	CDD:214653	19/103 (18%)
		IGc2	213..273	CDD:197706	16/88 (18%)
		IGc2	301..367	CDD:197706	15/100 (15%)
		FN3	392..486	CDD:238020	36/159 (23%)
USH2A	NP_996816.3	LamGL	146..283	CDD:214722
		Laminin_N	291..516	CDD:413488
		EGF_Lam	517..565	CDD:238012
		EGF_Lam	574..639	CDD:238012
		Laminin_EGF	641..691	CDD:395007
		EGF_Lam	694..733	CDD:214543
		Laminin_EGF	747..795	CDD:395007
		EGF_Lam	794..844	CDD:238012
		EGF_Lam	847..897	CDD:214543
		EGF_Lam	900..948	CDD:238012
		EGF_Lam	950..1000	CDD:238012
		EGF_Lam	1001..>1037	CDD:238012
		fn3	1058..1132	CDD:394996
		fn3	1150..1227	CDD:394996
		FN3	1242..1357	CDD:238020
		FN3	1368..1451	CDD:214495
		LamG	1519..1678	CDD:238058
		LamG	1716..1868	CDD:238058	8/54 (15%)
		FN3	1956..2051	CDD:238020	23/101 (23%)
		FN3	2241..2313	CDD:238020	17/71 (24%)
		FN3	2329..2428	CDD:238020	22/98 (22%)
		FN3	2432..2528	CDD:238020	9/41 (22%)
		FN3	2533..2619	CDD:238020
		FN3	2621..2719	CDD:238020
		FN3	2724..2799	CDD:238020
		FN3	2818..2920	CDD:238020
		FN3	2925..3015	CDD:238020
		FN3	3026..>3087	CDD:238020
		FN3	<3449..3494	CDD:238020
		FN3	3503..3586	CDD:238020
		FN3	3590..3676	CDD:238020
		FN3	3680..3767	CDD:238020
		fn3	3777..3856	CDD:394996
		FN3	3866..3960	CDD:238020
		FN3	3964..4057	CDD:238020
		fn3	4161..4247	CDD:394996
		FN3	4268..4351	CDD:238020
		fn3	4357..4428	CDD:394996
		FN3	4444..4516	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4518..4541
		FN3	4529..4627	CDD:238020
		FN3	4636..4730	CDD:238020
		FN3	4826..4927	CDD:238020
		PDZ-binding	5200..5202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900