DRSC/TRiP Functional Genomics Resources

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Protein Alignment klg and Hmcn2

DIOPT Version :10

Sequence 1:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster
Sequence 2:XP_006498564.1 Gene:Hmcn2 / 665700 MGIID:2677838 Length:5092 Species:Mus musculus


Alignment Length:565 Identity:128/565 - (22%)
Similarity:201/565 - (35%) Gaps:141/565 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 GGFAVE---AAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSR--GHTYRAVVGDTLVLPCQV 124
            ||..:|   :..|::|..|..:||....|:....|...:|....:  ..|...|.|.||||.|.|
Mouse  3105 GGQTLEILDSQASDKGVYSCKVSNTAGEAIRTFVLAIQVPPTFEKPERETVNQVAGRTLVLACDV 3169

  Fly   125 ENLGNFVLLWRRGTNVLTASNI--MVTRDERVRLIDGYNLEISDLEPQDAGDYVCQISD---KIN 184
            ..:....:.|.:....:.:|.:  :|:|        |..|::|.|:|..||.|.|...:   :..
Mouse  3170 SGIPAPTVTWLKDRLPVESSVVHGVVSR--------GGRLQLSHLQPAQAGTYTCVAENAQAEAR 3226

  Fly   185 RDQVHTVEILVPPSVRAIPTSGQLQAR---KGGPITLECKGSGNPVPSIYWTKKSGANKSTARIG 246
            :|.|  |.:||||.::   .||..|..   :...|.|.|:..|.|.|.|.|.|..|.  ....:|
Mouse  3227 KDFV--VSVLVPPQIQ---DSGMAQEHNVLEKQEIRLHCEAEGQPPPDITWLKDGGL--LDQHVG 3284

  Fly   247 -------DGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRL---DVLYPPDIQV---EKSWIH 298
                   ||..|.|:.|....:|.|.|.|.|..|:    |.||   :||.||.|:.   :...:.
Mouse  3285 PHLRFYLDGSTLVLKGLRTADSGAYTCVAHNPAGE----DARLHTVNVLVPPTIKQQAGDTGTLV 3345

  Fly   299 SGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMATRANRHMLTIRHIQQEDFGNYSCVAD 363
            |..|....:||.|...|...|||.::..|:..:.|.::  .::...|.|..:|..|.|.::|||.
Mouse  3346 SRTGELVTMVCPVQGSPPIHVSWLKDGLPLPLSQRTLL--HSSGRTLRISQVQLADSGVFTCVAA 3408

  Fly   364 NSLG-RSRKY------------MELSGRPGAA---EFYSPKWGRSPDSYNLTWKIDSYP------ 406
            :..| ..|.:            :|......||   |...|...|......::|..|..|      
Mouse  3409 SPAGVADRNFTLLVLVPPILEPVEFQNNVMAAQGSEVVLPCEARGSPLPLVSWMKDGEPLLPQSL 3473

  Fly   407 ------PLEEVRL----LYRRVQMNETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGG 461
                  .||.|.:    .|.....:|..:....:...::.|.|...|...:.:      :|.||.
Mouse  3474 EQGPGLKLESVSVGDAGTYSCTAASEAGEARRHFQLTVMDPPHIEESGETSEL------SLTPGA 3532

  Fly   462 YYEAIVQAKN----RYGWN-----------------------------------------EVSDI 481
            :.|.:.:|:.    ...|:                                         ||...
Mouse  3533 HLELLCEARGIPPPNITWHKDGQALRRTENDSQAGRVLRVRDVQVDNAGLYTCLAESPAGEVEKS 3597

  Fly   482 FQFVVATNSQDIGPEDAEVVASSKSRSNSASIGSLPGSTVLHTAL 526
            |:..|......:||           |...:.:|..||..:|..::
Mouse  3598 FRVRVQAPPNVVGP-----------RGPRSVVGLAPGQLILECSV 3631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klgNP_524454.2 IG_like 109..195 CDD:214653 25/90 (28%)
Ig strand B 118..122 CDD:409353 3/3 (100%)
Ig strand C 131..135 CDD:409353 0/3 (0%)
Ig strand E 160..164 CDD:409353 1/3 (33%)
Ig strand F 174..179 CDD:409353 2/4 (50%)
Ig strand G 188..191 CDD:409353 1/2 (50%)
Ig_3 196..270 CDD:464046 25/83 (30%)
Ig_3 287..364 CDD:464046 22/79 (28%)
FN3 392..486 CDD:238020 20/154 (13%)
Hmcn2XP_006498564.1 ChlD <3..208 CDD:440853
Ig <449..514 CDD:472250
Ig strand C 458..462 CDD:409405
Ig strand E 480..484 CDD:409405
Ig strand F 494..499 CDD:409405
Ig strand G 507..510 CDD:409405
IG_like 525..605 CDD:214653
Ig strand B 535..539 CDD:409544
Ig strand C 548..552 CDD:409544
Ig strand E 571..575 CDD:409544
Ig strand F 585..590 CDD:409544
Ig strand G 598..601 CDD:409544
I-set 609..693 CDD:400151
Ig strand B 626..630 CDD:409353
Ig strand C 639..643 CDD:409353
Ig strand E 661..665 CDD:409353
Ig strand F 675..680 CDD:409353
Ig strand G 689..692 CDD:409353
IG_like 707..783 CDD:214653
Ig strand B 716..720 CDD:409353
Ig strand C 729..733 CDD:409353
Ig strand E 749..753 CDD:409353
Ig strand F 763..768 CDD:409353
IG_like 793..876 CDD:214653
Ig strand B 804..808 CDD:409390
Ig strand C 817..821 CDD:409390
Ig strand E 842..846 CDD:409390
Ig strand F 856..861 CDD:409390
Ig strand G 869..872 CDD:409390
I-set 889..969 CDD:400151
Ig strand B 899..903 CDD:409550
Ig strand C 913..917 CDD:409550
Ig strand F 949..954 CDD:409550
Ig strand G 962..965 CDD:409550
Ig_3 972..1046 CDD:464046
Ig 1076..1157 CDD:472250
Ig strand B 1087..1091 CDD:409544
Ig strand C 1100..1104 CDD:409544
Ig strand E 1123..1127 CDD:409544
Ig strand F 1137..1142 CDD:409544
Ig strand G 1150..1153 CDD:409544
Ig 1161..1242 CDD:472250
Ig strand B 1178..1182 CDD:409420
Ig strand C 1191..1195 CDD:409420
Ig strand E 1206..1213 CDD:409420
Ig strand F 1222..1227 CDD:409420
Ig strand G 1235..1238 CDD:409420
Ig 1260..1336 CDD:472250
Ig strand B 1265..1269 CDD:409358
Ig strand C 1278..1282 CDD:409358
Ig strand E 1302..1306 CDD:409358
Ig strand F 1316..1321 CDD:409358
Ig strand G 1329..1332 CDD:409358
I-set 1345..1429 CDD:400151
Ig strand B 1359..1363 CDD:409353
Ig strand C 1372..1376 CDD:409353
Ig strand E 1395..1399 CDD:409353
Ig strand F 1409..1414 CDD:409353
Ig strand G 1422..1425 CDD:409353
I-set 1449..1523 CDD:400151
Ig strand B 1452..1456 CDD:409544
Ig strand C 1465..1469 CDD:409544
Ig strand E 1488..1493 CDD:409544
Ig strand F 1503..1508 CDD:409544
IG_like 1553..1633 CDD:214653
Ig strand B 1563..1567 CDD:409353
Ig strand C 1576..1580 CDD:409353
Ig strand E 1599..1603 CDD:409353
Ig strand F 1613..1618 CDD:409353
Ig 1643..1728 CDD:472250
Ig strand B 1657..1661 CDD:409400
Ig strand C 1670..1674 CDD:409400
Ig strand E 1692..1696 CDD:409400
Ig strand F 1706..1711 CDD:409400
Ig strand G 1721..1724 CDD:409400
Ig 1741..1819 CDD:472250
Ig strand B 1749..1753 CDD:409353
Ig strand C 1762..1766 CDD:409353
Ig strand E 1784..1789 CDD:409353
Ig strand F 1799..1804 CDD:409353
Ig strand G 1812..1815 CDD:409353
Ig 1839..1903 CDD:472250
Ig strand B 1841..1845 CDD:409353
Ig strand C 1854..1858 CDD:409353
Ig strand E 1869..1873 CDD:409353
Ig strand F 1883..1888 CDD:409353
I-set 1907..1986 CDD:400151
Ig strand B 1924..1928 CDD:409562
Ig strand C 1937..1941 CDD:409562
Ig strand E 1960..1964 CDD:409562
Ig strand F 1974..1979 CDD:409562
Ig strand G 1987..1990 CDD:409562
Ig_3 1997..2073 CDD:464046
Ig_3 2091..2166 CDD:464046
Ig 2183..2273 CDD:472250
Ig strand B 2201..2205 CDD:409420
Ig strand C 2214..2218 CDD:409420
Ig strand E 2239..2243 CDD:409420
Ig strand F 2253..2258 CDD:409420
Ig strand G 2266..2269 CDD:409420
Ig 2291..2367 CDD:472250
Ig strand B 2297..2301 CDD:409544
Ig strand C 2310..2314 CDD:409544
Ig strand E 2333..2337 CDD:409544
Ig strand F 2347..2352 CDD:409544
Ig strand G 2360..2363 CDD:409544
Ig 2380..2461 CDD:472250
Ig strand B 2391..2395 CDD:409353
Ig strand C 2404..2408 CDD:409353
Ig strand E 2426..2431 CDD:409353
Ig strand F 2441..2446 CDD:409353
Ig strand G 2454..2457 CDD:409353
I-set 2476..2554 CDD:400151
Ig strand B 2484..2488 CDD:409353
Ig strand C 2497..2501 CDD:409353
Ig strand E 2520..2524 CDD:409353
Ig strand F 2534..2539 CDD:409353
I-set 2558..2650 CDD:400151
Ig strand B 2580..2584 CDD:409393
Ig strand C 2593..2597 CDD:409393
Ig strand E 2617..2620 CDD:409393
Ig strand F 2630..2635 CDD:409393
Ig strand G 2643..2646 CDD:409393
I-set 2668..2740 CDD:400151
Ig strand B 2678..2682 CDD:409353
Ig strand C 2691..2695 CDD:409353
Ig strand E 2714..2718 CDD:409353
Ig strand F 2728..2733 CDD:409353
Ig 2782..2859 CDD:472250
Ig strand B 2789..2793 CDD:409353
Ig strand C 2802..2806 CDD:409353
Ig strand E 2827..2831 CDD:409353
Ig strand F 2839..2844 CDD:409353
Ig strand G 2852..2855 CDD:409353
I-set 2876..2954 CDD:400151
Ig strand B 2884..2888 CDD:409562
Ig strand C 2897..2901 CDD:409562
Ig strand E 2920..2924 CDD:409562
Ig strand F 2934..2939 CDD:409562
Ig strand G 2947..2950 CDD:409562
I-set 2966..3046 CDD:400151
Ig strand B 2976..2980 CDD:409353
Ig strand C 2989..2993 CDD:409353
Ig strand E 3012..3016 CDD:409353
Ig strand F 3026..3031 CDD:409353
I-set 3050..3141 CDD:400151 10/35 (29%)
Ig strand B 3071..3075 CDD:409353
Ig strand C 3084..3088 CDD:409353
Ig strand E 3107..3111 CDD:409353 0/3 (0%)
Ig strand F 3121..3126 CDD:409353 1/4 (25%)
Ig strand G 3134..3137 CDD:409353 0/2 (0%)
Ig 3145..3233 CDD:472250 25/97 (26%)
Ig strand B 3163..3167 CDD:409353 3/3 (100%)
Ig strand C 3176..3180 CDD:409353 0/3 (0%)
Ig strand E 3199..3203 CDD:409353 1/3 (33%)
Ig strand F 3213..3218 CDD:409353 2/4 (50%)
Ig_3 3236..3315 CDD:464046 25/83 (30%)
Ig 3347..3422 CDD:472250 20/76 (26%)
Ig strand B 3352..3356 CDD:409353 0/3 (0%)
Ig strand C 3365..3369 CDD:409353 2/3 (67%)
Ig strand E 3389..3392 CDD:409353 1/2 (50%)
Ig strand F 3402..3407 CDD:409353 1/4 (25%)
Ig 3436..3511 CDD:472250 13/74 (18%)
Ig strand B 3445..3449 CDD:409544 0/3 (0%)
Ig strand C 3458..3462 CDD:409544 0/3 (0%)
Ig strand E 3476..3481 CDD:409544 0/4 (0%)
Ig strand F 3491..3496 CDD:409544 1/4 (25%)
Ig strand G 3504..3507 CDD:409544 0/2 (0%)
Ig 3529..3602 CDD:472250 8/72 (11%)
Ig strand B 3534..3538 CDD:409353 1/3 (33%)
Ig strand C 3547..3551 CDD:409353 0/3 (0%)
Ig strand E 3568..3572 CDD:409353 0/3 (0%)
Ig strand F 3582..3587 CDD:409353 0/4 (0%)
Ig 3614..3695 CDD:472250 4/18 (22%)
Ig strand B 3625..3629 CDD:409394 1/3 (33%)
Ig strand C 3638..3642 CDD:409394
Ig strand E 3661..3665 CDD:409394
Ig strand F 3675..3680 CDD:409394
Ig strand G 3688..3691 CDD:409394
I-set 3699..3786 CDD:400151
Ig strand B 3716..3720 CDD:409353
Ig strand C 3729..3733 CDD:409353
Ig strand E 3753..3756 CDD:409353
Ig strand F 3766..3771 CDD:409353
Ig strand G 3779..3782 CDD:409353
Ig 3790..3881 CDD:472250
Ig strand B 3807..3811 CDD:409490
Ig strand C 3820..3824 CDD:409490
Ig strand E 3845..3849 CDD:409490
Ig strand F 3859..3864 CDD:409490
Ig strand G 3873..3877 CDD:409490
Ig 3900..3970 CDD:472250
Ig strand B 3900..3904 CDD:409544
Ig strand C 3913..3917 CDD:409544
Ig strand E 3936..3940 CDD:409544
Ig strand F 3950..3955 CDD:409544
Ig strand G 3963..3966 CDD:409544
I-set 3974..4060 CDD:400151
Ig strand B 3991..3995 CDD:409560
Ig strand C 4004..4008 CDD:409560
Ig strand E 4026..4030 CDD:409560
Ig strand F 4040..4045 CDD:409560
Ig 4064..4151 CDD:472250
Ig strand B 4081..4085 CDD:409353
Ig strand C 4094..4098 CDD:409353
Ig strand E 4117..4121 CDD:409353
Ig strand F 4131..4136 CDD:409353
Ig strand G 4144..4147 CDD:409353
I-set 4155..4240 CDD:400151
Ig strand C 4185..4189 CDD:409353
Ig strand E 4206..4210 CDD:409353
Ig strand F 4220..4225 CDD:409353
Ig strand G 4234..4237 CDD:409353
Ig_3 4244..4318 CDD:464046
Ig 4336..4421 CDD:472250
Ig strand B 4352..4356 CDD:409544
Ig strand C 4365..4369 CDD:409544
Ig strand E 4387..4391 CDD:409544
Ig strand F 4401..4406 CDD:409544
Ig strand G 4414..4417 CDD:409544
nidG2 4423..4639 CDD:469646
FXa_inhibition 4664..4699 CDD:464251
EGF_CA 4701..4745 CDD:214542
EGF_CA 4746..4783 CDD:214542
EGF_CA 4789..4829 CDD:214542
EGF_CA 4896..4935 CDD:214542
EGF_CA 4936..4974 CDD:214542
Blue background indicates that the domain is not in the aligned region.

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