DRSC/TRiP Functional Genomics Resources

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Protein Alignment klg and Negr1

DIOPT Version :9

Sequence 1:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster
Sequence 2:XP_038958934.1 Gene:Negr1 / 59318 RGDID:708416 Length:362 Species:Rattus norvegicus


Alignment Length:306 Identity:91/306 - (29%)
Similarity:143/306 - (46%) Gaps:22/306 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 SNVQQSAVAASTLTATLPRFLSRGHTYRAV------VGDTLVLPCQVENLGNFVLLWRRGTNVLT 142
            ||...:||..| |.:.||...|....:.||      .|||.||.|.:|: |.....|...::::.
  Rat    11 SNQWLAAVLLS-LCSCLPAGQSVDFPWAAVDNMLVRKGDTAVLRCYLED-GASKGAWLNRSSIIF 73

  Fly   143 ASNIMVTRDERVRLID----GYNLEISDLEPQDAGDYVCQISDK--INRDQVHTVEILVPPSVRA 201
            |.....:.|.||.:..    .|:|:|.:::..|.|.|.|.:..:  ....||| :.:.|||.:..
  Rat    74 AGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVH-LTVQVPPKIYD 137

  Fly   202 IPTSGQLQARKGGPITLECKGSGNPVPSIYWTKKSGANKSTARIGDGPILTLEKLERQQAGVYQC 266
            |  |..:...:|..:||.|..:|.|.|:|.|...|.:.|.   ..:|..|.:..:.|.|||.|:|
  Rat   138 I--SNDMTINEGTNVTLTCLATGKPEPAISWRHISPSAKP---FENGQYLDIYGITRDQAGEYEC 197

  Fly   267 TADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQST 331
            :|:|.|..|....:|:.|.:.|.||..||...: .|....:.|.....|.....||:....:.:.
  Rat   198 SAENDVSFPDVKKVRVVVNFAPTIQEIKSGTVT-PGRSGLIRCEGAGVPPPAFEWYKGEKRLFNG 261

  Fly   332 DRRIMATR-ANRHMLTIRHIQQEDFGNYSCVADNSLGRSRKYMELS 376
            .:.|:... :.|.:||:.::.||.||||:|||.|.||.:...:.|:
  Rat   262 QQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLN 307

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klgNP_524454.2 DUF1370 63..>124 CDD:284518 17/45 (38%)
IG_like 109..195 CDD:214653 25/97 (26%)
Ig 118..191 CDD:143165 20/78 (26%)
IG_like 205..274 CDD:214653 23/68 (34%)
IGc2 213..273 CDD:197706 21/59 (36%)
IGc2 301..367 CDD:197706 19/66 (29%)
FN3 392..486 CDD:238020
Negr1XP_038958934.1 FR1 38..55 CDD:409353 7/16 (44%)
Ig strand A' 40..46 CDD:409353 0/5 (0%)
IG_like 41..129 CDD:214653 23/89 (26%)
Ig strand B 48..56 CDD:409353 5/7 (71%)
CDR1 56..60 CDD:409353 1/4 (25%)
FR2 61..68 CDD:409353 1/6 (17%)
Ig strand C 61..67 CDD:409353 1/5 (20%)
CDR2 69..79 CDD:409353 1/9 (11%)
Ig strand C' 71..74 CDD:409353 0/2 (0%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 10/34 (29%)
Ig strand D 84..91 CDD:409353 2/6 (33%)
Ig strand E 94..100 CDD:409353 2/5 (40%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 0/3 (0%)
Ig strand G 120..129 CDD:409353 3/9 (33%)
FR4 122..129 CDD:409353 3/7 (43%)
Ig strand A' 139..144 CDD:409353 1/4 (25%)
IGc2 146..204 CDD:197706 21/60 (35%)
Ig strand B 150..157 CDD:409353 3/6 (50%)
Ig strand C 163..168 CDD:409353 2/4 (50%)
Ig strand C' 170..172 CDD:409353 1/1 (100%)
Ig strand E 180..186 CDD:409353 1/5 (20%)
Ig strand F 193..200 CDD:409353 3/6 (50%)
Ig strand G 207..215 CDD:409353 1/7 (14%)
Ig_3 219..295 CDD:404760 23/76 (30%)
putative Ig strand A 219..225 CDD:409353 3/5 (60%)
Ig strand B 235..239 CDD:409353 0/3 (0%)
Ig strand C 248..252 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 1/3 (33%)
Ig strand F 288..293 CDD:409353 3/4 (75%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166337202
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X97
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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