DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and iglon5

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001017775.2	Gene:	iglon5 / 550472	ZFINID:	ZDB-GENE-050417-297	Length:	332	Species:	Danio rerio

Alignment Length:	273	Identity:	77/273 - (28%)
Similarity:	128/273 - (46%)	Gaps:	16/273 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 GDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDG----YNLEISDLEPQDAGDY 175
            |:::||.|:::..... ..|...:|:|.......:.|.||.|.:.    :::.|..:...|.|.|
Zfish    41 GESVVLRCKIDEEVTH-KAWLNRSNILFTGTDKWSLDSRVSLENNNNSDFSIRIERVMVADEGPY 104

  Fly   176 VCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTK-KSGAN 239
            .|....: |:.:...|.::|....|.:..|......:|..:.|.|...|.|.|:|.|.. |.|.
Zfish   105 TCSFQAR-NKPRTAHVYLIVQVPARIVNISQDKSVNEGEDVNLFCLAVGRPEPTITWKDFKYGL- 167

  Fly   240 KSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFE 304
                 :.:|..|.:.:::|.||..::|..:|||..|.|..:::.|.|||.|...|: :.:..|..
Zfish   168 -----LNEGEFLEITEIKRHQAEDFECITNNGVAPPDTRKVKVTVNYPPIITDVKN-MPAQVGKT 226

  Fly   305 AKLVCIVFADPVATVSWYQNS-FPIQSTDRRIMATRANRHMLTIRHIQQEDFGNYSCVADNSLGR 368
            |.|.|...|.|.|:..||::. .|::|.:...:.....|.:|...::.::.||||:|.|.|.||.
Zfish   227 AILRCEAMAVPTASFEWYRDDRRPVESDNTLKIKNEKTRSLLLFTNVTEKHFGNYTCFASNRLGA 291

  Fly   369 SRKYMELSGRPGA 381
            |...| |..||||
Zfish   292 SNASM-LLFRPGA 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	4/8 (50%)
		IG_like	109..195	CDD:214653	18/83 (22%)
		Ig	118..191	CDD:143165	16/76 (21%)
		IG_like	205..274	CDD:214653	20/69 (29%)
		IGc2	213..273	CDD:197706	18/60 (30%)
		IGc2	301..367	CDD:197706	20/66 (30%)
		FN3	392..486	CDD:238020
iglon5	NP_001017775.2	IG_like	33..123	CDD:214653	18/83 (22%)
		Ig	35..123	CDD:299845	18/83 (22%)
		Ig	125..>183	CDD:299845	15/63 (24%)
		I-set	128..207	CDD:254352	23/84 (27%)
		IG_like	217..298	CDD:214653	25/82 (30%)
		ig	223..296	CDD:278476	23/72 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4772
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.890