DRSC/TRiP Functional Genomics Resources

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Protein Alignment klg and NTM

DIOPT Version :9

Sequence 1:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:286 Identity:81/286 - (28%)
Similarity:135/286 - (47%) Gaps:31/286 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 ATLPRFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDG--- 159
            ||.|:.:. ..|.|.  |::..|.|.::|....| .|...:.:|.|.|.....|.||.|:..   
Human    36 ATFPKAMD-NVTVRQ--GESATLRCTIDNRVTRV-AWLNRSTILYAGNDKWCLDPRVVLLSNTQT 96

  Fly   160 -YNLEISDLEPQDAGDYVCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGS 223
             |::||.:::..|.|.|.|.:... |..:...|.::|..|.:.:..|..:...:|..|:|.|..:
Human    97 QYSIEIQNVDVYDEGPYTCSVQTD-NHPKTSRVHLIVQVSPKIVEISSDISINEGNNISLTCIAT 160

  Fly   224 GNPVPSIYWTKKSGANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPP 288
            |.|.|::.|...|  .|:...:.:...|.::.:.|:|:|.|:|:|.|.|..||...:::.|.|||
Human   161 GRPEPTVTWRHIS--PKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPP 223

  Fly   289 DIQVEKSWIHSG--EGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMATR-----ANRHMLT 346
            .|...|.   :|  .|.:..|.|...|.|.|...||::       |:|::..:     .||..|:
Human   224 YISEAKG---TGVPVGQKGTLQCEASAVPSAEFQWYKD-------DKRLIEGKKGVKVENRPFLS 278

  Fly   347 ---IRHIQQEDFGNYSCVADNSLGRS 369
               ..::.:.|:|||:|||.|.||.:
Human   279 KLIFFNVSEHDYGNYTCVASNKLGHT 304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klgNP_524454.2 DUF1370 63..>124 CDD:284518 8/25 (32%)
IG_like 109..195 CDD:214653 24/89 (27%)
Ig 118..191 CDD:143165 20/76 (26%)
IG_like 205..274 CDD:214653 20/68 (29%)
IGc2 213..273 CDD:197706 18/59 (31%)
IGc2 301..367 CDD:197706 21/73 (29%)
FN3 392..486 CDD:238020
NTMNP_001338930.1 Ig 44..132 CDD:416386 24/91 (26%)
Ig strand A' 44..49 CDD:409353 1/4 (25%)
Ig strand B 51..59 CDD:409353 2/7 (29%)
CDR1 59..63 CDD:409353 1/3 (33%)
FR2 64..70 CDD:409353 2/6 (33%)
Ig strand C 64..70 CDD:409353 2/6 (33%)
CDR2 71..83 CDD:409353 3/11 (27%)
Ig strand C' 72..76 CDD:409353 0/3 (0%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 11/33 (33%)
Ig strand D 87..94 CDD:409353 3/6 (50%)
Ig strand E 97..103 CDD:409353 2/5 (40%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 1/4 (25%)
Ig strand G 123..132 CDD:409353 1/8 (13%)
FR4 125..132 CDD:409353 1/6 (17%)
Ig_3 136..205 CDD:404760 18/70 (26%)
Ig strand A' 142..147 CDD:409353 1/4 (25%)
Ig strand B 153..160 CDD:409353 3/6 (50%)
Ig strand C 166..171 CDD:409353 1/4 (25%)
Ig strand D 177..180 CDD:409353 0/2 (0%)
Ig strand E 184..190 CDD:409353 1/5 (20%)
Ig strand F 197..204 CDD:409353 3/6 (50%)
Ig strand G 211..219 CDD:409353 1/7 (14%)
Ig_3 222..299 CDD:404760 25/86 (29%)
putative Ig strand A 223..229 CDD:409353 2/5 (40%)
Ig strand B 239..243 CDD:409353 1/3 (33%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 0/3 (0%)
Ig strand F 292..297 CDD:409353 3/4 (75%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143468
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.740

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