DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and opcml

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001005580.1	Gene:	opcml / 449538	ZFINID:	ZDB-GENE-040927-3	Length:	342	Species:	Danio rerio

Alignment Length:	354	Identity:	97/354 - (27%)
Similarity:	156/354 - (44%)	Gaps:	64/354 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LQMNCPILIVISLGWLLHAHAGSGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSR 106
            ||..|  |:|::|..|         |.|.|.:..|..:|....|:
Zfish     9 LQWKC--LVVVALRLL---------FLVPAGVPARSGDSYLKDNI-------------------- 42

  Fly   107 GHTYRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRL----IDGYNLEISDL 167
              |.|.  ||:.||.|.::|..:.| .|...|.:|...|...:.|.||.|    ::.|:::|.::
Zfish    43 --TVRQ--GDSAVLKCSMDNKVSRV-AWLNRTTILFTGNEKWSLDPRVVLLNTAVNEYSIKILNV 102

  Fly   168 EPQDAGDYVCQI--SDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSI 230
            ...|.|.|||.|  :.|....:||.: :.||  .|.:..|..:...:|..::|.|...|.|.|||
Zfish   103 NLYDEGPYVCSILTNKKPESTKVHLI-VQVP--ARIVNVSTDVSVNEGSNVSLMCLAIGRPEPSI 164

  Fly   231 YWTKKSGANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKS 295
            .|  |..::|....:.:|..:.:..:.:..:|.|.|...|.:..|....:::.|.|||.|...:|
Zfish   165 LW--KFRSSKGNRIVTEGEYVEMTGITKDMSGSYDCITSNDISPPDVRTVQVTVNYPPVISRARS 227

  Fly   296 WIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIM--------ATRANRHMLTIRHIQQ 352
             ..:..|.:..|.|...|.|:|...|::.       :|||:        ..:..:.|||..::.:
Zfish   228 -TGTAVGQKGVLWCEASAVPLADFQWFKG-------ERRILNGFNGVKIENKGKQSMLTFFNVSE 284

  Fly   353 EDFGNYSCVADNSLGRSRKYMELSGRPGA 381
            ||:|||:|||.|:||.:...:.|.| |||
Zfish   285 EDYGNYTCVAINTLGITNASIILYG-PGA 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	13/60 (22%)
		IG_like	109..195	CDD:214653	28/91 (31%)
		Ig	118..191	CDD:143165	24/78 (31%)
		IG_like	205..274	CDD:214653	17/68 (25%)
		IGc2	213..273	CDD:197706	16/59 (27%)
		IGc2	301..367	CDD:197706	22/73 (30%)
		FN3	392..486	CDD:238020
opcml	NP_001005580.1	Ig	41..129	CDD:299845	29/113 (26%)
		IG_like	41..129	CDD:214653	29/113 (26%)
		IG_like	139..216	CDD:214653	18/78 (23%)
		IGc2	146..202	CDD:197706	15/57 (26%)
		I-set	219..307	CDD:254352	28/95 (29%)
		ig	223..307	CDD:278476	25/91 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.740