DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and CG7166

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001262181.1	Gene:	CG7166 / 40401	FlyBaseID:	FBgn0037107	Length:	467	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	223/396 - (56%)
Similarity:	301/396 - (76%)	Gaps:	6/396 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 TLPRFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLE 163
            |.|:||||||.|:.:||:|:.|||:|:|||:||||||:|::||||.::.:|||:|.:::..|||:
  Fly    37 TAPKFLSRGHLYKVIVGETIELPCKVQNLGSFVLLWRKGSSVLTAGHLKITRDQRFKIVGDYNLQ 101

  Fly   164 ISDLEPQDAGDYVCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVP 228
            |:.::.||||||:||:.|:.||||||||||||||::||:|.:||:.||||..:|||||.||||||
  Fly   102 INGVKTQDAGDYICQLGDQENRDQVHTVEILVPPTLRALPHNGQVTARKGSTVTLECKASGNPVP 166

  Fly   229 SIYWTKKSGANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVE 293
            :|:|.||...:..| .:.|...|.||.::|..||.|||:|||||.|.|::|::|.:|.||:|.||
  Fly   167 TIFWFKKDVFSGPT-HLSDSSTLILENVDRHHAGTYQCSADNGVKDRVSMDIQLTILSPPEITVE 230

  Fly   294 KSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMATRANRHMLTIRHIQQEDFGNY 358
            |||:|:.||::.:|||||..|..:.:.||||||.:.:||||.|..|.:|:.|.||:.|..|||||
  Fly   231 KSWVHASEGYDVELVCIVHGDVNSEMLWYQNSFLLDATDRRSMYPRDDRYSLIIRNFQPTDFGNY 295

  Fly   359 SCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYRRVQMNET 423
            ||||||:|||::||:|:|||||.|:|.||......|.|||||.|:|.|||:|::|||||:.||||
  Fly   296 SCVADNALGRTKKYIEVSGRPGPADFISPALSGFLDHYNLTWTIESIPPLDEIKLLYRRLLMNET 360

  Fly   424 YQQPGRWHDFILTPEHRPASEPLTH-IMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSDIFQFVVA 487
            ||.||:||::.:.|  .|.....:| :|||.:|||.....|||||||||:|||||:|||.||.
  Fly   361 YQHPGKWHEYHIKP--TPIRTDGSHFLMSYLVKNLEHNAVYEAIVQAKNKYGWNEISDIHQFY-- 421

  Fly   488 TNSQDI 493
            |.:.|:
  Fly   422 TRNHDL 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	15/24 (63%)
		IG_like	109..195	CDD:214653	49/85 (58%)
		Ig	118..191	CDD:143165	41/72 (57%)
		IG_like	205..274	CDD:214653	37/68 (54%)
		IGc2	213..273	CDD:197706	31/59 (53%)
		IGc2	301..367	CDD:197706	36/65 (55%)
		FN3	392..486	CDD:238020	55/94 (59%)
CG7166	NP_001262181.1	IG_like	50..133	CDD:214653	48/82 (59%)
		Ig	56..116	CDD:143165	32/59 (54%)
		IG_like	144..221	CDD:214653	41/77 (53%)
		IGc2	151..209	CDD:197706	30/58 (52%)
		IG_like	232..313	CDD:214653	45/80 (56%)
		Ig	242..311	CDD:143165	39/68 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I6839
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	118	1.000	Inparanoid score	I4772
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D27331at7147
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14108
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45080
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	8	7.970