DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and CG13506

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001286718.1	Gene:	CG13506 / 37556	FlyBaseID:	FBgn0034723	Length:	503	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	105/457 - (22%)
Similarity:	190/457 - (41%)	Gaps:	76/457 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 GDTLVLPCQVEN--LGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLEISDLEPQDAGDYVC 177
            ||.::|.|...|  |.|.|:.::....:....|.:   .:||:.:...::.:.::.|:|:.||.|
  Fly    84 GDDVILNCDARNFQLSNAVVWYKNRIIIANGQNPI---SQRVQCMLNNSILLRNVSPEDSDDYYC 145

  Fly   178 QISDKINRDQVHT-------VEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTKK 235
            :|..:  |.:.||       :.||...  |.|....| ..|:|....|||:.......:|.|:..
  Fly   146 EILPQ--RVRQHTALRVGARLSILCDD--RDITDRSQ-TFRQGDHHKLECRTYLPDNATIKWSFN 205

  Fly   236 SGANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSG 300
            ....:.::......::.|:.::.:.||.|||.||:|...|....:.:||.|.|.:...:..:::.
  Fly   206 DLNGQPSSVDNQNGVIILDNVDEKNAGDYQCLADDGSRHPPHGTVHIDVQYSPIVSTHRHNVNTE 270

  Fly   301 EGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMATRA----NRHMLTIRHIQQEDFGNYSCV 361
            :|..|:|.|...|.|:....:.::...:|.:|:..:....    ||..|.:|.:...|.|.|.|.
  Fly   271 KGATAELYCNYRAKPIGRSYFIKDGKTLQLSDKYSLKDSVHNDHNRTTLIVREVTDSDLGEYLCQ 335

  Fly   362 ADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPD------SYNLTWKIDSYPPLEEVRLLYRRVQM 420
            .:|::|.:...:.:|        |:|:..:..|      ...|.|.:.|:..|.|..|.|   |:
  Fly   336 VENAIGSNEVKVHVS--------YNPETPQFEDMTVEGNKVTLHWLVRSHQLLSEAMLDY---QL 389

  Fly   421 NETYQQPGRWHDFILTPEHRPASE----PLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSDI 481
            ..:|    .|....:...||..:.    .:||.:..:      .|.:.|.|:.||..||:..|:.
  Fly   390 TGSY----TWSTVQVLETHRHNNTDNIWKITHQLELS------RGVWHARVKTKNTKGWSHFSND 444

  Fly   482 FQFVVATNSQDIGPEDAEVVASSK----------------SRSNSASIGSLPGSTVLHTALLLAL 530
            ..|.:        |||:||....:                |:..::|:..|....:|..||||.:
  Fly   445 HVFEI--------PEDSEVDKDEEVELPPDEIVQAGIMPMSKGAASSMQRLNVGVILLAALLLRV 501

  Fly   531 AL 532
            .|
  Fly   502 RL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	4/8 (50%)
		IG_like	109..195	CDD:214653	21/88 (24%)
		Ig	118..191	CDD:143165	18/81 (22%)
		IG_like	205..274	CDD:214653	17/68 (25%)
		IGc2	213..273	CDD:197706	15/59 (25%)
		IGc2	301..367	CDD:197706	17/69 (25%)
		FN3	392..486	CDD:238020	24/103 (23%)
CG13506	NP_001286718.1	IG_like	79..146	CDD:214653	15/64 (23%)
		IGc2	83..146	CDD:197706	15/64 (23%)
		IG_like	176..254	CDD:214653	18/78 (23%)
		Ig	176..239	CDD:299845	14/63 (22%)
		I-set	258..349	CDD:254352	19/90 (21%)
		Ig	275..348	CDD:143165	17/72 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464483
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45080
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840