DRSC/TRiP Functional Genomics Resources

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Protein Alignment klg and Lac

DIOPT Version :9

Sequence 1:NP_524454.2 Gene:klg / 42707 FlyBaseID:FBgn0017590 Length:545 Species:Drosophila melanogaster
Sequence 2:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster


Alignment Length:294 Identity:70/294 - (23%)
Similarity:126/294 - (42%) Gaps:49/294 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 VGDTLVLPCQVENLGNFVLLWRRGTN---VLTASNIMVTRDERVRL-----IDGYNLEISDLEPQ 170
            :|.|:...|.|:....:.:|:.:..:   .|:..:.:|.:|.|..|     ...|.|:|.|::..
  Fly    42 IGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQET 106

  Fly   171 DAGDYVCQISDKINRDQVHTVEILVPPSVRAIP-----TSGQLQARKGGPITLECKGSGNPVPSI 230
            |||.|.||:.    ...||.|...|..|||..|     ::..:.|.:|..:.:||..||.|.|:|
  Fly   107 DAGTYTCQVV----ISTVHKVSAEVKLSV
RRPPVISDNSTQSVVASEGSEVQMECYASGYPTPTI 167

  Fly   231 YWTKKSGA---NKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQV 292
            .|.:::.|   ..|...:|:  .|.::.::::..|.|.|.|||||......::.::|.:.|.|.|
  Fly   168 TWRRENNAILPTDSATYVGN--TLRIKSVKKEDRGTYYCVADNGVSKGDRRNINVEVEFAPVITV 230

  Fly   293 EKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMATRANRHMLTIRH-------- 349
            .:..:.....::..|.|.:.|.|...:.|.::...:           ||....:|.|        
  Fly   231 PRPRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQL-----------ANNQHYSISHFATADEYT 284

  Fly   350 --------IQQEDFGNYSCVADNSLGRSRKYMEL 375
                    :::..:|:|.|.|.|..|.:...:.|
  Fly   285 DSTLRVITVEKRQYGDYVCKATNRFGEAEARVNL 318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
klgNP_524454.2 DUF1370 63..>124 CDD:284518 3/9 (33%)
IG_like 109..195 CDD:214653 23/88 (26%)
Ig 118..191 CDD:143165 20/80 (25%)
IG_like 205..274 CDD:214653 22/71 (31%)
IGc2 213..273 CDD:197706 20/62 (32%)
IGc2 301..367 CDD:197706 14/81 (17%)
FN3 392..486 CDD:238020
LacNP_523713.2 IG_like 36..131 CDD:214653 24/92 (26%)
FR1 37..50 CDD:409353 2/7 (29%)
Ig strand A' 37..42 CDD:409353 70/294 (24%)
Ig strand B 44..51 CDD:409353 1/6 (17%)
CDR1 51..59 CDD:409353 1/7 (14%)
Ig strand C 59..63 CDD:409353 1/3 (33%)
FR2 60..63 CDD:409353 1/2 (50%)
CDR2 67..81 CDD:409353 2/13 (15%)
Ig strand C' 68..72 CDD:409353 0/3 (0%)
Ig strand C' 79..81 CDD:409353 1/1 (100%)
FR3 84..115 CDD:409353 11/30 (37%)
Ig strand D 84..90 CDD:409353 2/5 (40%)
Ig strand E 94..102 CDD:409353 3/7 (43%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 2/11 (18%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 19/75 (25%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 1/3 (33%)
Ig strand E 187..191 CDD:409353 1/5 (20%)
Ig strand F 201..206 CDD:409353 2/4 (50%)
Ig strand G 215..218 CDD:409353 0/2 (0%)
Ig 227..318 CDD:416386 17/101 (17%)
Ig strand C 256..260 CDD:409353 0/3 (0%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45442826
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X97
43.740

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