DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_954545.1	Gene:	Fgfrl1 / 360903	RGDID:	735156	Length:	529	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	117/596 - (19%)
Similarity:	198/596 - (33%)	Gaps:	207/596 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PILIVISLGWLLHAHAGSGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSRGHTYR 111
            |.|:::.||.|..|.|..|             ..|....|             :||.::|
  Rat     5 PALLLLLLGALPSAEAARG-------------PPRMADKV-------------VPRQVAR----- 38

  Fly   112 AVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYN--------LEISDLE 168
              :|.|:.|.|.||.....:.:|              |:|.|. :..|::        |::.::|
  Rat    39 --LGRTVRLQCPVEGDPPPLTMW--------------TKDGRT-IHSGWSRFRVLPQGLKVKEVE 86

  Fly   169 PQDAGDYVCQISDKINRDQVHTVEILV----PPSVRAIP--TSG-------QLQARK-------- 212
            .:|||.|||:.::......|:...|::    |......|  :||       |..||.
  Rat    87 AEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKENPGPGGSSGGQEDPVSQQWARPRFTQPSKM 151

  Fly   213 ---------GGPITLECKGSGNPVPSIYWTKKSGANKSTARIGDGP------ILTLEKLERQQAG 262
                     |..:.|:|..||:|.|.|.|.|.   :::..|:....      .|:|:.|:.:.:|
  Rat   152 RRRVIARPVGSSVRLKCVASGHPRPDIMWMKD---DQTLTRLEASEHRKKKWTLSLKNLKPEDSG 213

  Fly   263 VYQCTADNGVGDPVTVDMRLDVL------------YPPDIQVEKSWIHSGEGFEAKLVCIVFADP 315
            .|.|...|..| .:....::||:            :|.:..|:       .|......|.|.:|.
  Rat   214 KYTCRVSNRAG-AINATYKVDVIQRTRSKPVLTGTHPVNTTVD-------FGGTTSFQCKVRSDV 270

  Fly   316 VATVSWYQNSFPIQSTDRRIMATRANRH-----------------------------MLTIRHIQ 351
            ...:.|.          :|:......||                             .|.|...:
  Rat   271 KPVIQWL----------KRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLLISRAR 325

  Fly   352 QEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYR 416
            |:|.|.|.|:..|::|.|.:...|:..|.... ..|....|..:.:|.|.:....|...|.:|..
  Rat   326 QDDAGMYICLGANTMGYSFRSAFLTVLPDPKP-PGPPVAHSSSTTSLPWPVVIGIPAGAVFILGT 389

  Fly   417 -RVQMNETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSD 480
             .:.:.:|.::|......:..|.|||                 ||       .::.|.|..::..
  Rat   390 VLLWLCQTKKKPCAPASTLPVPGHRP-----------------PG-------TSRERSGDKDLPS 430

  Fly   481 IF-------------QFVVATNSQDIGPE-------DAEVVASSKSRSNSASIGSLPGS------ 519
            :.             |.::|..| ..||:       |......:.:.:::.|.|....|
  Rat   431 LAVGICEEHGSTMAPQHILAPGS-TAGPKLYPKLYTDVHTHTHTHTCTHTLSCGGQGSSAPACPL 494

  Fly   520 TVLHTALLLAL 530
            :||:||.|.||
  Rat   495 SVLNTANLQAL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	10/60 (17%)
		IG_like	109..195	CDD:214653	21/93 (23%)
		Ig	118..191	CDD:143165	18/80 (23%)
		IG_like	205..274	CDD:214653	23/98 (23%)
		IGc2	213..273	CDD:197706	18/65 (28%)
		IGc2	301..367	CDD:197706	16/94 (17%)
		FN3	392..486	CDD:238020	17/107 (16%)
Fgfrl1	NP_954545.1	I-set	29..112	CDD:400151	24/117 (21%)
		Ig strand A'	35..38	CDD:409353	0/2 (0%)
		Ig strand B	41..50	CDD:409353	3/8 (38%)
		Ig strand C	56..61	CDD:409353	1/18 (6%)
		Ig strand C'	64..67	CDD:409353	1/3 (33%)
		Ig strand D	72..77	CDD:409353	0/4 (0%)
		Ig strand E	78..84	CDD:409353	1/5 (20%)
		Ig strand F	91..99	CDD:409353	4/7 (57%)
		Ig strand G	102..112	CDD:409353	1/9 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..152		7/34 (21%)
		IgI_2_FGFRL1-like	143..234	CDD:409442	19/94 (20%)
		Ig strand B	164..168	CDD:409442	1/3 (33%)
		Ig strand C	177..181	CDD:409442	1/3 (33%)
		Ig strand E	200..204	CDD:409442	1/3 (33%)
		Ig strand F	214..219	CDD:409442	2/4 (50%)
		Ig strand G	227..230	CDD:409442	0/2 (0%)
		Ig	242..350	CDD:416386	20/124 (16%)
		Ig strand A	242..245	CDD:409353	0/2 (0%)
		Ig strand A'	249..253	CDD:409353	1/3 (33%)
		Ig strand B	261..268	CDD:409353	2/6 (33%)
		Ig strand C	272..279	CDD:409353	1/16 (6%)
		Ig strand D	304..309	CDD:409353	0/4 (0%)
		Ig strand E	317..322	CDD:409353	1/4 (25%)
		Ig strand F	330..338	CDD:409353	3/7 (43%)
		Ig strand G	341..349	CDD:409353	2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000