DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and DIP-eta

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	99/348 - (28%)
Similarity:	157/348 - (45%)	Gaps:	27/348 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PRFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRR--GTNVLTASNIMVTRDERVRLIDG---- 159
            |:|.|......|.||....|.|.|::||.:.:.|.|  ...:||..|.::|:::|:.:.:.
  Fly    43 PKFSSPIVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTILTIQNHVITKNQRIGIANSEHKT 107

  Fly   160 YNLEISDLEPQDAGDYVCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSG 224
            :.:.|.|::..|.|.|:|||:....:.|:..::::|||.:...|||..:..|:|..:||:|..:|
  Fly   108 WTMRIKDIKESDKGWYMCQINTDPMKSQMGYLDVVVPPDILDYPTSTDMVVREGSNVTLKCAATG 172

  Fly   225 NPVPSIYWTKKSG-----ANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDV 284
            :|.|:|.|.::||     |........:|..|.:..:.|...|.|.|.|.|||...|:..:.|.|
  Fly   173 SPEPTITWRRESGVPIELATGEEVMSIEGTDLVIPNVRRHHMGAYLCIASNGVPPSVSKRITLVV 237

  Fly   285 LYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMAT------RANRH 343
            .:||.|.|:...|.:.||....|.|...|.|.:...|.:....|.....:..|.      ..|..
  Fly   238 HFPPMITVQNQLIGAVEGKGVTLDCESEAYPKSINYWTRERGEIVPPGGKYSANVTEIGGYRNSM 302

  Fly   344 MLTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPL 408
            .|.|..:.|.:||:|.|||.||||.:...::|...|..|..|...:.........|...:|:.|
  Fly   303 RLHINPLTQAEFGSYRCVAKNSLGDTDGTIKLYRIPPNAVNYVENFEARHKGKKRTKSSESHHP- 366

  Fly   409 EEVRLLYRRVQ--MNETYQQPGR 429
                   .|.|  ..|..:.||:
  Fly   367 -------ARAQEHSGEDMENPGK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	8/22 (36%)
		IG_like	109..195	CDD:214653	24/91 (26%)
		Ig	118..191	CDD:143165	21/78 (27%)
		IG_like	205..274	CDD:214653	24/73 (33%)
		IGc2	213..273	CDD:197706	21/64 (33%)
		IGc2	301..367	CDD:197706	21/71 (30%)
		FN3	392..486	CDD:238020	8/40 (20%)
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	24/89 (27%)
		IG_like	51..137	CDD:214653	24/85 (28%)
		IG_like	153..237	CDD:214653	26/83 (31%)
		Ig	161..224	CDD:299845	19/62 (31%)
		IG_like	252..335	CDD:214653	23/82 (28%)
		Ig	258..333	CDD:143165	21/74 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	4	3.740