DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and CG33543

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001014458.3	Gene:	CG33543 / 3346207	FlyBaseID:	FBgn0053543	Length:	468	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	88/422 - (20%)
Similarity:	159/422 - (37%)	Gaps:	84/422 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 VGDTLVLPCQVENLGNFVLLWR--RG-TNVLTASNIMVTRDERVRLIDGYNLEISDLEPQDAGDY 175
            |.::.::.||... .:....||  || |...|...:.:.:.....|.    |....:..:|.|::
  Fly    61 VNESFIIFCQTVQ-KDIDTKWRDPRGQTRENTKGRVHIEKKTTGLLA----LVFEHIALEDRGNW 120

  Fly   176 VCQISD--------KINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYW 232
            .|:::.        .:.|:.:.:.|:||...:....|......|:|....:.|...|.|.|.:.|
  Fly   121 TCEVNGNRNGNRNVNVEREFLASFELLVNQKISFGKTEQVQSVREGRDAMVNCFVEGMPAPEVSW 185

  Fly   233 TKKSGANKSTA------RIGDGPILTLEKLERQQAGVYQCTA--------DNGVGDPVTVDMRLD 283
            . .:|...:|.      |:.:|  |.:..:.:..||.|.|.|        |:   |.:|:.:|
  Fly   186 L-YNGEYINTVNSTKHNRLSNG--LYIRNVSQADAGEYTCRAMRITPTFSDS---DQITILLR-- 242

  Fly   284 VLYPPDIQVEKSWI--------HSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRI-MATR 339
                  ||.:..|.        ::..|....|.|....:|..:.:|..|:..|...:.|| :|..
  Fly   243 ------IQHKPHWFFNETLPVQYAYVGGAVNLSCDAMGEPPPSFTWLHNNKGIVGFNHRIFVADY 301

  Fly   340 ANRHMLTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDS 404
            .....|.:::..|  ||:|.|...|.||...:.::|  |||.... .|:..:....|...:::|.
  Fly   302 GATLQLQMKNASQ--FGDYKCKVANPLGMLERVIKL--RPGPKPL-GPRRFQLKKLYTNGFELDI 361

  Fly   405 YPP-----LEEVRLL-YRRVQMNETYQQ--PGRW-----HDFIL-TPEHRPASEPLTHIMSYTIK 455
            ..|     .:|:::. ||...|::|..:  .|.|     .||.. ..:|            :.|.
  Fly   362 QTPRMSNVSDEMQIYGYRVAYMSDTEFKFSAGNWSYAKQRDFSFHGGKH------------FIIP 414

  Fly   456 NLHPGGYYEAIVQAKNRYGWNEVSDIFQFVVA 487
            :|.....|.....::|..|.::.|.:..|..|
  Fly   415 HLETNTTYLMRAASRNLAGLSDWSPVKVFTTA 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	2/9 (22%)
		IG_like	109..195	CDD:214653	16/91 (18%)
		Ig	118..191	CDD:143165	14/83 (17%)
		IG_like	205..274	CDD:214653	18/82 (22%)
		IGc2	213..273	CDD:197706	17/73 (23%)
		IGc2	301..367	CDD:197706	17/66 (26%)
		FN3	392..486	CDD:238020	20/107 (19%)
CG33543	NP_001014458.3	IGc2	165..224	CDD:197706	15/61 (25%)
		IG_like	256..336	CDD:214653	20/83 (24%)
		IGc2	263..327	CDD:197706	17/65 (26%)
		FN3	341..445	CDD:238020	21/116 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442850
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830