DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and DIP-beta

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	108/422 - (25%)
Similarity:	171/422 - (40%)	Gaps:	86/422 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSRGHTYRAVVGDTLVLPCQVENLGNF 130
            |..::..:||:                .|::.|..|.|:..........|......|.|.|||..
  Fly    79 GNCIDLTVSNK----------------ISSVGAFEPDFVIPLENVTIAQGRDATFTCVVNNLGGH 127

  Fly   131 -----------VLLWRR--GTNVLTASNIMVTRDERVRL-IDGYN---LEISDLEPQDAGDYVCQ 178
                       .:.|.:  ...:|.....::|.::|:.: .:.||   |.|..::.:|||.|:||
  Fly   128 RVSGDGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQ 192

  Fly   179 ISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTKKSGA----- 238
            ::....:.|..|:|:::||.:....|||.:...:||...|.|:..|:|.|.|.|.::.|.
  Fly   193 VNTDPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRARGHPKPKITWRREDGREIIAR 257

  Fly   239 ----NKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHS 299
                .|:.|:..:|.:|||.|:.|.:.|.|.|.|.|||...|:..|:|.|.:.|.:||....:.:
  Fly   258 NGSHQKTKAQSVEGEMLTLSKITRSEMGAYMCIASNGVPPTVSKRMKLQVHFHPLVQVPNQLVGA 322

  Fly   300 GEGFEAKLVCIVFADPVATVSWY-QNSFPIQSTDRRIMATRAN-----RHMLTIRHIQQEDFGNY 358
            ....:..|:|.|.|.|.|...|. :|...|.:.||..:..:.|     ..:|.|:.:|..|||.|
  Fly   323 PVLTDVTLICNVEASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMILHIKRLQSSDFGGY 387

  Fly   359 SCVADNSLGRSRKYMEL--SGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYRRVQMN 421
            .|::.||:|.:...:.|  ..|||.                   ||.....|.|       |..|
  Fly   388 KCISKNSIGDTEGTIRLYEMERPGK-------------------KILRDDDLNE-------VSKN 426

  Fly   422 ETYQQPGRWHDFI----------LTPEHRPAS 443
            |..|:..|..|..          ..|:..|||
  Fly   427 EVVQKDTRSEDGSRNLNGRLYKDRAPDQHPAS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	9/57 (16%)
		IG_like	109..195	CDD:214653	23/102 (23%)
		Ig	118..191	CDD:143165	20/89 (22%)
		IG_like	205..274	CDD:214653	27/77 (35%)
		IGc2	213..273	CDD:197706	24/68 (35%)
		IGc2	301..367	CDD:197706	22/71 (31%)
		FN3	392..486	CDD:238020	14/62 (23%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	25/110 (23%)
		ig	102..195	CDD:278476	20/92 (22%)
		IG_like	219..307	CDD:214653	30/87 (34%)
		Ig	221..307	CDD:299845	28/85 (33%)
		Ig	311..404	CDD:299845	26/92 (28%)
		IG_like	327..405	CDD:214653	23/77 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442811
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
	4	3.740