DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and dpr8

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001285239.1	Gene:	dpr8 / 32387	FlyBaseID:	FBgn0052600	Length:	344	Species:	Drosophila melanogaster

Alignment Length:	350	Identity:	81/350 - (23%)
Similarity:	142/350 - (40%)	Gaps:	73/350 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GSNSRSMSNVQQSAVAASTLTATLPRFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLW--RRGTN 139
            |::.|..::..|......|...|....:  |.....:||.|:.|.|:|:||||..:.|  .|..:
  Fly    21 GASKRFFTDFLQDLPTPGTGGPTFDTTI--GTNITGLVGKTVKLTCRVKNLGNRTVSWVRHRDIH 83

  Fly   140 VLTASNIMVTRDERVRLI-----DGYNLEISDLEPQDAGDYVCQIS--DKINRDQVHTVEILVPP 197
            :||......|.|:|...:     :.:.|.|...:.:|:|.|.||||  ..|.    |:|.:.:..
  Fly    84 LLTVGRYTYTSDQRFEAMHSPHAEDWTLRIRYAQRKDSGIYECQISTTPPIG----HSVYLNIVE 144

  Fly   198 SVRAIPTSGQLQARKGGPITLEC--KGSGNPVPSIYWT-KKSGANKSTARIG-----DGPILT-- 252
            .|..|....:|...:|..|.|.|  |.:..|.|::.|: .:...|..:.|.|     :..:||
  Fly   145 PVTDIIGGPELHINRGSTINLTCIVKFAPEPPPTVIWSHNREIINFDSPRGGISLVTEKGVLTTS 209

  Fly   253 ---LEKLERQQAGVYQCTADNGVGDPVTVDMRL-DVLYPPDIQVEKSWIHSGEGFEAK------- 306
               ::|...|.:|:|.||..|  .:|.:|.:.: |..:|       :.:|:|....:.
  Fly   210 RLLVQKAITQDSGLYTCTPSN--ANPTSVRVHIVDGEHP-------AAMHTGNNGNSTASQPPVL 265

  Fly   307 -----LVC--IVFADPVATVSWYQNSFP-----IQS----TDRRIMATRANRHMLTIRHIQQEDF 355
                 |.|  ::....||:.|....:.|     :|.    .:.:.|..|:||:...::.:::
  Fly   266 LPLVLLTCSTLMLLQLVASCSTLVPATPPGCRTVQQASTFAEEKAMGQRSNRNCQDLQELEE--- 327

  Fly   356 GNYSCVADNSLGRSRKYMELSGRPG 380
                     |....|:.:|.|..||
  Fly   328 ---------SQDLRRRGVERSAVPG 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	11/46 (24%)
		IG_like	109..195	CDD:214653	29/94 (31%)
		Ig	118..191	CDD:143165	25/81 (31%)
		IG_like	205..274	CDD:214653	21/81 (26%)
		IGc2	213..273	CDD:197706	20/72 (28%)
		IGc2	301..367	CDD:197706	12/88 (14%)
		FN3	392..486	CDD:238020
dpr8	NP_001285239.1	IG_like	51..131	CDD:214653	26/79 (33%)
		V-set	52..143	CDD:284989	29/94 (31%)
		IG_like	153..238	CDD:214653	23/86 (27%)
		ig	153..232	CDD:278476	21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810