DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and Ncam2

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_981954.2	Gene:	Ncam2 / 288280	RGDID:	1303131	Length:	837	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	114/531 - (21%)
Similarity:	203/531 - (38%)	Gaps:	132/531 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 GDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYNLEIS--DLEPQDAGDYVC 177
            |:.:.|.|:.....:..:.|.|       :..::..:|:. ::.|.|.|::  ::..:|.|.|||
  Rat   225 GEEMTLTCKASGSPDPAISWFR-------NGKLIEENEKY-ILKGSNTELTVRNIINKDGGSYVC 281

  Fly   178 QISDKINRDQVHT-VEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTKK------ 235
            :.::|...||... :::.|.|.:..:...   ...:.|.:||.|:..|.|||.|.|.:.
  Rat   282 KATNKAGEDQKQAFLQVFVQPHILQLKNE---TTSENGHVTLICEAEGEPVPEITWKRAIDGVTF 343

  Fly   236 SGANKSTARIGDGPI----------LTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDI 290
            |..:||.    ||.|          |.:..::...:|.|.|.|.:.:|.... .|.||:.|.|..
  Rat   344 SEGDKSP----DGRIEVKGQHGRSSLHIRDVKLSDSGRYDCEAASRIGGHQR-SMHLDIEYAPKF 403

  Fly   291 QVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNS--FPIQSTDRRIMATRANRHMLTIRHIQQE 353
            ...::..:|.||....:.|.|.|:|.|::.|.:..  .|.::|......:...:.:|.|......
  Rat   404 VSNQTMYYSWEGNPINISCDVKANPPASIHWRREKLVLPAKNTTHLKTHSVGRKMILEIAPTSDN 468

  Fly   354 DFGNYSCVADNSLG-----------------RSRKYMELSGRPGAAEFYSPK-WGRSP-DSYNL- 398
            |||.|:|.|.|.:|                 |..|.:|||.......|..|: .|..| ..|.:
  Rat   469 DFGRYNCTATNRIGTRFQEYILELADVPSSPRGVKIIELSQTTAKISFNKPESHGGVPIHHYQVD 533

  Fly   399 -------TWKI------------DSYPP--LEEVRLL---------YRRVQMNET---------- 423
                   ||||            .|..|  ..|||:.         |.::::.:|
  Rat   534 VKEVTSETWKIVRSHGVQTTVVLSSLEPNTTYEVRVAAVNGKGQGDYSKIEIFQTLPVREPSPPS 598

  Fly   424 -YQQP--GRWHDFILTPEHRPASEPLTHIMSY---------------------TIKNLHPGGYYE 464
             :.||  |:.....:|.:....:..|.:|:.|                     .:::|.....||
  Rat   599 IHGQPSSGKSFKISITKQDDGGAPILEYIVKYRSKDKEDQWLEKKVQGNKDHIILEHLQWTMGYE 663

  Fly   465 AIVQAKNRYGWNEVSDIFQFVVATNSQDIGPEDAEVVASSKSRSNSASIGSLPGSTVLHTALLLA 529
            ..:.|.||.|::|.: :::|.:        |....::  ..:..|...:|::.|..|....|:|.
  Rat   664 VQITAANRLGYSEPT-VYEFSM--------PPKPNII--KDTLFNGLGLGAIIGLGVAALLLILV 717

  Fly   530 LALSNCQFDRR 540
            :...:|.|.|:
  Rat   718 VTDVSCFFIRQ 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	3/8 (38%)
		IG_like	109..195	CDD:214653	17/82 (21%)
		Ig	118..191	CDD:143165	16/75 (21%)
		IG_like	205..274	CDD:214653	21/84 (25%)
		IGc2	213..273	CDD:197706	21/75 (28%)
		IGc2	301..367	CDD:197706	19/67 (28%)
		FN3	392..486	CDD:238020	29/159 (18%)
Ncam2	NP_981954.2	IgI_1_NCAM-2	21..113	CDD:409452
		Ig strand B	38..42	CDD:409452
		Ig strand C	50..54	CDD:409452
		Ig strand E	76..80	CDD:409452
		Ig strand F	90..95	CDD:409452
		Ig strand G	104..107	CDD:409452
		IGc2	128..189	CDD:197706
		Ig strand B	130..139	CDD:409353
		Ig strand C	145..153	CDD:409353
		Ig strand C'	156..159	CDD:409353
		Ig strand D	162..167	CDD:409353
		Ig strand E	168..175	CDD:409353
		IgI_1_MuSK	209..298	CDD:409562	17/80 (21%)
		Ig strand B	228..232	CDD:409562	1/3 (33%)
		Ig strand C	241..245	CDD:409562	0/3 (0%)
		Ig strand E	264..268	CDD:409562	1/3 (33%)
		Ig strand F	278..283	CDD:409562	3/4 (75%)
		Ig strand G	291..294	CDD:409562	1/2 (50%)
		Ig	300..397	CDD:416386	26/104 (25%)
		Ig strand A	300..305	CDD:409353	2/4 (50%)
		Ig strand A'	309..313	CDD:409353	0/6 (0%)
		Ig strand B	317..325	CDD:409353	3/7 (43%)
		Ig strand C	331..337	CDD:409353	2/5 (40%)
		Ig strand C'	340..343	CDD:409353	0/2 (0%)
		Ig strand D	353..359	CDD:409353	1/5 (20%)
		Ig strand E	362..368	CDD:409353	1/5 (20%)
		Ig strand F	376..384	CDD:409353	4/7 (57%)
		Ig strand G	387..397	CDD:409353	3/10 (30%)
		Ig_3	401..479	CDD:404760	20/77 (26%)
		Ig strand B	418..422	CDD:409353	0/3 (0%)
		Ig strand C	431..435	CDD:409353	0/3 (0%)
		Ig strand E	458..462	CDD:409353	1/3 (33%)
		Ig strand F	472..477	CDD:409353	2/4 (50%)
		Ig strand G	486..489	CDD:409353	0/2 (0%)
		FN3	496..588	CDD:238020	20/91 (22%)
		fn3	594..678	CDD:394996	15/83 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900