DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and dpr9

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001287332.1	Gene:	dpr9 / 2768670	FlyBaseID:	FBgn0038282	Length:	602	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	111/489 - (22%)
Similarity:	164/489 - (33%)	Gaps:	162/489 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GALAPP----ITAHASANANASGLRKSSQRRNRAPLQMNCPILIVISLGWLLHAHAGSGGFAVEA 71
            |..|.|    |....|.| |:||..|:.                        |..||||..:..|
  Fly   158 GEAAAPGPTGIDGSGSGN-NSSGNNKNG------------------------HPAAGSGAASESA 197

  Fly    72 AISNRGSNSR-----------SMSNVQQSAVAASTLTATL------------------PRF---L 104
            |::...|.|.           |.|..:.|:.:::|.::.|                  |.|   .
  Fly   198 ALTTDASRSSVGGATTITGIPSSSLHKASSASSNTFSSQLASGFHRNSIDLEEARNAGPYFDKAF 262

  Fly   105 SRGHTYRAVVGDTLVLPCQVENLGNFVLL----W--RRGTNVLTASNIMVTRDERVRLI-----D 158
            |:..|  |::|.|..|.|:|:||||..:|    |  .|..::||......|.|:|.|.|     :
  Fly   263 SKNVT--ALLGKTAYLNCRVKNLGNKTMLLQVSWVRHRDIHLLTVGRYTYTSDQRFRAIHQPQTE 325

  Fly   159 GYNLEISDLEPQDAGDYVCQISDKINRDQVHTVEI-LVPPSVRAIPTSGQLQARKGGPITLEC-- 220
            .:.|:|...:.:|:|.|.||:|...:..  |.:.: :|.||...| .:..|....|..|.|.|
  Fly   326 DWMLQIKYPQHRDSGIYECQVSTTPHMS--HYIHLNVVEPSTEII-GAPDLYIESGSTINLTCII 387

  Fly   221 KGSGNPVPSIYW----------------TKKSGANKSTARIGD--GPILTLEKLERQQAGVYQCT 267
            :.|..|...|:|                :.:.|.:..|.: ||  ...|.::......:|.|||.
  Fly   388 QNSPEPPAYIFWNHNNAFPSHPQIINYDSPRGGVSVVTNK-GDTTTSFLLIKSARPSDSGHYQCN 451

  Fly   268 ADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKL-----VCIVFADPVATV------SW 321
            ..|.....|||.:...|.:.....|..|....|....:.|     ||:    ||..:      .|
  Fly   452 PSNAKPKSVTVHVLNGVSHSVSRGVPSSNAARGTSASSPLAHSLSVCV----PVCVLLQLGACRW 512

  Fly   322 YQNSF--------PIQSTDRRIMATRAN-----------RHMLTI--------------RHIQQE 353
            .....        |::|| ||....|..           ||.|..              :..||:
  Fly   513 IAALLGAALATPPPLRST-RRATGERPGSPGCAPIACDMRHFLASVLRWQWRWCWRWHWKGTQQQ 576

  Fly   354 DFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSP 387
            |              .|.|::...|..||....|
  Fly   577 D--------------PRHYLKPQSRRVAAACRQP 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	21/92 (23%)
		IG_like	109..195	CDD:214653	30/97 (31%)
		Ig	118..191	CDD:143165	26/83 (31%)
		IG_like	205..274	CDD:214653	19/88 (22%)
		IGc2	213..273	CDD:197706	18/79 (23%)
		IGc2	301..367	CDD:197706	18/109 (17%)
		FN3	392..486	CDD:238020
dpr9	NP_001287332.1	Ig	263..361	CDD:299845	31/101 (31%)
		IG_like	263..360	CDD:214653	31/100 (31%)
		IG_like	371..464	CDD:214653	22/93 (24%)
		IGc2	377..456	CDD:197706	18/79 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810