DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and NEGR1

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_776169.2	Gene:	NEGR1 / 257194	HGNCID:	17302	Length:	354	Species:	Homo sapiens

Alignment Length:	330	Identity:	96/330 - (29%)
Similarity:	150/330 - (45%)	Gaps:	33/330 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SNVQQSAVAASTLTATLPRFLSRGHT----YRAV------VGDTLVLPCQVENLGNFVLLWRRGT 138
            ||...:||..| |...||..|..|.:    :.||      .|||.||.|.:|: |.....|...:
Human    13 SNQWLAAVLLS-LCCLLPSCLPAGQSVDFPWAAVDNMMVRKGDTAVLRCYLED-GASKGAWLNRS 75

  Fly   139 NVLTASNIMVTRDERVRLID----GYNLEISDLEPQDAGDYVCQISDK--INRDQVHTVEILVPP 197
            :::.|.....:.|.||.:..    .|:|:|.:::..|.|.|.|.:..:  ....||| :.:.|||
Human    76 SIIFAGGDKWSVDPRVSISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTMQVH-LTVQVPP 139

  Fly   198 SVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTKKSGANKSTARIGDGPILTLEKLERQQAG 262
            .:..|  |..:...:|..:||.|..:|.|.|||.|...|.:.|.   ..:|..|.:..:.|.|||
Human   140 KIYDI--SNDMTVNEGTNVTLTCLATGKPEPSISWRHISPSAKP---FENGQYLDIYGITRDQAG 199

  Fly   263 VYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFP 327
            .|:|:|:|.|..|....:::.|.:.|.||..||...: .|....:.|.....|.....||:....
Human   200 EYECSAENDVSFPDVRKVKVVVNFAPTIQEIKSGTVT-PGRSGLIRCEGAGVPPPAFEWYKGEKK 263

  Fly   328 IQSTDRRIMATR-ANRHMLTIRHIQQEDFGNYSCVADNSLGRSRKYMELS-------GRPGAAEF 384
            :.:..:.|:... :.|.:||:.::.||.||||:|||.|.||.:...:.|:       |..|:|:.
Human   264 LFNGQQGIIIQNFSTRSILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNPPSTAQYGITGSADV 328

  Fly   385 YSPKW 389
            ....|
Human   329 LFSCW 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	18/49 (37%)
		IG_like	109..195	CDD:214653	25/101 (25%)
		Ig	118..191	CDD:143165	20/78 (26%)
		IG_like	205..274	CDD:214653	24/68 (35%)
		IGc2	213..273	CDD:197706	22/59 (37%)
		IGc2	301..367	CDD:197706	19/66 (29%)
		FN3	392..486	CDD:238020
NEGR1	NP_776169.2	IG	47..135	CDD:214652	23/89 (26%)
		IGc2	152..210	CDD:197706	22/60 (37%)
		Ig_3	225..301	CDD:372822	23/76 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143458
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X97
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740