DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and Igsf9b

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_011240777.1	Gene:	Igsf9b / 235086	MGIID:	2685354	Length:	1443	Species:	Mus musculus

Alignment Length:	441	Identity:	111/441 - (25%)
Similarity:	168/441 - (38%)	Gaps:	105/441 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 RSMSNVQQSAVAASTLT-------ATLPRFLSRGHTYRAVVGDTLVLPCQVEN--LGN---FVLL 133
            |||...|.|..|...|.       ...|.|:    |.||  |:.:||.|.|.:  .|.   :|:.
Mouse     5 RSMFKAQDSLSAGKNLVPGGAHGLREEPEFV----TARA--GEGVVLRCDVIHPVTGQPPPYVVE 63

  Fly   134 W-RRGTNV-------LTASNIMVTRDERVRLIDGYNLEISDLEPQDAGDYVCQISDKINRDQ--- 187
            | :.|..:       ....::......|..|.|..:|.:..:..:|.|.|.|::   :..||
Mouse    64 WFKFGVPIPIFIKFGYYPPHVDPEYAGRASLHDKASLRLEQVRSEDQGWYECKV---LMLDQQYD 125

  Fly   188 -------VHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWTKKSGANKSTAR- 244
                   || :.|..||:....|.. .::|::||.||:.|...|||.|.:.|.|:.....::|:
Mouse   126 TFHNGSWVH-LTINAPPTFTETPPQ-YIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASAKY 188

  Fly   245 -IGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLV 308
             :.||. ||:..:.|:..|.|.|.|.:..|:.|.. ..|.|..||.|......|......:|.|.
Mouse   189 QVSDGS-LTVTSVSREDRGAYTCRAYSIQGEAVHT-THLLVQGPPFIVSPPENITVNISQDALLT 251

  Fly   309 CIVFADP-VATVSWY--------QNSFPIQSTDRRIMATRANRHMLTIRHIQQEDFGNYSCVADN 364
            |...|.| ..|.:||        ||...::.   ||:....    |.|..::.||.|.|:||..|
Mouse   252 CRAEAYPGNLTYTWYWQDENVYFQNDLKLRV---RILIDGT----LIIFRVKPEDAGKYTCVPSN 309

  Fly   365 SLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYRRVQMNETYQQPGR 429
            |||||         |.|:.:.:.:                ||.        |.:.|......|..
Mouse   310 SLGRS---------PSASAYLTVQ----------------YPA--------RVLNMPPVIYVPVG 341

  Fly   430 WHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSD 480
            .|.:|..|..   :||...::.:. |:..|       :|.:...||..:.|
Mouse   342 IHGYIRCPVD---AEPPATVVKWN-KDGRP-------LQVEKNLGWTLMED 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	16/49 (33%)
		IG_like	109..195	CDD:214653	25/108 (23%)
		Ig	118..191	CDD:143165	20/95 (21%)
		IG_like	205..274	CDD:214653	22/70 (31%)
		IGc2	213..273	CDD:197706	21/61 (34%)
		IGc2	301..367	CDD:197706	22/74 (30%)
		FN3	392..486	CDD:238020	16/89 (18%)
Igsf9b	XP_011240777.1	Ig	43..117	CDD:319273	16/73 (22%)
		I-set	141..227	CDD:369462	27/88 (31%)
		Ig	231..323	CDD:386229	31/107 (29%)
		Ig	<355..416	CDD:386229	6/35 (17%)
		Ig	440..504	CDD:319273
		FN3	512..607	CDD:238020
		FN3	623..705	CDD:238020
		PHA03247	<900..1248	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810