DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klg and zig-3

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_509336.1	Gene:	zig-3 / 192088	WormBaseID:	WBGene00006980	Length:	251	Species:	Caenorhabditis elegans

Alignment Length:	250	Identity:	56/250 - (22%)
Similarity:	83/250 - (33%)	Gaps:	75/250 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 PQDAGDYVCQISDKINRDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPVPSIYWT 233
            |..:|:....:|:.:.  ::.:..:...||::.|..........|..:||.|.....|...|||
Worm    16 PLSSGEMRAAVSNLVR--EIDSTHLTTKPSLKIIEGLEDNTVSTGESVTLRCDVLSTPTGVIYW- 77

  Fly   234 KKSGANKSTARI-GDGPILTLEKL----------------------ERQQAGVYQCTADNGVGDP 275
                 .|...|| ||..:...||:                      .....|.|:|.|.|| .|.
Worm    78 -----EKDGQRIQGDKELNVFEKVLNAMGPTVESGIITSSYQIPCANLHHIGSYKCVATNG-HDT 136

  Fly   276 VTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMATRA 340
            |....::.|                ||...|......:.||.|:| .::.|.:|.....::. ||
Worm   137 VESSAKISV----------------EGQTVKCKSTRRSAPVITMS-TESRFELQDNAATLIC-RA 183

  Fly   341 NRHM-------------------------LTIRHIQQEDFGNYSCVADNSLGRSR 370
            :|..                         |.||.||..|.|:|.|:|.|..|.||
Worm   184 DRRANWNWMFEDKKIDFDSGRYELLPSGDLLIRKIQWSDMGSYFCIAHNKYGESR 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518
		IG_like	109..195	CDD:214653	3/25 (12%)
		Ig	118..191	CDD:143165	3/21 (14%)
		IG_like	205..274	CDD:214653	21/91 (23%)
		IGc2	213..273	CDD:197706	21/82 (26%)
		IGc2	301..367	CDD:197706	23/90 (26%)
		FN3	392..486	CDD:238020
zig-3	NP_509336.1	I-set	45..145	CDD:254352	24/106 (23%)
		Ig	61..142	CDD:143165	22/87 (25%)
		IG_like	177..244	CDD:214653	16/62 (26%)
		Ig	<191..237	CDD:299845	12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900