DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and DSCAM

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001380.2	Gene:	DSCAM / 1826	HGNCID:	3039	Length:	2012	Species:	Homo sapiens

Alignment Length:	709	Identity:	149/709 - (21%)
Similarity:	240/709 - (33%)	Gaps:	225/709 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNIISRSIRTGALAPPITAHASANANASGLRKSSQRRN-RAPLQMNCPILIVISLGWLLHAHAGS 64
            :||.|..:|.|.:     ...:|| |::|:.....|.| |.|..:.....|....|...:.|...
Human   469 LNISSSQVRDGGV-----YRCTAN-NSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527

  Fly    65 GGFAV-----------------EAAISNRGSNSRSMSNVQQ-----------------SAVAAST 95
            .|:..                 :.|..|.|  :..:|:||:                 |...:..
Human   528 IGYPYYSIKWYKNSNLLPFNHRQVAFENNG--TLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVH 590

  Fly    96 LTATLPRFLSRGHTYRAVVGDTLVLPCQVENLGN--FVLLWRR------GTNVLTASNIMVTRDE 152
            :|..:|.|:......|..:|..:.:||.|.: |:  ..:.|::      |:..:|..||..|.
Human   591 VTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS-GDLPITITWQKDGRPIPGSLGVTIDNIDFTS-- 652

  Fly   153 RVRLIDGYNLEISDLEPQDAGDYVCQISDKINRDQVHTVE------ILVPPSVRAIPTSGQLQAR 211
                    :|.||:|.....|:|.|     |.|::...||      :.|||.....|.  .....
Human   653 --------SLRISNLSLMHNGNYTC-----IARNEAAAVEHQSQLIVRVPPKFVVQPR--DQDGI 702

  Fly   212 KGGPITLECKGSGNPVPSIYWTKKSGA----------NKSTARIGDGPILTLEKLERQQAGVYQC 266
            .|..:.|.|...|.|||:|.|....||          |.....:.:|.:| ::.:..:.:|.|.|
Human   703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYYLC 766

  Fly   267 TADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQST 331
            ...|.||..|:..|.|.|..|..|....:...:.:|.:.::.|....:....|.|        ..
Human   767 KVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRW--------EK 823

  Fly   332 DRRIMATRANRHMLTIRHIQQ-------------EDFGNYSCVADNSLGRSRKYMELSGR----P 379
            :.||:.....|::::.:.:.:             ||.|.:||.|.||.|..|..::|:.:    |
Human   824 EDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPPDP 888

  Fly   380 GAAEFYSPK-------W-----GRSP------------DSY-------------NLTWKIDSYP- 406
            ...|....|       |     |.||            ||:             |....||.:|
Human   889 PEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPS 953

  Fly   407 ---------------------------------PLEEVRL----------------------LYR 416
                                             |.:||.|                      :.|
Human   954 STYSIRMYAKNRIGKSEPSNELTITADEAAPDGPPQEVHLEPISSQSIRVTWKAPKKHLQNGIIR 1018

  Fly   417 RVQMN-ETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSD 480
            ..|:. ..|...|.:...|::.:....||      .||:.||:....|..:|||.||.|....|
Human  1019 GYQIGYREYSTGGNFQFNIISVDTSGDSE------VYTLDNLNKFTQYGLVVQACNRAGTGPSS- 1076

  Fly   481 IFQFVVATNSQDI---GPEDAEVVASS--------KSRSNSASIGSLPGSTVLHTALLL 528
              |.::.|..:|:   .||:.:.:|:|        .:.|..|..|.|.|..|::.|.|:
Human  1077 --QEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLM 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	15/94 (16%)
		IG_like	109..195	CDD:214653	23/99 (23%)
		Ig	118..191	CDD:143165	19/80 (24%)
		IG_like	205..274	CDD:214653	19/78 (24%)
		IGc2	213..273	CDD:197706	18/69 (26%)
		IGc2	301..367	CDD:197706	15/78 (19%)
		FN3	392..486	CDD:238020	32/175 (18%)
DSCAM	NP_001380.2	Ig	45..113	CDD:319273
		I-set	235..310	CDD:254352
		I-set	315..385	CDD:333254
		Ig_3	407..488	CDD:316449	7/24 (29%)
		IGc2	518..575	CDD:197706	9/58 (16%)
		I-set	596..686	CDD:333254	25/105 (24%)
		Ig_DSCAM	707..784	CDD:143211	22/77 (29%)
		Ig	802..889	CDD:325142	18/94 (19%)
		FN3	885..978	CDD:238020	13/92 (14%)
		FN3	986..1083	CDD:238020	24/105 (23%)
		FN3	1091..1184	CDD:238020	12/43 (28%)
		FN3	1189..1278	CDD:238020
		Ig	1303..1369	CDD:319273
		FN3	1380..1470	CDD:238020
		FN3	1486..1555	CDD:238020
		Required for netrin-mediated axon repulsion of neuronal growth cones. /evidence=ECO:0000250\|UniProtKB:Q9ERC8	1617..2012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1718..1810
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1855..1883
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1971..2012
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810