DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and wrk-1

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001024651.1	Gene:	wrk-1 / 181093	WormBaseID:	WBGene00006942	Length:	452	Species:	Caenorhabditis elegans

Alignment Length:	475	Identity:	121/475 - (25%)
Similarity:	201/475 - (42%)	Gaps:	77/475 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LTATLPRFLSRGHTYRAVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGY 160
            :.:|..:..::|.|..|..|::|.|.|:||: .:..::||:.|.|:...      ||.:....||
Worm    13 IASTSAQIRTKGGTLIAKEGESLTLRCEVED-PSVAIIWRKNTEVVAVD------DEILDTYGGY 70

  Fly   161 N---------LEISDLEPQDAGDYVCQISD-KINRDQVHTVEILVP------PSVRAIPTSGQLQ 209
            .         |.|..:||.::.:|.|.::: :::...|..|::..|      |.|...|.:|...
Worm    71 EISMEGSTSVLTIKRVEPINSANYSCALAEPEVSVTFVIKVQVFKPTQVSVKPLVVISPDTGVYH 135

  Fly   210 ARKGGP---ITLECKGSGNPVPSIYWTKKSG-ANKSTARIGDGPILTLEKLERQQAGVYQCTADN 270
            ||.|..   ||...| .|||.|.:.|||::. ..:...|...|..:.:.::::..||.|.|.|:|
Worm   136 ARVGEKNLVITCHVK-EGNPKPGVVWTKQAAKLPEDIKREHGGARIVITEVKKHHAGKYNCLAEN 199

  Fly   271 GVG-DPVTVDMRLDVLYP-PDIQVEKSWIHSGEGF-------EAKLVCIVFADPVATVSWYQNSF 326
            ..| |..|:|  :.|..| ...:.||.|:.:.:.|       .|...|.....||..|.|..|.:
Worm   200 IAGSDRATID--IHVAEPLQGEREEKPWVKNEDTFIPVRKNQNASFWCTYDGTPVPQVEWLFNGY 262

  Fly   327 PIQSTDRRIMAT-----RAN---RHMLTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAE 383
            .|...|.:...|     |.|   :..||:..|.:|.||:|:|...|.||.....:.:|||||..:
Worm   263 KINFNDEKFKKTSETAQRLNGYSKSTLTVGDISEEAFGDYACRISNKLGSVTAVVHVSGRPGPPQ 327

  Fly   384 FYSPKWGRSPDSYNLTWKIDSYPPLEEVRLLYRRVQMNETYQQPGRWHDFILTPEHRPASEPLTH 448
            .       |.|...|||.:.::..:.|.:|.:|  ..|..:..|...:...:........:..||
Worm   328 L-------SFDESELTWTVRAFDKILEYQLCHR--LENADHFLPEDCNSVRVKKSDNNGDDKWTH 383

  Fly   449 IMSYTIKNLHPGGYYEAIVQAKNRYGWNEVSDIFQFVVATNSQDIGPEDA---EVVASSKSRSNS 510
            .:..: ..|..|..|...::|:|..||..::                :||   |:....|..:..
Worm   384 TIDLS-TFLEHGNKYHVQLKARNALGWGSMA----------------KDALHVELQRIEKEEAKG 431

  Fly   511 ASIGSLPGSTVLHTALLLAL 530
            |||.|:. |::|.|.:.:.|
Worm   432 ASIISII-SSILVTLVTMYL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	8/27 (30%)
		IG_like	109..195	CDD:214653	24/95 (25%)
		Ig	118..191	CDD:143165	20/82 (24%)
		IG_like	205..274	CDD:214653	23/73 (32%)
		IGc2	213..273	CDD:197706	19/63 (30%)
		IGc2	301..367	CDD:197706	22/80 (28%)
		FN3	392..486	CDD:238020	19/93 (20%)
wrk-1	NP_001024651.1	IG_like	25..113	CDD:214653	24/94 (26%)
		IGc2	31..96	CDD:197706	19/71 (27%)
		IG_like	132..212	CDD:214653	26/82 (32%)
		IGc2	142..202	CDD:197706	18/60 (30%)
		IG_like	235..320	CDD:214653	23/84 (27%)
		Ig	245..318	CDD:143165	22/72 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I8517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H106843
Inparanoid	1	1.050	118	1.000	Inparanoid score	I3357
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28857
OrthoDB	1	1.010	-	-		D332048at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14108
orthoMCL	1	0.900	-	-		OOG6_114631
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17012
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.910