DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and rig-3

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_509155.1	Gene:	rig-3 / 180958	WormBaseID:	WBGene00004370	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	110/538 - (20%)
Similarity:	194/538 - (36%)	Gaps:	141/538 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 AAISNRGSNSRSMSN---VQQSAVAASTLTATLPRFLSRGHTYRAVVGDTLVLPCQVEN---LGN 129
            :|:|...|.|.:.:|   :...|:...|.|.|:..            |..|::.|..|:   :..
Worm    19 SAVSASDSPSSNEANPIVISSEAMDYDTNTITVRE------------GKKLMVSCVFESDEQIHK 71

  Fly   130 FVLLWRR--GTNVLTASN---IMVTRDERVRLIDGYNLEISDLEPQDAGDYVCQISDKINRDQVH 189
            ..|||::  |.|:...||   ..|..:|:.......:|..|.:..:|.|.|.|........:...
Worm    72 SDLLWKQANGNNIDGESNPSLFSVILNEKGSKHRKTSLHFSSVHTRDTGLYTCTGRTAGGENFEK 136

  Fly   190 TVEILVPPSVRAIPTSGQLQARKGGPITLEC---------------KGSGNPVPSIYWTKKSGAN 239
            |::::|.|::..........|..|.|||::|               .|:|.|:....||  ...|
Worm   137 TIKLVVLPAIEWNDKDTVKGALLGEPITIDCGVKGPSGKEPMIQMTNGNGEPLDEEIWT--IAGN 199

  Fly   240 KSTARIGDGPILTLEKLERQQA---------GVYQCTADNGVGDPVT--VDMRLDVLYPPDIQVE 293
            ::          |::.|:::.|         .::|.|:....  ||.  .|:.::|...|:.:.|
Worm   200 EA----------TIDSLKKEHAELTVSCITIEMHQETSKEEF--PVVDRKDVNIEVYTLPEFETE 252

  Fly   294 KS---WIHSGEGFEAKLVCIVFAD--PVATVSWYQNSFPIQSTDR-RI---MATRANRHMLTIRH 349
            :|   .:......:|.:.|.|...  ||...::|.....|:.:|: .|   :......| |.|.:
Worm   253 ESVQYTVIDNHVRDAIIYCNVTHSFPPVRHYTFYHGDEEIKMSDKFNIFVNVGVSQGAH-LKIHN 316

  Fly   350 IQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDS-YNLTWKIDSYP-----PL 408
            :.:.|.|.|.|.|:|...:|...:.|......||   ||.....|. :::.||::|..     |:
Worm   317 VNENDLGTYKCEANNIKAKSYHTIHLREANAPAE---PKVTLIEDKRHSIIWKVESIDRDPDLPM 378

  Fly   409 EEVRLLYRRV-----------QMNETYQQPGRW--HDFILTPEHRPASEPLTHIMSYTIKNLHPG 460
            ..|.:.:.|.           .:::.|     |  |...:.                  :|:...
Worm   379 TAVEIRHLRAGTAEASGVSDEDISDAY-----WKSHSIFMQ------------------RNIKDD 420

  Fly   461 GYYEAI-VQAKNRYGW-----NEVSDIFQFVVATNSQDIGPEDAEVVASSKSRSNSASIGSLPGS 519
            |.||.. ::..:.|.|     ||..  |...|...::.:...|.|::       :|||....|
Worm   421 GIYEINGLRHGHEYVWRFRQINEAG--FGDSVVLRAKTLDDHDLEMM-------DSASDSKFP-- 474

  Fly   520 TVLHTALLLALALSNCQF 537
                  |.||.....|.|
Worm   475 ------LALATLFFVCLF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	12/55 (22%)
		IG_like	109..195	CDD:214653	20/93 (22%)
		Ig	118..191	CDD:143165	18/80 (23%)
		IG_like	205..274	CDD:214653	17/92 (18%)
		IGc2	213..273	CDD:197706	16/83 (19%)
		IGc2	301..367	CDD:197706	18/71 (25%)
		FN3	392..486	CDD:238020	19/118 (16%)
rig-3	NP_509155.1	IG_like	48..142	CDD:214653	22/105 (21%)
rig-3	NP_509155.1	Ig	267..341	CDD:319273	19/74 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810