DRSC/TRiP Functional Genomics Resources

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Protein Alignment klg and unc-89

DIOPT Version :10

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_001020985.1	Gene:	unc-89 / 171990	WormBaseID:	WBGene00006820	Length:	8081	Species:	Caenorhabditis elegans

Alignment Length:	535	Identity:	117/535 - (21%)
Similarity:	207/535 - (38%)	Gaps:	98/535 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IISRSIRTGALAPPITAHASANANASGLRKSSQRRNRAPLQMNCPILIVISLG-------WL--- 57
            |.:.||.|......||....|.....||:|:|.:...       .|.:.:.:|       |.
Worm  3168 IATNSIGTATSTSKITTKVEAPVFEQGLKKTSVKEKE-------EIKMEVKVGGSAPDVEWFKDD 3225

  Fly    58 ----------LHAHAGSGGFAV---EAAISNRGSNSRSMSN----VQQSAVAASTLTATLPRFLS 105
                      :..:..:|.|.:   :||.::.|..:...||    .:.||.|..|.:...|.|:.
Worm  3226 KPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSAEAEVTQSLEKPTFVR 3290

  Fly   106 RGHTYRAVVGDTLVLPCQVENLGNFVLLW-RRGTNVLTASNIMVTRDERVRLIDG---YNLEISD 166
            ...|....:.:|..|...|:.:.:..:.| :.|..|.|.|:.::.:      ::|   |::.|.|
Worm  3291 ELVTTEVKINETATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAK------VEGSGSYSITIKD 3349

  Fly   167 LEPQDAGDYVCQISDKINRDQVH----TVEILVPPSVRAIPTSGQLQARKGGPITLECKGSGNPV 227
            ...:|:|.|.|:.::.....:..    .|:.||||..  :.....|:.::....||..|..|.|.
Worm  3350 ARLEDSGKYACRATNPAGEAKTEANFAVVKNLVPPEF--VEKLSPLEVKEKESTTLSVKVVGTPE 3412

  Fly   228 PSIYWTKKSG---------ANKSTARIGDGPILTLEKLERQQAGVYQCTADNGVGDPVTVDMRLD 283
            ||:.|.|...         ..|.|| :|... ||:....:...|:|.|.|.|..|:.:|. ....
Worm  3413 PSVEWFKDDTPISIDNVHVIQKQTA-VGSFS-LTINDARQGDVGIYSCRARNEAGEALTT-ANFG 3474

  Fly   284 VL---YPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIMA--TRANRH 343
            ::   .||:...:...:...|.....|...|...||..|.|:::..||...:..|.|  ..:..|
Worm  3475 IIRDSIPPEFTQKLRPLEVREQETLDLKVTVIGTPVPNVEWFKDDKPINIDNSHIFAKDEGSGHH 3539

  Fly   344 MLTIRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKW--GRSPDSYNLTWKIDSYP 406
            .|||:..:.||.|.|:|.|.|..|.::....::.:   .|..:|.:  |..|      ::::...
Worm  3540 TLTIKQARGEDVGVYTCKATNEAGEAKTTANMAVQ---EEIEAPLFVQGLKP------YEVEQGK 3595

  Fly   407 PLEEVRLLYRRVQMNETYQQPGRWHDFILTPEHRPASEPLTHIM-------SYT--IKNLHPGGY 462
            |.|.|      |::....:...:|.     .:..|.:....|::       |:|  ||:.:...:
Worm  3596 PAELV------VRVEGKPEPEVKWF-----KDGVPIAIDNQHVIEKKGENGSHTLVIKDTNNADF 3649

  Fly   463 YEAIVQAKNRYGWNE 477
            .:...||.|:.|.:|
Worm  3650 GKYTCQATNKAGKDE 3664

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	IG_like	109..195	CDD:214653	18/93 (19%)
		Ig strand B	118..122	CDD:409353	1/3 (33%)
		Ig strand C	131..135	CDD:409353	1/4 (25%)
		Ig strand E	160..164	CDD:409353	1/3 (33%)
		Ig strand F	174..179	CDD:409353	2/4 (50%)
		Ig strand G	188..191	CDD:409353	0/6 (0%)
		Ig_3	196..270	CDD:464046	22/82 (27%)
		Ig_3	287..364	CDD:464046	23/78 (29%)
		FN3	392..486	CDD:238020	17/95 (18%)
unc-89	NP_001020985.1	SH3	65..124	CDD:473055
		RhoGEF	153..328	CDD:238091
		PH_unc89	341..455	CDD:270134
		Ig strand B	565..569	CDD:409405
		I-set	<570..638	CDD:400151
		Ig strand C	578..582	CDD:409405
		Ig strand E	604..608	CDD:409405
		Ig strand F	618..623	CDD:409405
		Ig strand G	631..634	CDD:409405
		I-set	648..737	CDD:400151
		Ig strand B	665..669	CDD:409353
		Ig strand C	678..682	CDD:409353
		Ig strand E	703..707	CDD:409353
		Ig strand F	717..722	CDD:409353
		Ig strand G	730..733	CDD:409353
		I-set	748..837	CDD:400151
		Ig strand B	765..769	CDD:409353
		Ig strand C	778..782	CDD:409353
		Ig strand E	803..807	CDD:409353
		Ig strand F	817..822	CDD:409353
		Ig strand G	830..833	CDD:409353
		Ig	844..935	CDD:472250
		Ig strand B	861..865	CDD:409405
		Ig strand C	874..878	CDD:409405
		Ig strand E	900..904	CDD:409405
		Ig strand F	915..920	CDD:409405
		Ig strand G	928..931	CDD:409405
		Ig	946..1034	CDD:472250
		Ig strand B	963..967	CDD:409543
		Ig strand C	976..980	CDD:409543
		Ig strand E	1002..1006	CDD:409543
		Ig strand F	1010..1019	CDD:409543
		Ig strand G	1027..1030	CDD:409543
		I-set	1044..1133	CDD:400151
		Ig strand B	1061..1065	CDD:409353
		Ig strand C	1074..1078	CDD:409353
		Ig strand E	1099..1103	CDD:409353
		Ig strand F	1113..1118	CDD:409353
		Ig strand G	1126..1129	CDD:409353
		Ig	1140..1237	CDD:472250
		Ig strand B	1157..1161	CDD:409543
		Ig strand C	1170..1174	CDD:409543
		Ig strand E	1200..1204	CDD:409543
		Ig strand F	1208..1222	CDD:409543
		Ig strand G	1230..1233	CDD:409543
		PTZ00121	<1304..1992	CDD:173412
		Ig	1982..2068	CDD:472250
		Ig strand B	1999..2003	CDD:409353
		Ig strand C	2010..2014	CDD:409353
		Ig strand E	2036..2040	CDD:409353
		Ig strand F	2048..2053	CDD:409353
		Ig strand G	2061..2064	CDD:409353
		I-set	2081..2164	CDD:400151
		Ig strand B	2092..2096	CDD:409406
		Ig strand C	2105..2109	CDD:409406
		Ig strand E	2130..2134	CDD:409406
		Ig strand F	2144..2149	CDD:409406
		Ig strand G	2157..2160	CDD:409406
		Ig	2171..2262	CDD:472250
		Ig strand B	2188..2192	CDD:409353
		Ig strand C	2202..2206	CDD:409353
		Ig strand E	2226..2232	CDD:409353
		Ig strand F	2242..2247	CDD:409353
		Ig strand G	2255..2258	CDD:409353
I-set	2269..2360	CDD:400151
Ig strand B	2286..2290	CDD:409405
Ig strand C	2299..2303	CDD:409405
Ig strand E	2326..2330	CDD:409405
Ig strand F	2340..2345	CDD:409405
Ig strand G	2353..2356	CDD:409405
I-set	2367..2456	CDD:400151
Ig strand B	2384..2388	CDD:409543
Ig strand C	2397..2401	CDD:409543
Ig strand E	2422..2426	CDD:409543
Ig strand F	2436..2441	CDD:409543
Ig strand G	2449..2452	CDD:409543
Ig	2463..2554	CDD:472250
Ig strand B	2480..2484	CDD:409405
Ig strand C	2494..2498	CDD:409405
Ig strand E	2520..2524	CDD:409405
Ig strand F	2534..2539	CDD:409405
Ig strand G	2547..2550	CDD:409405
Ig	2563..2652	CDD:472250
Ig strand C	2593..2597	CDD:409405
Ig strand E	2618..2622	CDD:409405
Ig strand F	2632..2637	CDD:409405
Ig strand G	2645..2648	CDD:409405
I-set	2659..2747	CDD:400151
Ig strand B	2675..2679	CDD:409543
Ig strand C	2688..2692	CDD:409543
Ig strand E	2713..2717	CDD:409543
Ig strand F	2727..2732	CDD:409543
Ig strand G	2740..2743	CDD:409543
Ig	2754..2843	CDD:472250
Ig strand C	2784..2788	CDD:409353
Ig strand E	2809..2813	CDD:409353
Ig strand F	2824..2829	CDD:409353
Ig strand G	2837..2840	CDD:409353
I-set	2887..2981	CDD:400151
Ig strand B	2904..2908	CDD:409405
Ig strand C	2917..2921	CDD:409405
Ig strand E	2947..2951	CDD:409405
Ig strand F	2961..2966	CDD:409405
Ig strand G	2974..2977	CDD:409405
I-set	2994..3082	CDD:400151
Ig strand B	3011..3015	CDD:409353
Ig strand C	3024..3028	CDD:409353
Ig strand E	3046..3052	CDD:409353
Ig strand F	3062..3067	CDD:409353
Ig strand G	3075..3078	CDD:409353
Ig	3087..3183	CDD:472250	4/14 (29%)
Ig strand B	3104..3108	CDD:409543
Ig strand C	3117..3121	CDD:409543
Ig strand E	3149..3154	CDD:409543