DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and Dscam

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	XP_038943864.1	Gene:	Dscam / 171119	RGDID:	619992	Length:	2034	Species:	Rattus norvegicus

Alignment Length:	711	Identity:	152/711 - (21%)
Similarity:	245/711 - (34%)	Gaps:	229/711 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNIISRSIRTGALAPPITAHASANANASGLRKSSQRRN-RAPLQ----------------MNCPI 48
            :||.|..:|.|.:     ...:|| |::|:.....|.| |.|..                ::|.:
  Rat   469 LNISSSQVRDGGV-----YRCTAN-NSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRV 527

  Fly    49 L--IVISLGWLLHA------HAGSGGFAVEAAISNRGSNSRSMSNVQQ----------------- 88
            :  ...|:.|..:|      |.       :.|..|.|  :..:|:||:
  Rat   528 IGYPYYSIKWYKNANLLPFNHR-------QVAFENNG--TLKLSDVQKEVDEGEYTCNVLVQPQL 583

  Fly    89 SAVAASTLTATLPRFLSRGHTYRAVVGDTLVLPCQVENLGN--FVLLWRRGTNVLTASNIMVTRD 151
            |...:..:|..:|.|:......|..:|..:.:||.|.: |:  ..:.|::....:.|| :.||.|
  Rat   584 STSQSVHVTVKVPPFIQPFEFPRFSIGQRVFIPCVVVS-GDLPITITWQKDGRPIPAS-LGVTID 646

  Fly   152 ERVRLID-GYNLEISDLEPQDAGDYVCQISDKINRDQVHTVE------ILVPPSVRAIPTSGQLQ 209
            .    || ..:|.||:|.....|:|.|     |.|::...||      :.|||.....|.  ...
  Rat   647 N----IDFTSSLRISNLSLMHNGNYTC-----IARNEAAAVEHQSQLIVRVPPKFVVQPR--DQD 700

  Fly   210 ARKGGPITLECKGSGNPVPSIYWTKKSGA----------NKSTARIGDGPILTLEKLERQQAGVY 264
            ...|..:.|.|...|.|||:|.|....||          |.....:.:|.:| ::.:..:.:|.|
  Rat   701 GIYGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLL-IKHVVEEDSGYY 764

  Fly   265 QCTADNGVGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQ 329
            .|...|.||..|:..|.|.|..|..|....:...:.:|...::.|....:....|.|
  Rat   765 LCKVSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQRKEMSCTAHGEKPIIVRW-------- 821

  Fly   330 STDRRIMATRANRHMLTIRHIQQ-------------EDFGNYSCVADNSLGRSRKYMELSGR--- 378
            ..:.||:.....|::::.:.:.:             ||.|.:||.|.||.|..|..::|:.:
  Rat   822 EKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGEDRGIIQLTVQEPP 886

  Fly   379 -PGAAEFYSPK-------W-----GRSP------------DSY-------------NLTWKIDSY 405
             |...|....|       |     |.||            ||:             |....||.:
  Rat   887 DPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIH 951

  Fly   406 P----------------------------------PLEEVRL----------------------L 414
            |                                  |.:||.|                      :
  Rat   952 PSSTYSIRMYAKNRIGKSEPSNEITITADEAAPDGPPQEVHLEPTSSQSIRVTWKAPKKHLQNGI 1016

  Fly   415 YRRVQMN-ETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGWNEV 478
            .|..|:. ..|...|.:...|::.:....||      .||:.||:....|..:|||.||.|....
  Rat  1017 IRGYQIGYREYSTGGNFQFNIISIDTTGDSE------VYTLDNLNKFTQYGLVVQACNRAGTGPS 1075

  Fly   479 SDIFQFVVATNSQDI---GPEDAEVVASS--------KSRSNSASIGSLPGSTVLHTALLL 528
            |   |.::.|..:|:   .||:.:.:|:|        .:.|..|..|.|.|..|::.|.|:
  Rat  1076 S---QEIITTTLEDVPSYPPENVQAIATSPESISISWSTLSKEALNGILQGFRVIYWANLI 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	14/77 (18%)
		IG_like	109..195	CDD:214653	25/94 (27%)
		Ig	118..191	CDD:143165	21/75 (28%)
		IG_like	205..274	CDD:214653	19/78 (24%)
		IGc2	213..273	CDD:197706	18/69 (26%)
		IGc2	301..367	CDD:197706	15/78 (19%)
		FN3	392..486	CDD:238020	32/175 (18%)
Dscam	XP_038943864.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	125..210	CDD:416386
		Ig strand A	126..130	CDD:409353
		Ig strand A'	132..136	CDD:409353
		Ig strand B	139..149	CDD:409353
		Ig strand C	157..163	CDD:409353
		Ig strand C'	164..167	CDD:409353
		Ig strand E	179..185	CDD:409353
		Ig strand F	191..201	CDD:409353
		IGc2	239..300	CDD:197706
		Ig strand B	242..246	CDD:409353
		Ig strand C	255..259	CDD:409353
		Ig strand F	290..295	CDD:409353
		Ig	313..395	CDD:416386
		Ig strand A	314..319	CDD:409353
		Ig strand A'	322..326	CDD:409353
		Ig strand B	329..339	CDD:409353
		Ig strand C	344..350	CDD:409353
		Ig strand C'	351..354	CDD:409353
		Ig strand E	368..374	CDD:409353
		Ig strand F	381..389	CDD:409353
		Ig	406..501	CDD:416386	10/37 (27%)
		Ig strand A	406..409	CDD:409353
		Ig strand A'	415..419	CDD:409353
		Ig strand B	422..431	CDD:409353
		Ig strand C	436..442	CDD:409353
		Ig strand C'	444..447	CDD:409353
		Ig strand D	452..460	CDD:409353
		Ig strand E	464..473	CDD:409353	2/3 (67%)
		Ig strand F	480..488	CDD:409353	2/13 (15%)
		Ig strand G	491..501	CDD:409353	2/9 (22%)
		Ig	504..593	CDD:416386	13/97 (13%)
		Ig strand A	505..507	CDD:409353	0/1 (0%)
		Ig strand A'	512..516	CDD:409353	0/3 (0%)
		Ig strand B	519..526	CDD:409353	0/6 (0%)
		Ig strand C	533..539	CDD:409353	2/5 (40%)
		Ig strand C'	540..542	CDD:409353	0/1 (0%)
		Ig strand D	549..553	CDD:409353	0/10 (0%)
		Ig strand E	557..563	CDD:409353	1/7 (14%)
		Ig strand F	571..579	CDD:409353	0/7 (0%)
		Ig strand G	583..593	CDD:409353	1/9 (11%)
		Ig	596..686	CDD:416386	27/100 (27%)
		Ig strand A	597..599	CDD:409353	0/1 (0%)
		Ig strand B	611..620	CDD:409353	2/8 (25%)
		Ig strand C	625..632	CDD:409353	1/6 (17%)
		Ig strand C'	634..636	CDD:409353	0/1 (0%)
		Ig strand D	643..648	CDD:409353	3/8 (38%)
		Ig strand E	651..658	CDD:409353	2/6 (33%)
		Ig strand F	665..673	CDD:409353	4/12 (33%)
		Ig strand G	676..685	CDD:409353	2/8 (25%)
		Ig_DSCAM	689..784	CDD:409397	26/97 (27%)
		Ig strand B	707..711	CDD:409397	1/3 (33%)
		Ig strand C	720..724	CDD:409397	1/3 (33%)
		Ig strand E	749..753	CDD:409397	2/4 (50%)
		Ig strand F	763..768	CDD:409397	2/4 (50%)
		Ig strand G	777..780	CDD:409397	0/2 (0%)
Ig_DSCAM	785..884	CDD:409398	20/106 (19%)
Ig strand B	805..809	CDD:409398	0/3 (0%)
Ig strand C	818..822	CDD:409398	2/11 (18%)
Ig strand E	848..852	CDD:409398	0/3 (0%)
Ig strand F	862..867	CDD:409398	2/4 (50%)
Ig strand G	875..878	CDD:409398	1/2 (50%)
FN3	885..978	CDD:238020	13/92 (14%)
FN3	986..1083	CDD:238020	24/105 (23%)
FN3	1091..1184	CDD:238020	12/43 (28%)
FN3	1189..1278	CDD:238020
Ig_3	1287..1363	CDD:404760
Ig strand B	1303..1307	CDD:409353
Ig strand C	1316..1320	CDD:409353
Ig strand E	1342..1346	CDD:409353
Ig strand F	1356..1361	CDD:409353
FN3	1380..1470	CDD:238020
FN3	1486..1555	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900