DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment klg and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_524454.2	Gene:	klg / 42707	FlyBaseID:	FBgn0017590	Length:	545	Species:	Drosophila melanogaster
Sequence 2:	NP_473412.1	Gene:	Fgfrl1 / 116701	MGIID:	2150920	Length:	529	Species:	Mus musculus

Alignment Length:	601	Identity:	118/601 - (19%)
Similarity:	195/601 - (32%)	Gaps:	217/601 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PILIVISLGWLLHAHAGSGGFAVEAAISNRGSNSRSMSNVQQSAVAASTLTATLPRFLSRGHTYR 111
            |.|:::.||.|..|.|..|             ..|....|             :||.::|
Mouse     5 PALLLLLLGALPSAEAARG-------------PPRMADKV-------------VPRQVAR----- 38

  Fly   112 AVVGDTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRLIDGYN--------LEISDLE 168
              :|.|:.|.|.||.....:.:|              |:|.|. :..|::        |::.::|
Mouse    39 --LGRTVRLQCPVEGDPPPLTMW--------------TKDGRT-IHSGWSRFRVLPQGLKVKEVE 86

  Fly   169 PQDAGDYVCQISDKINRDQVHTVEIL---VPPSVRAIPTSG----------QLQARK-------- 212
            .:|||.|||:.::......|:...|:   :.|...:....|          |..||.
Mouse    87 AEDAGVYVCKATNGFGSLSVNYTLIIMDDISPGKESPGPGGSSGGQEDPASQQWARPRFTQPSKM 151

  Fly   213 ---------GGPITLECKGSGNPVPSIYWTK-----------KSGANKSTARIGDGPILTLEKLE 257
                     |..:.|:|..||:|.|.|.|.|           :....|.|        |:|:.|:
Mouse   152 RRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQTLTHLEASEHRKKKWT--------LSLKNLK 208

  Fly   258 RQQAGVYQCTADNGVGDPVTVDMRLDVL------------YPPDIQVEKSWIHSGEGFEAKLVCI 310
            .:.:|.|.|...|..| .:....::||:            :|.:..|:       .|......|.
Mouse   209 PEDSGKYTCRVSNKAG-AINATYKVDVIQRTRSKPVLTGTHPVNTTVD-------FGGTTSFQCK 265

  Fly   311 VFADPVATVSWYQNSFPIQSTDRRIMATRANRH-----------------------------MLT 346
            |.:|....:.|.          :|:......||                             .|.
Mouse   266 VRSDVKPVIQWL----------KRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSYLNKLL 320

  Fly   347 IRHIQQEDFGNYSCVADNSLGRSRKYMELSGRPGAAEFYSPKWGRSPDSYNLTWKIDSYPPLEEV 411
            |...:|:|.|.|.|:..|::|.|.:...|:..|.... ..|....|..|.:|.|.:....|...|
Mouse   321 ISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKP-PGPPMASSSSSTSLPWPVVIGIPAGAV 384

  Fly   412 RLLYR-RVQMNETYQQPGRWHDFILTPEHRPASEPLTHIMSYTIKNLHPGGYYEAIVQAKNRYGW 475
            .:|.. .:.:.:|.::|......:..|.|||                 ||       .::.|.|.
Mouse   385 FILGTVLLWLCQTKKKPCAPASTLPVPGHRP-----------------PG-------TSRERSGD 425

  Fly   476 NEVSDIF-------------QFVVATNSQDIGPE-------DAEVVASSKSRSNSASIGSLPGST 520
            .::..:.             |.::|:.| ..||:       |......:.:.:::.|.|....||
Mouse   426 KDLPSLAVGICEEHGSAMAPQHILASGS-TAGPKLYPKLYTDVHTHTHTHTCTHTLSCGGQGSST 489

  Fly   521 ------VLHTALLLAL 530
                  ||:||.|.||
Mouse   490 PACPLSVLNTANLQAL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	DUF1370	63..>124	CDD:284518	10/60 (17%)
		IG_like	109..195	CDD:214653	21/96 (22%)
		Ig	118..191	CDD:143165	18/80 (23%)
		IG_like	205..274	CDD:214653	23/106 (22%)
		IGc2	213..273	CDD:197706	19/70 (27%)
		IGc2	301..367	CDD:197706	16/94 (17%)
		FN3	392..486	CDD:238020	18/107 (17%)
Fgfrl1	NP_473412.1	I-set	29..112	CDD:369462	24/117 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..151		5/34 (15%)
		Ig2_FGFRL1-like	153..234	CDD:143264	20/89 (22%)
		Ig	257..351	CDD:386229	19/103 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000