Protein Alignment klg and ncam2

DIOPT Version :10

• Sequence 1: NP_524454.2
• Gene: klg / 42707
• FlyBaseID: FBgn0017590
• Length: 545
• Species: Drosophila melanogaster
• Sequence 2: XP_012811963.1
• Gene: ncam2 / 100151722
• XenbaseID: XB-GENE-1217730
• Length: 865
• Species: Xenopus tropicalis
• Alignment Length: 560
• Identity: 116/560 - (20%)
• Similarity: 213/560 - (38%)
• Gaps: 146/560 - (26%)

  Fly    94 STLTATLPRFLSRGHTYRAVVG--DTLVLPCQVENLGNFVLLWRRGTNVLTASNIMVTRDERVRL 156
            |.:....|..|::..::.|...  :.:.|.|:........:.|.|       :..:|..:|:..|
 Frog   231 SVIVNVPPEILAQQRSFNATADRLEDITLFCRATGSPKPYITWHR-------NGKLVEENEKYDL 288

  Fly   157 -IDGYNLEISDLEPQDAGDYVCQISDKIN-RDQVHTVEILVPPSVRAIPTSGQLQARKGGPITLE 219
             .|...|.:.::...|:|.|||:.::|.. .::...:::.|.|.:..:.....::   .|.:||.
 Frog   289 REDNTELTVKNIISTDSGLYVCRATNKAGFTEKQSFLQVFVQPHIVQLQNETTIE---HGHVTLT 350

  Fly   220 CKGSGNPVPSIYWTKKS-------------GANKSTARIGDGPILTLEKLERQQAGVYQCTADNG 271
            |:..|.|:|.|.|.:.|             |..:||...|... |.::.:....||.|.|.|.:.
 Frog   351 CEAEGEPIPEITWKRSSDGMIFYDGDKSQDGRIESTGHHGKSS-LHIKSVMLSDAGRYDCEAASR 414

  Fly   272 VGDPVTVDMRLDVLYPPDIQVEKSWIHSGEGFEAKLVCIVFADPVATVSWYQNSFPIQSTDRRIM 336
            :|.. ...|.|::.|.|.....::..:|.|.....:.|.|.::|.:::.|        |.|:.::
 Frog   415 IGGH-QKSMYLNIEYAPKFISNQTIYYSWENNPINISCDVTSNPPSSIYW--------SRDKLLL 470

  Fly   337 ATR----------ANRHMLTIRHIQQEDFGNYSCVADNSLG-RSRKY-MELSGRPGA-------- 381
            ..|          ..|.:|.|..:...|||.|:|.|.||:| |.::| :.|:..|.:
 Frog   471 PARNITNIKTYRDGKRILLEITPLSDNDFGRYNCTAINSIGSRIQEYILTLADVPSSPYGLRVIE 535

  Fly   382 -AEFYSPKWGRSPDS--------YNLTWKIDSYPPLEEVR-------LLYRRVQMNETYQ----- 425
             ::.|:..:...|||        |.:.:|..|....:.||       ::...:..|.||:
 Frog   536 LSQTYAKVFFNKPDSHGGVPIHHYQMDFKEVSSEIWKVVRSHGTQTIIVLGNLDANTTYEVKVAA 600

  Fly   426 ------------------------------QPGRWHDFIL--TPEHRPASEPLTHIMSYTIKN-- 456
                                          |||....|.|  |.:....:..|.:::.|..|:
 Frog   601 VNGKGKGEYSKTEIFQTLPVREPSPPSIHGQPGGGKSFKLSITKQDDGGAPILNYVVKYRSKDKE 665

  Fly   457 --------LHPGGY-----------YEAIVQAKNRYGWNEVSDIFQFVVATNSQDIGPEDAEVVA 502
                    |....|           ||..:.|.||.|.:|.: :|:|::        |....::|
 Frog   666 DQWLEKKFLGNKDYIILDHLQWNVGYEVHIIATNRLGHSEPT-VFEFLM--------PPKPNIIA 721

  Fly   503 SSKSRSNSASIGSLPGSTVLHTALLLALALS--NCQFDRR 540
            .  :..:...:|::.|..|  .||||.|.::  :|.|.|:
 Frog   722 D--TLFSGLGVGAVIGLAV--AALLLVLVVTDVSCFFIRQ 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
klg	NP_524454.2	IG_like	109..195	CDD:214653	16/89 (18%)
		Ig strand B	118..122	CDD:409353	1/3 (33%)
		Ig strand C	131..135	CDD:409353	0/3 (0%)
		Ig strand E	160..164	CDD:409353	1/3 (33%)
		Ig strand F	174..179	CDD:409353	3/4 (75%)
		Ig strand G	188..191	CDD:409353	0/2 (0%)
		Ig_3	196..270	CDD:464046	21/86 (24%)
		Ig_3	287..364	CDD:464046	19/86 (22%)
		FN3	392..486	CDD:238020	31/166 (19%)
ncam2	XP_012811963.1	Ig	50..142	CDD:472250
		Ig strand B	67..71	CDD:409452
		Ig strand C	79..83	CDD:409452
		Ig strand E	105..109	CDD:409452
		Ig strand F	119..124	CDD:409452
		Ig strand G	133..136	CDD:409452
		IG_like	150..234	CDD:214653	1/2 (50%)
		Ig strand B	161..165	CDD:409353
		Ig strand C	174..178	CDD:409353
		Ig strand E	198..202	CDD:409353
		Ig strand F	212..217	CDD:409353
		Ig	238..327	CDD:472250	18/95 (19%)
		Ig strand B	257..261	CDD:409301	1/3 (33%)
		Ig strand C	270..274	CDD:409301	0/3 (0%)
		Ig strand E	293..297	CDD:409301	1/3 (33%)
		Ig strand F	307..312	CDD:409301	3/4 (75%)
		Ig strand G	320..323	CDD:409301	0/2 (0%)
		Ig	329..426	CDD:472250	25/101 (25%)
		Ig strand B	347..351	CDD:143278	2/3 (67%)
		Ig strand C	360..364	CDD:143278	1/3 (33%)
		Ig strand E	392..396	CDD:143278	1/4 (25%)
		Ig strand F	406..411	CDD:143278	2/4 (50%)
		Ig strand G	419..422	CDD:143278	0/2 (0%)
		Ig_3	430..508	CDD:464046	19/85 (22%)
		FN3	525..617	CDD:238020	13/91 (14%)
		fn3	623..707	CDD:394996	18/83 (22%)