DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4704 and micu1

DIOPT Version :9

Sequence 1:	NP_001287476.1	Gene:	CG4704 / 42706	FlyBaseID:	FBgn0039029	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_005156578.1	Gene:	micu1 / 561210	ZFINID:	ZDB-GENE-070410-22	Length:	491	Species:	Danio rerio

Alignment Length:	380	Identity:	137/380 - (36%)
Similarity:	214/380 - (56%)	Gaps:	44/380 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQYENRLRLHAHPTKIFRYFATIKMKNKSGKWELYMTPNDFLRSIQPGLKQPENLGLDKFQILDE 65
            |:||||:|.::.|.||||||||:|:.|:.|..|:||||.||:|||.|..|||||||||:|.:...
Zfish   119 MEYENRIRAYSTPDKIFRYFATLKIINEHGDAEVYMTPQDFVRSITPNEKQPENLGLDQFMVKRY 183

  Fly    66 HAANKWIPE---------VKDDSIFLKIEKRGLLTYSDYVLLTILLSIPERNVRISFKLFDLNGD 121
            ...:.|..|         ..:||||..:.:.||:::|||:.||.:||.|:||..|:||:||||||
Zfish   184 DGKDFWQTEKISQDREKFADEDSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGD 248

  Fly   122 GDVTIDELDTVFMAMTQGEVSM------------------MNSHLKSHFFGHRLNKTLSIDEFLK 168
            |:|.::|.:.| .::.:.:.||                  .:|.|.::|||..|...|:|..||:
Zfish   249 GEVDLEEFEQV-QSIIRSQTSMGMRHRDRSTTGNTLKTGGCSSALTTYFFGADLKGKLTISSFLE 312

  Fly   169 FLHALHIEIHTDQFQNLLKESSSV---ISELDFAKVVLGLRKSRSER-REILKRVKKKFGQMDHG 229
            |...|..::...:|:    .:..|   |:|..|..::|.....:|.: :::.|.:|:.|... .|
Zfish   313 FQRKLQHDVLKLEFE----RNDPVDGRITEKQFGGMLLAYSGVQSRKLKQMQKNLKRMFKDA-QG 372

  Fly   230 ITLEEFLAFFRFVQDVSIMDNALAFYYFTGADISPKTMRHIAYVVTGVKLSQHLTDVIFCIFDRN 294
            ||.||...||.|:::|:.:|.||:||:..||.|...||:.:|..|..|:||.|:.||:|.:||.:
Zfish   373 ITFEEVENFFTFLKNVNDVDTALSFYHMAGASIDKATMKQVARTVAKVELSDHVCDVVFALFDCD 437

  Fly   295 NDNIIQRKEF-TDMRRQWMHPIPLRKNPKLLSKMCIVCKCTWKML--SAWNLREP 346
            .:..:..||| ..|:::.|..:   :.||.:....:| :..||..  :||:...|
Zfish   438 GNGELSNKEFIAIMKQRLMRGL---EKPKDMGFTRLV-RAMWKCAQDTAWDFAMP 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4704	NP_001287476.1	EFh	113..171	CDD:298682	25/75 (33%)
CG4704	NP_001287476.1	EF-hand_8	259..307	CDD:290545	19/48 (40%)
micu1	XP_005156578.1	PTPRCAP	29..>110	CDD:292341
		EF-hand_5	236..259	CDD:289945	12/22 (55%)
		EF-hand_8	401..454	CDD:290545	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586386
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	1	1.000	-	-		FOG0005802
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103708
Panther	1	1.100	-	-	O	PTHR12294
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.710