DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4704 and micu3a

DIOPT Version :9

Sequence 1:	NP_001287476.1	Gene:	CG4704 / 42706	FlyBaseID:	FBgn0039029	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_021326830.1	Gene:	micu3a / 559552	ZFINID:	ZDB-GENE-070713-1	Length:	544	Species:	Danio rerio

Alignment Length:	386	Identity:	98/386 - (25%)
Similarity:	165/386 - (42%)	Gaps:	101/386 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HAHPTKIFRYFATIKMKNKSGKWELYMTPNDFLRSI---QPGLKQPENLGLDKFQILDEHAANKW 71
            |.|.   ||.|::::.:.     :|||||.:|:.|:   :|.:|:|.. .|.|.::  |...:..
Zfish   151 HEHR---FRLFSSVEYEG-----QLYMTPQNFIESVTMSEPRIKKPWR-SLTKQEL--EKILSDT 204

  Fly    72 IPEVKDDS-IFLKIEKRGLLTYSDYVLLTILLSIPERNVRISFKLFDLNGDGDVTIDE-----LD 130
            .|..|..| :|..:.:||::.|::|:.|..:|:.|....:|:|.:||  .||:..:|:     |.
Zfish   205 PPVWKGTSKLFRNLRERGIIAYTEYLFLLCILTKPHAGFKIAFNMFD--ADGNQMVDKREFMVLQ 267

  Fly   131 TVF--------------------MAMTQGEVSMMNSHLKS------------------------- 150
            .:|                    |.:...:|:.:||.||.
Zfish   268 EIFRKKNEKKGRKGDAEKSAQLSMQLYGYQVAPVNSVLKKESQEFVPRSYWDKLRRGASQALFSD 332

  Fly   151 ----------------------HFFGHRLNKTLSIDEFLKFLHALHIEIHTDQFQNLLKESSSVI 193
                                  ||||.:....|:.|:|.:|:..|..|:...:|....| ..:.|
Zfish   333 LAEDFKLERADENMMIDTTLLVHFFGKKGKAELTFDDFYRFMDNLQTEMLEIEFLTYSK-GMTTI 396

  Fly   194 SELDFAKVVL------GLRKSRSERREILKRVKKKFGQMDHGITLEEFLAFFRFVQDVSIMDNAL 252
            ||.|||:::|      .:|......|:.:...||     ..|||.|||.:||:|:.::.....|:
Zfish   397 SEEDFARILLRYTNVEDIRSYLENVRQCIPDEKK-----PEGITFEEFRSFFQFLNNLEDFAIAM 456

  Fly   253 AFYYFTGADISPKTMRHIAYVVTGVKLSQHLTDVIFCIFDRNNDNIIQRKEFTDMRRQWMH 313
            ..|.|....|.........||.||:||::||.:.||.|||.::|:.:..|||..:.:..:|
Zfish   457 QMYNFACRSIGQDEFARAVYVATGLKLTRHLVNTIFKIFDVDHDDQLSYKEFIGIMKDRLH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4704	NP_001287476.1	EFh	113..171	CDD:298682	22/129 (17%)
CG4704	NP_001287476.1	EF-hand_8	259..307	CDD:290545	18/47 (38%)
micu3a	XP_021326830.1	HAD_like	138..>223	CDD:328728	23/82 (28%)
		EFh_MICU3	242..516	CDD:320083	68/281 (24%)
		EF-hand motif	242..271	CDD:320083	8/30 (27%)
		EF-hand motif	351..381	CDD:320083	9/29 (31%)
		EF-hand motif	450..479	CDD:320083	6/28 (21%)
		EF-hand motif	487..516	CDD:320083	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820