DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4704 and Micu1

DIOPT Version :9

Sequence 1:	NP_001287476.1	Gene:	CG4704 / 42706	FlyBaseID:	FBgn0039029	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_006256482.1	Gene:	Micu1 / 365567	RGDID:	735033	Length:	483	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	129/373 - (34%)
Similarity:	207/373 - (55%)	Gaps:	31/373 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQYENRLRLHAHPTKIFRYFATIKMKNKSGKWELYMTPNDFLRSIQPGLKQPENLGLDKFQILDE 65
            |:||||:|.::.|.||||||||:|:.|:.|:.|::|||.||:|||.|..||||:||||::.|...
  Rat   114 MEYENRIRAYSTPDKIFRYFATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRF 178

  Fly    66 HAANKWIPE---------VKDDSIFLKIEKRGLLTYSDYVLLTILLSIPERNVRISFKLFDLNGD 121
            .....|..|         ..:.|||..:.:.||:::|||:.||.:||.|:||..|:||:||||||
  Rat   179 DGKEFWQTEKIAQEREKFADEGSIFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGD 243

  Fly   122 GDVTIDELDTVFMAMTQGEVSMMNSH-----------------LKSHFFGHRLNKTLSIDEFLKF 169
            |:|.::|.:.| .::.:.:.||...|                 |.::|||..|...|:|..||:|
  Rat   244 GEVDMEEFEQV-QSIIRSQTSMGMRHRDRPTTGNTLKSGLCSALTTYFFGADLKGKLTIKNFLEF 307

  Fly   170 LHALHIEIHTDQFQNLLKESSSVISELDFAKVVLGLRKSRSERREILKRVKKKFGQMDHGITLEE 234
            ...|..::...:|:. .......|||..|..::|.....:|::...::|..||..:...|:|.:|
  Rat   308 QRKLQHDVLKLEFER-HDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQE 371

  Fly   235 FLAFFRFVQDVSIMDNALAFYYFTGADISPKTMRHIAYVVTGVKLSQHLTDVIFCIFDRNNDNII 299
            ...||.|:::::.:|.||:||:..||.:...||:.:|..|..|:||.|:.||:|.:||.:.:..:
  Rat   372 VENFFTFLKNINDVDTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGEL 436

  Fly   300 QRKEFTD-MRRQWMHPIPLRKNPKLLSKMCIVCKCTWKMLSAWNLREP 346
            ..|||.. |:::.|..:...|:......|..:.||..:  :||:...|
  Rat   437 SNKEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQE--TAWDFALP 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4704	NP_001287476.1	EFh	113..171	CDD:298682	25/74 (34%)
CG4704	NP_001287476.1	EF-hand_8	259..307	CDD:290545	18/48 (38%)
Micu1	XP_006256482.1	Acyl-thio_N	<41..>85	CDD:289367
Micu1	XP_006256482.1	EF-hand_5	231..254	CDD:289945	12/22 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	1	1.000	-	-		FOG0005802
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103708
Panther	1	1.100	-	-	O	PTHR12294
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750