DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4704 and MICU2

DIOPT Version :9

Sequence 1:	NP_001287476.1	Gene:	CG4704 / 42706	FlyBaseID:	FBgn0039029	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_689939.1	Gene:	MICU2 / 221154	HGNCID:	31830	Length:	434	Species:	Homo sapiens

Alignment Length:	333	Identity:	85/333 - (25%)
Similarity:	150/333 - (45%)	Gaps:	62/333 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FRYFATIKMKNKSGKWELYMTPNDFLRSIQPGLKQPENLGLDKFQILDEHAANKWI--PEVKD-- 77
            |..|::::.:.     |.||||.|||.|:.             |:.::...:.|.:  .:::|
Human    90 FMQFSSLEHEG-----EYYMTPRDFLFSVM-------------FEQMERKTSVKKLTKKDIEDTL 136

  Fly    78 ---------DSIFLKIEKRGLLTYSDYVLLTILLSIPERNVRISFKLFDLNGDGDVTI------- 126
                     .:.|..:..:||::|::|:.|..:|:.|.....::||:.|.  ||:..|
Human   137 SGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDT--DGNEMIEKREFFK 199

  Fly   127 --------DELDTVFMAMTQGEVSM-----MNSHLKSHFFGHRLNKTLSIDEFLKFLHALHIEIH 178
                    |:|.||....|..:.::     :|:.|:..|||.|..:.|...||.:|:..|..||.
Human   200 LQKIISKQDDLMTVKTNETGYQEAIVKEPEINTTLQMRFFGKRGQRKLHYKEFRRFMENLQTEIQ 264

  Fly   179 TDQFQNLLKESSSVISELDFAKVVLGLRKSRSERREIL-KRVKKKFGQMDHGITLEEFLAFFRFV 242
            ..:|....|..|.:..| |||:.:|..  :.:|.::|. |.|::|. .....|:|:||.:|..|.
Human   265 EMEFLQFSKGLSFMRKE-DFAEWLLFF--TNTENKDIYWKNVREKL-SAGESISLDEFKSFCHFT 325

  Fly   243 QDVSIMDNALAFYYFTGA--DISPKTMRHIAYVVTGVKLSQHLTDVIFCIFDRNNDNIIQRKEFT 305
              ..:.|.|:|...|:.|  .:.....:....|.||.:||.::.|.:|.|||.:.|..:..:||.
Human   326 --THLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHEEFL 388

  Fly   306 DMRRQWMH 313
            .:.:..||
Human   389 GVLKNRMH 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4704	NP_001287476.1	EFh	113..171	CDD:298682	21/77 (27%)
CG4704	NP_001287476.1	EF-hand_8	259..307	CDD:290545	14/49 (29%)
MICU2	NP_689939.1	EFh_MICU2	176..395	CDD:320082	61/226 (27%)
		EF-hand motif	176..205	CDD:320082	6/30 (20%)
		EF-hand motif	233..263	CDD:320082	10/29 (34%)
		EF-hand motif	329..358	CDD:320082	6/28 (21%)
		EF-hand motif	366..395	CDD:320082	8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820