Protein Alignment CG7029 and Rusc2

DIOPT Version :10

• Sequence 1: NP_788719.1
• Gene: CG7029 / 42703
• FlyBaseID: FBgn0039026
• Length: 1744
• Species: Drosophila melanogaster
• Sequence 2: NP_951012.2
• Gene: Rusc2 / 100213
• MGIID: 2140371
• Length: 1523
• Species: Mus musculus
• Alignment Length: 1636
• Identity: 303/1636 - (18%)
• Similarity: 482/1636 - (29%)
• Gaps: 622/1636 - (38%)

  Fly   502 CGGGGGGGVGMR---------------ETTNGGGNNLNCSLASSHDFTHDNSDYQWFLDYGYRDG 551
            |||.||||.|.|               .......:.|..||.|:......:||   .:....|||
Mouse    38 CGGAGGGGGGTRANPFCPPELGLTQPDHDLGQADSLLYPSLHSAPGAPTGSSD---SVKSRSRDG 99

  Fly   552 CG----GMQRSVLSSLSASYNAMGDLIYYEDLAKNLDANLAE-VDMESFRAEDIHSLLS--HL-- 607
            .|    ......|.........:|||         .|::..: |..:||.   :||...  ||
Mouse   100 RGPGAPKRHNPFLVQEGVGETGLGDL---------HDSSTGDSVTQQSFH---LHSASQPFHLSS 152

  Fly   608 -------PAYCKSLGGTNSRLQQSLLLQQQQ---------------------------------- 631
                   |...:..|.|:||  ..::..|:|
Mouse   153 FQLPPSGPGQGRPWGATHSR--PGVVEGQEQDPATALGTQCSTSHCCRPELEAERMELDECGGHG 215

  Fly   632 ----------------QQQQQLQQQQVLQH----NSMLQHMSQTSTTSTNELIDNSF-------C 669
                            :|:.::...:..:|    .|..||...:||:|.:|..|.|.       |
Mouse   216 GSGSGGGTSDISGFSFEQEWKISSDESPRHPGRSGSGTQHCHCSSTSSQSEAADQSMGYVSDSSC 280

  Fly   670 KSE----LLFSPVRESHISVDSLDMDAYPDDGEIILTCNKDNYTIAFEGSVLYSD-DSFYADPSD 729
            .|.    :.||.:.....|....::::.|.      :|:..::       ..::| .:||.|...
Mouse   281 NSSDGVLVTFSTLYNKMHSSSRANLNSVPQ------SCSDSSF-------CSHADPGAFYLDLQP 332

  Fly   730 IAARNKQNCINLHSNLEDIVKRNKALEVS---MSRSAQAFQP---LCPMSPKGQAATTSAAKLQR 788
            ..|.::.:|.:.|....|..:......||   :..:..|:.|   .||      |.....|..|.
Mouse   333 SPAESRMSCESHHPENGDREEGCGCPHVSSPELDANCNAYHPHSEPCP------AVADLTACFQS 391

  Fly   789 RSLFLVSPARRY------------PSGNNNTETITITRH---------LPQCTVRKSSSL----- 827
            ::..:|:....|            ||...::.|.....|         .|.....:.|..
Mouse   392 QARLVVATQNYYKLVTCDLSSQSSPSPAGSSITSCSEEHTKISPPPGPCPDPDPNQPSEYYLFQK 456

  Fly   828 PNLQNEEAMA-GSCHKEQGPEES----GPQAVPLNVSQAISTSTMEAGKSRSRNL---------- 877
            |::|.||..| ||      |.|:    ||..:...|....|...:..|:.|||:.
Mouse   457 PDIQPEEQEAVGS------PAEAATAMGPTVLEGQVYTNTSPPNLNTGRQRSRSYDRSLERSPPV 515

  Fly   878 -LPMCQMPISISVSISERLQQQADQQLPSEQITPTSQQPQQQHHHSHHHRHKHRCSCSQESHISG 941
             |...:..:|..|.:||.....|....|..::|..::..:                        |
Mouse   516 RLGSLERMLSCPVRLSEGPAALAGPASPPRRVTSFAELAK------------------------G 556

  Fly   942 SASSGNSSNPPAFNLVKLFIKQKSSNSSGGQE---------DLGAQASAHTCMDVSSGCWPSSD- 996
            ...:..|.:||    ::..:...|...|..||         |.|.:.| |:...:..|  ||.|
Mouse   557 RKKAAGSGSPP----LRASVGDSSQEFSPIQEAQQDRAAPLDEGTRCS-HSLPSLPLG--PSLDL 614

  Fly   997 ------AASSSSGSLEQRLRKKSMNDSGKGSAVSRHDEEEHY---PDTETPRRQLRARSEAVFYD 1052
                  :.....||....:...|:..:|:|......|....:   |.|...:|..|||
Mouse   615 LGPEPWSTPVCQGSQSSEMPLPSLRAAGQGPLAQLMDPGPAFSGSPATSHTQRDSRAR------- 672

  Fly  1053 DVASSSSTGSLTATN-SPAHRRRSMPLRN--------------------PQLYQLAAQVSTGSQ- 1095
              |....|.|..... |...|..::|::.                    .|||.|:...|...|
Mouse   673 --ADGGGTESRPVLRYSKEQRPTTLPIQPFVFQHHFPKQLAKARALHSLSQLYSLSMPCSRAQQP 735

  Fly  1096 ---------------------MSSEASSEQLTQV----------------PRRAEAGCGTSTRPL 1123
                                 .:|:||.......                |.|:....|:||.
Mouse   736 APLVISTAQGPAPAPSGEPQPFTSQASGRGARNAGPEPETSRPSPLGSYSPVRSAGPFGSSTD-- 798

  Fly  1124 SCASSSEMITRSMQTSCGSLS--------TTRSSLSDRYRCVPPSFLEKLNNLGEERQAPIYVIY 1180
            |.||:|........|:..|:|        |.|.:.|.:    ||...:|:..|.|      |.::
Mouse   799 SSASTSCSPPPEQGTAADSVSPWSHTCPPTVRPATSQQ----PPKEDQKIPTLAE------YRLH 853

  Fly  1181 PNYALPDLGFVKTNASTDVIFSPFNYKMTMDGATGSTS-----SSGSLRKQRNSSQSVSEDEILK 1240
            ...:||.||..::                  |.|.:.|     ..||:..:.|::..:| .:.||
Mouse   854 GTGSLPPLGSWRS------------------GFTRAESLVRGGGEGSMANRPNNANHLS-PQALK 899

  Fly  1241 TLDYKHVADWQSLATLLPSEYRRRL------------QHIPEVK------------------HLV 1275
                     |:        ||||:.            :..||.:                  ||.
Mouse   900 ---------WR--------EYRRKNPLGPPGLSGSLDRRPPEARLARRNPIFEFPGSFGTTSHLN 947

  Fly  1276 RQLDAELSQRPLFCMSPPLR-------RNRTHICDCAKYFQGQQTQTDEASSSGSSQQPSSGYRG 1333
            .:|:.::| :||....|.|:       :.....|               .|..|:|:..|.....
Mouse   948 CRLNGQIS-KPLSLTCPDLQDPFSLTEKPPAEFC---------------LSPDGNSEAISIDILQ 996

  Fly  1334 SSTLLTDSELDVDPLKQMYVYQYDQQRMDSGVETSPGSQLTQTPPQ----------PMPRSILRK 1388
            ...|:......||    :.|..:...| |.||:...|:  :...|.          |..:::|..
Mouse   997 KKGLVKAVNTAVD----LIVAHFGTSR-DPGVKAKLGN--SSVSPNVGHLVLKYLCPAVQAVLED 1054

  Fly  1389 AHSA--------QSRSKRNSMIEAQQTQKLTKLEKRRSLQEPPNNYGL-GSTDELADVFEEEEHS 1444
            ...|        |.::...|::||             |.|..|:...| |..::::...|...|:
Mouse  1055 GLKAFVLDVIIGQRKNMPWSVVEA-------------STQLGPSTKVLHGLYNKVSQFPELTSHT 1106

  Fly  1445 QPAPPVKQRLSRKDLDARARAESFLASLPRSELKYYAEIASILESSGEHVTYDAAALKKEVSRVL 1509
            .                  |..:|:..|        ..|.| ||....|:
Mouse  1107 M------------------RFNAFILGL--------LNIRS-LEFWFNHL--------------- 1129

  Fly  1510 SQQKKVSFNDEGVAAGLQQHAKRFATPPNSPNISMG------------ALKRDTVDVL-EQRKIE 1561
                   :|.|.:   :|.|.:.:.....:..:..|            ||...::|:| :.|.::
Mouse  1130 -------YNHEDI---IQTHYQPWGFLRAAHTVCPGLFEELLLLLQPLALLPFSLDLLFQHRLLQ 1184

  Fly  1562 SNRFKR-----LQIQWELMSKDSSML-----------------------------------KELA 1586
            |.|.:|     |::..:|:....|.|                                   :|.|
Mouse  1185 SGRQQRQHKELLRVSQDLLLSAHSTLQLARSRGQEGPGDMDRVAPGERVKGVGASEGGEEDEEDA 1249

  Fly  1587 SEAATKSGGSTP---TSGNSTG-------------SNSAPRSRIPRPVSYPAGRSSTPTS--SRT 1633
            .|.|..:|.|..   ..|...|             ..:|..||.||..|..:|..|....  ...
Mouse  1250 EEVAVVAGSSDHGKWARGGQAGWWYQLMQSSQVYIDGTAEGSRFPRSSSSSSGSGSEKKKGVGSG 1314

  Fly  1634 APVLATPSPAR----------PATPKTVTKSHNKPGLFTSPRPS---RLTSAQEAAG------GN 1679
            .|..|.|.|.|          ||..:.:.:....|....||..|   .|..::|..|      .|
Mouse  1315 GPSQAPPPPPREGVVEGAEACPAPEEALGQERGWPFWMGSPPDSVLAELRRSREREGPVAPPTEN 1379

  Fly  1680 KVSTRSPSRIVQP---KRYSLAGATTPTSTTPTSARARTPTNRVAVTAPNTPKR--QAVAQS--- 1736
            :..|..||    |   |...|.|:.       .|.|...||||:.....:..|.  |.|||:
Mouse  1380 EEGTAEPS----PGGIKWGHLFGSR-------KSQREARPTNRLPSDWLSLDKSVFQLVAQTMGA 1433

  Fly  1737 ---PRPTSRVR 1744
               |.|...::
Mouse  1434 RREPEPRENLQ 1444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7029	NP_788719.1	PHA03247	<1590..1739	CDD:223021	47/196 (24%)
Rusc2	NP_951012.2	PHA03247	<534..929	CDD:223021	87/482 (18%)
		RUN_RUSC2	996..1155	CDD:439064	36/230 (16%)
		SH3	1458..1509	CDD:473055