Protein Alignment Usp12-46 and UBP1

DIOPT Version :10

• Sequence 1: NP_651099.1
• Gene: Usp12-46 / 42702
• FlyBaseID: FBgn0039025
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_010161.1
• Gene: UBP1 / 851435
• SGDID: S000002280
• Length: 809
• Species: Saccharomyces cerevisiae
• Alignment Length: 679
• Identity: 124/679 - (18%)
• Similarity: 185/679 - (27%)
• Gaps: 326/679 - (48%)

  Fly    25 GLVNFGNTCYSNSVLQALYFCKPFRE--------------------------------------- 50
            ||||.||||:.|||||:|...:...|
Yeast   102 GLVNDGNTCFMNSVLQSLASSRELMEFLDNNVIRTYEEIEQNEHNEEGNGQESAQDEATHKKNTR 166

  Fly    51 ----------KVLEYKAKNKRPKE--------------TLLSCLADLFYSIATQKK-----KVGS 86
                      |.|..|:.:|..:|              .|||.|...:|......|     |..|
Yeast   167 KGGKVYGKHKKKLNRKSSSKEDEEKSQEPDITFSVALRDLLSALNAKYYRDKPYFKTNSLLKAMS 231

  Fly    87 IAPKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAERNAGPSNGNPKATNQGGSTSAM 151
            .:|:|.|..         .|.|:||.||.        :.||||..:     |.|:.|    |..:
Yeast   232 KSPRKNILL---------GYDQEDAQEFF--------QNILAELES-----NVKSLN----TEKL 270

  Fly   152 ASSIASKS----------------------------SSTSNSNSNSNST-----TNSNGNSSNST 183
            .::..:||                            :|..:..|..|.|     |..:|.::...
Yeast   271 DTTPVAKSELPDDALVGQLNLGEVGTVYIPTEQIDPNSILHDKSIQNFTPFKLMTPLDGITAERI 335

  Fly   184 GSL---------------------NANT-SVLDASGSLTATTTP-IISG---NGTGTNGANS--- 219
            |.|                     |.|. |.|..|..|:..:.| ||.|   |......|:|
Yeast   336 GCLQCGENGGIRYSVFSGLSLNLPNENIGSTLKLSQLLSDWSKPEIIEGVECNRCALTAAHSHLF 400

  Fly   220 ----------EPTWVHEIFQGILTSETRCLNCETVSSK----DENFFDLQ--------------- 255
                      |.:...::...:   :.|....|.|.:|    ||::..|.
Yeast   401 GQLKEFEKKPEGSIPEKLINAV---KDRVHQIEEVLAKPVIDDEDYKKLHTANMVRKCSKSKQIL 462

  Fly   256 -------VDVDQNTSI----THCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPM---- 305
                   :.:..|.|:    |:.:| .:|::.|..........||...|.....|   |||
Yeast   463 ISRPPPLLSIHINRSVFDPRTYMIR-KNNSKVLFKSRLNLAPWCCDINEINLDAR---LPMSKKE 523

  Fly   306 -----------------ILALHLKRFK------------------YMEQFNRHIK---------- 325
                             ...|| :||:                  |...:| |.|
Yeast   524 KAAQQDSSEDENIGGEYYTKLH-ERFEQEFEDSEEEKEYDDAEGNYASHYN-HTKDISNYDPLNG 586

  Fly   326 -----------------------VSHRVVFPLELRLFNTSD-------DAVNPDR---------- 350
                                   :..|::...::...|..|       |.|:.|.
Yeast   587 EVDGVTSDDEDEYIEETDALGNTIKKRIIEHSDVENENVKDNEELQEIDNVSLDEPKINVEDQLE 651

  Fly   351 ----------------------------LYDLTAVVIHCGSGPNRGHYISIVKSHGLWLLFDDD- 386
                                        .|.|.:|::|.|: .|.||||:..|..|.|....|:
Yeast   652 TSSDEEDVIPAPPINYARSFSTVPATPLTYSLRSVIVHYGT-HNYGHYIAFRKYRGCWWRISDET 715

  Fly   387 --MVDKIEASTIEDFYGLTSDIHKSSETG 413
              :||:.|..:....:.|..:.....|||
Yeast   716 VYVVDEAEVLSTPGVFMLFYEYDFDEETG 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp12-46	NP_651099.1	Peptidase_C19G	25..419	CDD:239128	124/679 (18%)
UBP1	NP_010161.1	Peptidase_C19	101..>293	CDD:470612	47/216 (22%)
		Peptidase_C19F	102..736	CDD:239127	121/669 (18%)
		Peptidase_C19	<427..>510	CDD:470612	14/83 (17%)