Protein Alignment Usp12-46 and USP38

DIOPT Version :9

• Sequence 1: NP_651099.1
• Gene: Usp12-46 / 42702
• FlyBaseID: FBgn0039025
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_115946.2
• Gene: USP38 / 84640
• HGNCID: 20067
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 572
• Identity: 126/572 - (22%)
• Similarity: 191/572 - (33%)
• Gaps: 243/572 - (42%)

  Fly    25 GLVNFGNTCYSNSVLQALYFCKPFREKVLEYKAKNKRPKETLLSCLADLFYSIA-TQKKKVGSIA 88
            ||:|.|||||.|||:|||:....||.:||   :.|.....:|:..|..||..:| ||::   :.|
Human   446 GLINLGNTCYMNSVIQALFMATDFRRQVL---SLNLNGCNSLMKKLQHLFAFLAHTQRE---AYA 504

  Fly    89 PKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINE---IILAERNAGPSNGNPKATNQGGSTSA 150
            |:.|....|  ...|....|||..|:|.||::.::|   |:..:.:..||.     ..:...||
Human   505 PRIFFEASR--PPWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSE-----ILECSETS- 561

  Fly   151 MASSIASKSSSTSNSNSNSNSTTNSNGNSSNSTGSLNANTSVLDASGSLTATTTPIISGNGTGTN 215
             ...:|||::                                       ..|.||..|
Human   562 -LQEVASKAA---------------------------------------VLTETPRTS------- 579

  Fly   216 GANSEPTWVHEIFQGILTSETRCLNCETVSSKDENFFDLQV------------------------ 256
              :.|.|.:.::|.|.|.:..|||||.:.|.|.|.|.||.:
Human   580 --DGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQD 642

  Fly   257 --------------------------------------------------------------DVD 259
                                                                          ||.
Human   643 GGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVP 707

  Fly   260 Q------NTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYME 318
            |      ..|:|..|..|...|.|..||::.|:||.|.|.|:|.|::.:.|..|.|.|.||.|.:
Human   708 QKPGGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQ 772

  Fly   319 QFNRHIKVSHRVVFPLELRL-------FNTSDDAVNPD-------------------------RL 351
            :::...|:...|..||.|.|       |::..::.:.|                         :|
Human   773 KYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKL 837

  Fly   352 --YDLTAVVIHCGSGPNRGHYISIVK------------------------SHGL----------- 379
              |.|::||:|.|.....|||.|..:                        ||.|
Human   838 VPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVFEQ 902

  Fly   380 ----------WLLFDDDMVDKIEASTIEDFYGLTSDIHKSSETGYILFYQSR 421
                      |.||:|   .::..::.:....:||...|  :|.|:|.|:.:
Human   903 DLENKEMSKEWFLFND---SRVTFTSFQSVQKITSRFPK--DTAYVLLYKKQ 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp12-46	NP_651099.1	Peptidase_C19G	25..419	CDD:239128	125/568 (22%)
USP38	NP_115946.2	Peptidase_C19H	446..947	CDD:239129	125/568 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810