DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp12-46 and Usp46

DIOPT Version :9

Sequence 1:	NP_651099.1	Gene:	Usp12-46 / 42702	FlyBaseID:	FBgn0039025	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	NP_808229.1	Gene:	Usp46 / 69727	MGIID:	1916977	Length:	366	Species:	Mus musculus

Alignment Length:	422	Identity:	267/422 - (63%)
Similarity:	303/422 - (71%)	Gaps:	67/422 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGANVSQLEREIGSDLFPPNEHYFGLVNFGNTCYSNSVLQALYFCKPFREKVLEYKAKNKRPKET 65
            ||.|.|.||::||.:.||.|||||||||||||||.||||||||||:||||.||.|||:.|: ||.
Mouse    12 MGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK-KEN 75

  Fly    66 LLSCLADLFYSIATQKKKVGSIAPKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAER 130
            ||:||||||:||||||||||.|.|||||:|||||.:.||||||||||||||:|:|.|.:|:..|:
Mouse    76 LLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEK 140

  Fly   131 NAGPSNGNPKATNQGGSTSAMASSIASKSSSTSNSNSNSNSTTNSNGNSSNSTGSLNANTSVLDA 195
            .....||..|                         |.|.|....:|
Mouse   141 KQEKQNGKLK-------------------------NGNMNEPAENN------------------- 161

  Fly   196 SGSLTATTTPIISGNGTGTNGANSEPTWVHEIFQGILTSETRCLNCETVSSKDENFFDLQVDVDQ 260
                                  ..|.|||||||||.||:|||||||||||||||:|.||.|||:|
Mouse   162 ----------------------KPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQ 204

  Fly   261 NTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYMEQFNRHIK 325
            |||||||||.|||||||||:.|:.|:.|||.||||||||||||||||||||||||||||.:|:.|
Mouse   205 NTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTK 269

  Fly   326 VSHRVVFPLELRLFNTSDDAVNPDRLYDLTAVVIHCGSGPNRGHYISIVKSHGLWLLFDDDMVDK 390
            :|:||||||||||||||.||||.||:|||.|||:||||||||||||:||||||.|||||||:|:|
Mouse   270 LSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEK 334

  Fly   391 IEASTIEDFYGLTSDIHKSSETGYILFYQSRD 422
            |:|..||:||||||||.|:||:|||||||||:
Mouse   335 IDAQAIEEFYGLTSDISKNSESGYILFYQSRE 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp12-46	NP_651099.1	Peptidase_C19G	25..419	CDD:239128	248/393 (63%)
Usp46	NP_808229.1	Peptidase_C19G	36..363	CDD:239128	248/393 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836668
Domainoid	1	1.000	431	1.000	Domainoid score	I580
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56957
Inparanoid	1	1.050	472	1.000	Inparanoid score	I1492
Isobase	1	0.950	-	0	Normalized mean entropy	S1113
OMA	1	1.010	-	-		QHG54027
OrthoDB	1	1.010	-	-		D378361at2759
OrthoFinder	1	1.000	-	-		FOG0001354
OrthoInspector	1	1.000	-	-		otm42909
orthoMCL	1	0.900	-	-		OOG6_101733
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2327
SonicParanoid	1	1.000	-	-		X844
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750