Protein Alignment Usp12-46 and USP46

DIOPT Version :9

• Sequence 1: NP_651099.1
• Gene: Usp12-46 / 42702
• FlyBaseID: FBgn0039025
• Length: 424
• Species: Drosophila melanogaster
• Sequence 2: NP_073743.2
• Gene: USP46 / 64854
• HGNCID: 20075
• Length: 366
• Species: Homo sapiens
• Alignment Length: 422
• Identity: 267/422 - (63%)
• Similarity: 303/422 - (71%)
• Gaps: 67/422 - (15%)

  Fly     1 MGANVSQLEREIGSDLFPPNEHYFGLVNFGNTCYSNSVLQALYFCKPFREKVLEYKAKNKRPKET 65
            ||.|.|.||::||.:.||.|||||||||||||||.||||||||||:||||.||.|||:.|: ||.
Human    12 MGTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK-KEN 75

  Fly    66 LLSCLADLFYSIATQKKKVGSIAPKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAER 130
            ||:||||||:||||||||||.|.|||||:|||||.:.||||||||||||||:|:|.|.:|:..|:
Human    76 LLTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEK 140

  Fly   131 NAGPSNGNPKATNQGGSTSAMASSIASKSSSTSNSNSNSNSTTNSNGNSSNSTGSLNANTSVLDA 195
            .....||..|                         |.|.|....:|
Human   141 KQEKQNGKLK-------------------------NGNMNEPAENN------------------- 161

  Fly   196 SGSLTATTTPIISGNGTGTNGANSEPTWVHEIFQGILTSETRCLNCETVSSKDENFFDLQVDVDQ 260
                                  ..|.|||||||||.||:|||||||||||||||:|.||.|||:|
Human   162 ----------------------KPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQ 204

  Fly   261 NTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYMEQFNRHIK 325
            |||||||||.|||||||||:.|:.|:.|||.||||||||||||||||||||||||||||.:|:.|
Human   205 NTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTK 269

  Fly   326 VSHRVVFPLELRLFNTSDDAVNPDRLYDLTAVVIHCGSGPNRGHYISIVKSHGLWLLFDDDMVDK 390
            :|:||||||||||||||.||||.||:|||.|||:||||||||||||:||||||.|||||||:|:|
Human   270 LSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEK 334

  Fly   391 IEASTIEDFYGLTSDIHKSSETGYILFYQSRD 422
            |:|..||:||||||||.|:||:|||||||||:
Human   335 IDAQAIEEFYGLTSDISKNSESGYILFYQSRE 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp12-46	NP_651099.1	Peptidase_C19G	25..419	CDD:239128	248/393 (63%)
USP46	NP_073743.2	Peptidase_C19G	36..363	CDD:239128	248/393 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146566
Domainoid	1	1.000	420	1.000	Domainoid score	I637
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56957
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1573
Isobase	1	0.950	-	0	Normalized mean entropy	S1113
OMA	1	1.010	-	-		QHG54027
OrthoDB	1	1.010	-	-		D378361at2759
OrthoFinder	1	1.000	-	-		FOG0001354
OrthoInspector	1	1.000	-	-		otm40835
orthoMCL	1	0.900	-	-		OOG6_101733
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2327
SonicParanoid	1	1.000	-	-		X844
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750