DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp12-46 and usp12b

DIOPT Version :9

Sequence 1:	NP_651099.1	Gene:	Usp12-46 / 42702	FlyBaseID:	FBgn0039025	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_688359.3	Gene:	usp12b / 559878	ZFINID:	ZDB-GENE-100209-4	Length:	383	Species:	Danio rerio

Alignment Length:	422	Identity:	273/422 - (64%)
Similarity:	308/422 - (72%)	Gaps:	54/422 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGANVSQLEREIGSDLFPPNEHYFGLVNFGNTCYSNSVLQALYFCKPFREKVLEYKAKNKRPKET 65
            ||||.|.||:|||.:.||.|||||||||||||||.||||||||||:|||||||.||.:.:| ||:
Zfish    16 MGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKIQPRR-KES 79

  Fly    66 LLSCLADLFYSIATQKKKVGSIAPKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAER 130
            ||:||||||.||||||||||.|.|||||:|||||.|.||||||||||||||:|:|.|.: :|.|.
Zfish    80 LLTCLADLFNSIATQKKKVGVIPPKKFISRLRKENELFDNYMQQDAHEFLNYLLNTIAD-LLQEE 143

  Fly   131 NAGPSNGNPKATNQGGSTSAMASSIASKSSSTSNSNSNSNSTTNSNGNSSNSTGSLNANTSVLDA 195
            .:.....|.|....|||.|                         ..|.|.:|||.
Zfish   144 KSQERQQNGKVVQNGGSGS-------------------------GGGGSGSSTGE---------- 173

  Fly   196 SGSLTATTTPIISGNGTGTNGANSEPTWVHEIFQGILTSETRCLNCETVSSKDENFFDLQVDVDQ 260
                             |.....::.|||||||||.||:||||||||.||||||:|.||.|||:|
Zfish   174 -----------------GETEEKTQQTWVHEIFQGTLTNETRCLNCEAVSSKDEDFLDLSVDVEQ 221

  Fly   261 NTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYMEQFNRHIK 325
            |||||||||.|||||||||:.|:.|:.|.|.||||||||||||||||||||||||||:|.:|:.|
Zfish   222 NTSITHCLRGFSNTETLCSEYKYYCEQCRSKQEAQKRMRVKKLPMILALHLKRFKYMDQLHRYTK 286

  Fly   326 VSHRVVFPLELRLFNTSDDAVNPDRLYDLTAVVIHCGSGPNRGHYISIVKSHGLWLLFDDDMVDK 390
            :|:||||||||||||||.||.||||||||.|||:||||||||||||:||||||.|||||||:|:|
Zfish   287 LSYRVVFPLELRLFNTSGDATNPDRLYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVEK 351

  Fly   391 IEASTIEDFYGLTSDIHKSSETGYILFYQSRD 422
            |:|..||:||||||||.|:||:||||||||||
Zfish   352 IDAQAIEEFYGLTSDISKNSESGYILFYQSRD 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp12-46	NP_651099.1	Peptidase_C19G	25..419	CDD:239128	251/393 (64%)
usp12b	XP_688359.3	UCH	38..379	CDD:278850	252/394 (64%)
usp12b	XP_688359.3	Peptidase_C19G	40..380	CDD:239128	251/393 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580198
Domainoid	1	1.000	486	1.000	Domainoid score	I379
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1196
OMA	1	1.010	-	-		QHG54027
OrthoDB	1	1.010	-	-		D378361at2759
OrthoFinder	1	1.000	-	-		FOG0001354
OrthoInspector	1	1.000	-	-		otm24593
orthoMCL	1	0.900	-	-		OOG6_101733
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2327
SonicParanoid	1	1.000	-	-		X844
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800