DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp12-46 and Usp46

DIOPT Version :9

Sequence 1:	NP_651099.1	Gene:	Usp12-46 / 42702	FlyBaseID:	FBgn0039025	Length:	424	Species:	Drosophila melanogaster
Sequence 2:	XP_006250950.1	Gene:	Usp46 / 289584	RGDID:	1564808	Length:	406	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	267/423 - (63%)
Similarity:	304/423 - (71%)	Gaps:	71/423 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GANVSQLEREIGSDLFPPNEHYFGLVNFGNTCYSNSVLQALYFCKPFREKVLEYKAKNKRPKETL 66
            |.|.|.||::||.:.||.|||||||||||||||.||||||||||:||||.||.|||:.|: ||.|
  Rat    53 GTNASALEKDIGPEQFPINEHYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK-KENL 116

  Fly    67 LSCLADLFYSIATQKKKVGSIAPKKFITRLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAERN 131
            |:||||||:||||||||||.|.|||||:|||||.:.||||||||||||||:|:|.|.:|:..|:.
  Rat   117 LTCLADLFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKK 181

  Fly   132 AGPSNGNPKATNQGGSTSAMASSIASKSSSTSNSNSNSNSTTNSNGNSSNSTGSLNANTSVLDAS 196
            ....||..|                                   |||.:..
  Rat   182 QEKQNGKLK-----------------------------------NGNMNEP-------------- 197

  Fly   197 GSLTATTTPIISGNGTGTNGANSEP--TWVHEIFQGILTSETRCLNCETVSSKDENFFDLQVDVD 259
                               ..||:|  |||||||||.||:|||||||||||||||:|.||.|||:
  Rat   198 -------------------AENSKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVE 243

  Fly   260 QNTSITHCLRCFSNTETLCSDNKFKCDNCCSYQEAQKRMRVKKLPMILALHLKRFKYMEQFNRHI 324
            ||||||||||.|||||||||:.|:.|:.|||.||||||||||||||||||||||||||||.:|:.
  Rat   244 QNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYT 308

  Fly   325 KVSHRVVFPLELRLFNTSDDAVNPDRLYDLTAVVIHCGSGPNRGHYISIVKSHGLWLLFDDDMVD 389
            |:|:||||||||||||||.||||.||:|||.|||:||||||||||||:||||||.|||||||:|:
  Rat   309 KLSYRVVFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVKSHGFWLLFDDDIVE 373

  Fly   390 KIEASTIEDFYGLTSDIHKSSETGYILFYQSRD 422
            ||:|..||:||||||||.|:||:|||||||||:
  Rat   374 KIDAQAIEEFYGLTSDISKNSESGYILFYQSRE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp12-46	NP_651099.1	Peptidase_C19G	25..419	CDD:239128	249/395 (63%)
Usp46	XP_006250950.1	UCH	74..402	CDD:278850	250/396 (63%)
Usp46	XP_006250950.1	Peptidase_C19G	76..403	CDD:239128	249/395 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340369
Domainoid	1	1.000	368	1.000	Domainoid score	I886
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56957
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1846
OMA	1	1.010	-	-		QHG54027
OrthoDB	1	1.010	-	-		D378361at2759
OrthoFinder	1	1.000	-	-		FOG0001354
OrthoInspector	1	1.000	-	-		otm44979
orthoMCL	1	0.900	-	-		OOG6_101733
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X844
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770