DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and ECE2

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	749	Identity:	177/749 - (23%)
Similarity:	315/749 - (42%)	Gaps:	121/749 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLGAILFSICAIDASVPHPLAANYSIDILR--LAKAAHIKAYMGDEKEQACNNFYNYACANWPR 70
            |||.|:|.. |.:...|.:....::|..:..  :..|..|...: |.....|.:||.::|..|.|
Human   114 LLLAALLLG-CLVALGVQYHRDPSHSTCLTEACIRVAGKILESL-DRGVSPCEDFYQFSCGGWIR 176

  Fly    71 LHPARKSKTRTNYLEEL--QELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTNDTRSALN 133
            .:|....::|.|....|  |...|.|  .:|::.|..:.:.|:::.:.||.||............
Human   177 RNPLPDGRSRWNTFNSLWDQNQAILK--HLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQ 239

  Fly   134 TLQNVTDFRGGWPEIRVASWYQYEY-DWLQVVANLKRKLGVDIFIGLEVILDYKEEKMHRLKIG- 196
            .|:::.:..|||.  ....|.|..: :.|:.||...|   ...|..:.:..|.|....:.:::.
Human   240 PLRDLIEKIGGWN--ITGPWDQDNFMEVLKAVAGTYR---ATPFFTVYISADSKSSNSNVIQVDQ 299

  Fly   197 APQFPMSRRHYLHPHFEGTREIYERSIENKLKLYFPEQSEHW----------RQEVASQVVQIEQ 251
            :..|..||.:||:           |:...|:...:.:..|..          .:|...||:::|.
Human   300 SGLFLPSRDYYLN-----------RTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEI 353

  Fly   252 QLAKGLPHNPALTLAQTTR--------QRTAAEMKTAYGSYVDVTRYLQLIFNDNLYMDLYETPE 308
            |||.       :|:.|..|        :.:.:|:: |....:|...:|..:.:.   ::|.::..
Human   354 QLAN-------ITVPQDQRRDEEKIYHKMSISELQ-ALAPSMDWLEFLSFLLSP---LELSDSEP 407

  Fly   309 ------DYMSNLVDVIRETPKLQLANYTMW----KALEALDIARVPASQRADI------------ 351
                  ||:..:.::|..|....|.||.:|    |...:|| .|..::|...:
Human   408 VVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLD-RRFESAQEKLLETLYGTKKSCVP 471

  Fly   352 -W--CVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQASERLLWLTLETRQK 413
             |  |:..........|.|||.:.....|.....:...|:|:..|.|   |..:|:|:..:|||.
Human   472 RWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEE---ALGQLVWMDEKTRQA 533

  Fly   414 AITKLEALK---------LHFRTHDDNKLIRQMHGLILNMDRFYPNLVSVLQWKTQRGLAKLMTE 469
            |..|.:|:.         |..:..||     ...|..::.|.|:.|::::..: :.:.:|..:.:
Human   534 AKEKADAIYDMIGFPDFILEPKELDD-----VYDGYEISEDSFFQNMLNLYNF-SAKVMADQLRK 592

  Fly   470 PVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDG 529
            |.:.|:....|     :|...||.|..|...|||.|: ...:|..|.:..:||::..::.|.||.
Human   593 PPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFY-ARNHPKALNFGGIGVVMGHELTHAFDD 656

  Fly   530 VGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYKGKPVQDKDLLRRIVADNGALDIAY 594
            .||.||..|....||.:.|.:::...|.|.:|||..: :..|:.:..:..|...:||||.|..||
Human   657 QGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQY-QVNGERLNGRQTLGENIADNGGLKAAY 720

  Fly   595 RAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDYPETVERFDE-------LPEQ 652
            .||:.||:...|      .::||.:...::|:|::|:||::|:  ..|.|...|       .|.:
Human   721 NAYKAWLRKHGE------EQQLPAVGLTNHQLFFVGFAQVWCS--VRTPESSHEGLVTDPHSPAR 777

  Fly   653 LRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            .||...||||:.|...:||.....:|....|.::
Human   778 FRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	165/694 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	164/687 (24%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	165/697 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950